Mechanisms of Disease & Translational Science

疾病机制

• 批准号: 8663555
• 负责人: HELEN L YIN
• 金额: $ 6.57万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663555
• 关键词: Disease; Translational Research

DESCRIPTION (provided by applicant): The Mechanisms of Disease and Translational Science PhD Training Track (MoD) at the UT Southwestern Graduate School will train an elite group of PhD students to become the leaders of the next generation of translational scientists. The Graduate School's Divisions of Basic Science (DBS) and Clinical Science (DCS) will collaborate to provide students with new opportunities to study human diseases at the interface between basic and clinical sciences. MoD's primary goal is to create a new breed of PhD-level scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Rationale: Translational research occurs in a bench to bedside & back continuum, and PhD students who engage in the early phase of translation (T1) must have a foundation in modern molecular approaches as well as in human physiology and pathology. They will also have to learn to navigate the team based clinical research environment and to communicate with clinicians. To accomplish these goals, we designed MoD as a supplemental track that is overlaid on the ten existing DBS PhD graduate programs. In this way, we synergize and complement existing programs, and are focused on creating a new training paradigm. MoD's unique training curriculum is designed to increase translational competencies and is not available in existing programs. In addition to developing MoD didactic courses, MoD has leveraged the rich clinical and translational education resources of DCS to offer structured experiences in patient care and clinical research and exposures to the opportunities and challenges of bridging basic and didactic courses. Trainees: We seek T32 funding to support 6 predoctoral PhD students in years 1 and 2, and 7 in subsequent years. MoD appointments are made to DBS students who are completing the first year of graduate training on a competitive basis. Duration: The duration of proposed training is for 16 months, although MoD track students continue to be associated with the program. We are only asking 12 months of T32 support for each student, in order to be able to appoint a constant number of new students each year. Anticipated Outcomes: The MoD Track provides unique opportunities and rigorous training to populate the early T1 translational research continuum, and T32 funding will allow us to further improve and expand our efforts to train PhD translational scientists. MoD students will be equipped with the "intellectual" and "practical" toolkits to spearhead the bidirectional translatio of discoveries to improve human health. The MoD plan is innovative, sustainable and cost-effective. It uniquely exploits existing institutional strengths to create a novel translational science training program that complements the research and educational mission of other programs on campus. It has been very successful and we anticipate that with new T32 funding it will have significant impact in the generation of a translational biomedical workforce.

描述（由申请人提供）： UT 西南研究生院的疾病机制和转化科学博士培训课程 (MoD) 将培养一批精英博士生，使他们成为下一代转化科学家的领导者。研究生院基础科学部（DBS）和临床科学部（DCS）将合作为学生提供在基础科学和临床科学交叉领域研究人类疾病的新机会。英国国防部的主要目标是培养新一代博士级科学家，使他们的研究项目能够满足未来未满足的治疗和诊断需求。理由：转化研究发生在从实验室到床边和背部的连续过程中，从事转化早期阶段（T1）的博士生必须具备现代分子方法以及人类生理学和病理学的基础。他们还必须学会驾驭基于团队的临床研究环境并与临床医生沟通。为了实现这些目标，我们将 MoD 设计为补充课程，覆盖现有的十个 DBS 博士研究生课程。通过这种方式，我们可以协同和补充现有计划，并专注于创建新的培训范式。国防部独特的培训课程旨在提高翻译能力，现有计划中没有提供。除了开发 MoD 教学课程外，MoD 还利用 DCS 丰富的临床和转化教育资源，提供患者护理和临床研究方面的结构化经验，并接触衔接基础课程和教学课程的机遇和挑战。受训人员：我们寻求 T32 资金来支持第 1 年和第 2 年的 6 名博士前博士生，以及随后几年的 7 名博士生。国防部任命是在竞争的基础上对完成第一年研究生培训的星展银行学生进行的。持续时间：拟议的培训持续时间为 16 个月，但国防部跟踪学生仍继续参与该计划。我们只要求为每位学生提供 12 个月的 T32 支持，以便每年能够任命恒定数量的新生。预期成果：MoD Track 提供了独特的机会和严格的培训来填充早期 T1 转化研究连续体，T32 资金将使我们能够进一步改进和扩大我们培养博士转化科学家的努力。国防部学生将配备“知识”和“实用”工具包，以带头进行发现的双向转化，以改善人类健康。国防部计划具有创新性、可持续性和成本效益。它独特地利用现有的机构优势来创建新颖的转化科学培训计划，以补充校园其他计划的研究和教育使命。它非常成功，我们预计，通过新的 T32 资金，它将对转化型生物医学劳动力的产生产生重大影响。