Johns Hopkins Pediatric Obesity Research and Training Center

约翰·霍普金斯小儿肥胖研究和培训中心

• 批准号: 8209310
• 负责人: YOUFA WANG
• 金额: $ 322.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209310
• 关键词: Johns; Hopkins; Pediatric; Obesity; Research

DESCRIPTION (provided by applicant): We propose to establish a Center of Excellence on childhood obesity research and training, based on a transdisciplinary systems science framework and methodologies. We propose to use systems modeling approaches with integrated application of spatial analysis. Modeling will be guided by behavioral models and basic science regarding food intake and body weight regulation to study the complex determinants of childhood obesity and the impacts of environmental and policy interventions. We will undertake epidemiological research to study the cascading influences of macrosocial environmental factors on individual-level behaviors and biology using existing and new data from large cohorts of children and their families in the U.S. and in China. In proposed projects we synthesize epidemiological methods and designs with basic sciences to explore how social, environmental and individual factors relate synergistically to energy balance related behaviors to differential epigenetic programming. We will also evaluate a novel multilevel food access intervention that can become a model of effective and sustainable community-based interventions and policy changes, focusing on an urban low-income population at high risk of obesity. By combining features of previous effective intervention approaches, within a broader systems framework, we hope to make desirable, food choices more accessible, sustainable, and cost effective. In addition, we will encourage and support developmental research to develop and evaluate environmental and policy interventions in the proposed Pilot Study Core. We will establish a computational workshop for systems modeling and GIS-based investigation (Research Resource Core and Training Core) that will provide an infrastructure to advance the Center's training and research mission. We will train a new cohort of investigators at different career stages in emerging system-science theories and methods. Over 40 well established investigators from leading US and international institutions bring transdisciplinary expertise to bear in highly relevant areas. The Center will build upon a solid research and training base with ongoing NIH funded projects directly related to childhood obesity and systems analysis.

描述（由申请人提供）：我们建议建立一个基于跨学科系统科学框架和方法的儿童肥胖研究和培训卓越中心。我们建议使用系统建模方法与空间分析的集成应用。建模将以行为模型和有关食物摄入和体重调节的基础科学为指导，以研究儿童肥胖的复杂决定因素以及环境和政策干预的影响。我们将利用来自美国和中国大量儿童及其家庭的现有数据和新数据，开展流行病学研究，研究宏观社会环境因素对个人行为和生物学的连锁影响。在拟议的项目中，我们将流行病学方法和设计与基础科学相结合，探索社会、环境和个人因素如何与能量平衡相关行为和差异表观遗传编程协同相关。我们还将评估一种新颖的多层次食物获取干预措施，该干预措施可以成为有效和可持续的基于社区的干预措施和政策变化的模式，重点关注肥胖高风险的城市低收入人群。通过在更广泛的系统框架内结合以前有效干预方法的特点，我们希望使理想的食物选择更容易获得、可持续且具有成本效益。此外，我们将鼓励和支持发展研究，以在拟议的试点研究核心中制定和评估环境和政策干预措施。我们将建立一个用于系统建模和基于 GIS 的调查（研究资源核心和培训核心）的计算研讨会，这将为推进该中心的培训和研究任务提供基础设施。我们将在新兴系统科学理论和方法方面培训一批处于不同职业阶段的新研究人员。来自美国和国际领先机构的 40 多名知名研究人员将跨学科专业知识应用于高度相关的领域。该中心将建立在坚实的研究和培训基础上，以及正在进行的 NIH 资助的与儿童肥胖和系统分析直接相关的项目。