Johns Hopkins University Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

约翰·霍普金斯大学站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709609
• 负责人: ALLISON L AGWU
• 金额: $ 31.32万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709609
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; Advocate; Age; Age Years; Baltimore; Black race; Caring; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communicable Diseases; Communities; Community Networks; Continuity of Patient Care; Data Collection; Development; Disease Progression; Disparity; Drug Kinetics; Ensure; Equity; Failure; Funding; Goals; Government; HIV; HIV Infections; HIV diagnosis; HIV/AIDS; Hispanic; Home; Industry; Infrastructure; Institution; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Intervention Studies; Investigational Drugs; Latinx; Lead; Maryland; Outcome; Outcomes Research; Persons; Policies; Policy Maker; Population; Prevention; Productivity; Public Health; Research; Research Activity; Research Infrastructure; Research Personnel; Risk; Science; Site; Social Behavior; State Government; Testing; Translational Research; Underrepresented Populations; United States; Universities; Vaccines; Viral; Voice; Youth; adolescent health outcomes; antiretroviral therapy; clinical care; cohort; community organizations; design; disease transmission; disorder risk; empowerment; epidemic preparedness; experience; improved; innovation; lens; marginalization; member; multidisciplinary; novel; operation; programs; protocol development; recruit; retention rate; success; synergism; virtual; young adult

ABSTRACT Johns Hopkins University Youth (ages 13-24) living with HIV comprise one fourth of new HIV diagnoses in the United States (U.S.) and have the lowest rates of engagement and retention in care and prevention, initiation of antiretroviral treatment, and virologic suppression, increasing the risk of disease progression and transmission, with important public health implications. These disparities threaten the U.S. government's target of ending new HIV infections by 2030, outlined in the Ending the Epidemic Plan for America (EHE). The Adolescent Trials' Network (ATN), the only youth-targeted HIV network, combines expertise in clinical care and research to develop optimal approaches to addressing the challenges facing youth at-risk for and living with HIV. Located in Baltimore, Maryland, an EHE jurisdiction, the Johns Hopkins Adolescent Young Adult Research Equity for Adolescent Care and HIV Consortium (JHU AYA REACH) has a long-standing overarching commitment to mitigate the impact of HIV and improve health outcomes for AYA at-risk and/or living with HIV via a clinical research program focused on integrated, cross-disciplinary studies of AYA-centered novel interventions (e.g., biomedical, management, strategy) that span from bedside to community. Synergies between clinical care research, public health, and community, centered on AYA, substantially enhances relevance, improves feasibility, optimizes success, and amplifies impact. The JHU AYA REACH infrastructure aims to optimize these synergies ultimately uniting the scientific rigor (clinical trial design and implementation, outcomes, interventions) with clinical expertise and real-world understanding, ensuring that research questions/answers are relevant, implementable, and scalable. Led by Drs. Agwu and Sanders (Co-Project Leads), the JHU AYA REACH, has a longstanding and productive involvement in clinical trials' networks and cohorts (ATN, International Maternal Pediatric Adolescent AIDS Clinical Trials' Group [IMPAACT]) with much of that involvement overseen by Westat and JHU AYA REACH is home to a prolific group of diverse, collaborative multidisciplinary investigators. The consortium includes an established network of community and governmental partners increasing the likelihood of effective translation of the research outcomes. For this application, we will: (1) Develop and conduct science that incorporates innovative approaches to addressing the critical scientific gaps and questions impacting AYAs, particularly Black and Hispanic/LatinX AYA, at-risk for or living with HIV; (2) Coordinate with diverse entities, affiliates, and stakeholders across the institution and community, including AYAs, to ensure timely, accurate, and effective engagement in the proposed research; and (3) En sure that AYA voices and lived experiences are central to the research activities of the JHU AYA REACH through active and purposeful involvement of AYA through the Youth Advisory Board (YAB) and other forums. The JHU AYA REACH's expertise, experience, and goals directly align with the ATN enriching the capacity to develop and conduct innovative and impactful interdisciplinary AYA-specific research, providing added overall value to the proposed ATN.

摘要 约翰·霍普金斯大学 在美国，感染艾滋病毒的青少年（13-24 岁）占新诊断艾滋病毒的四分之一，并且 在护理和预防、开始抗逆转录病毒治疗方面的参与度和保留率最低， 和病毒学抑制，增加疾病进展和传播的风险，重要公众 健康影响。这些差异威胁到美国政府通过以下方式结束新的艾滋病毒感染的目标 《美国结束流行病计划》(EHE) 中概述了 2030 年。青少年试验网络 (ATN) 唯一针对青少年的艾滋病毒网络，结合临床护理和研究方面的专业知识，开发最佳的 解决面临艾滋病毒风险和感染艾滋病毒的青年所面临的挑战的方法。位于巴尔的摩， 马里兰州，EHE 辖区，约翰霍普金斯大学青少年青少年研究公平计划 护理和艾滋病毒联盟 (JHU AYA REACH) 长期致力于减轻艾滋病毒感染 通过临床研究了解艾滋病毒的影响并改善高危 AYA 和/或艾滋病毒感染者的健康结果 该计划侧重于以 AYA 为中心的新颖干预措施的综合、跨学科研究（例如， 生物医学、管理、战略），从临床到社区。临床护理之间的协同作用 以 AYA 为中心的研究、公共卫生和社区，大大增强了相关性，改善了 可行性、优化成功并扩大影响。 JHU AYA REACH 基础设施旨在优化 这些协同作用最终将科学严谨性结合在一起（临床试验设计和实施、结果、 干预措施）具有临床专业知识和现实世界的理解，确保研究问题/答案 具有相关性、可实施性和可扩展性。由博士领导。 Agwu 和 Sanders（联合项目负责人），JHU AYA REACH 长期有效地参与临床试验网络和队列（ATN、 国际孕产妇儿科青少年艾滋病临床试验组 [IMPAACT]） 由 Westat 和 JHU AYA REACH 监督的参与是一个多产的多元化、协作性团队的家园 多学科调查员。该联盟包括一个已建立的社区网络和 政府合作伙伴增加了研究成果有效转化的可能性。为了这 应用程序，我们将：（1）开发和开展科学，结合创新方法来解决 影响 AYA（特别是黑人和西班牙裔/拉丁裔 AYA）的关键科学差距和问题面临风险 感染艾滋病毒或感染艾滋病毒； (2) 与机构内的不同实体、附属机构和利益相关者进行协调 包括 AYA 在内的社区，以确保及时、准确和有效地参与拟议的研究； (3) 恩 确保 AYA 的声音和生活经历是 JHU AYA 研究活动的核心 REACH 通过 AYA 通过青年咨询委员会 (YAB) 和其他组织积极、有目的地参与 论坛。 JHU AYA REACH 的专业知识、经验和目标与 ATN 直接一致，丰富了 开发和开展创新且有影响力的跨学科 AYA 特定研究的能力，提供 为拟议的 ATN 增加了整体价值。