Novel Web-based Tools for Collaborative Community-Driven Genome Feature Annotatio

用于协作社区驱动的基因组特征注释的基于网络的新型工具

• 批准号: 8464732
• 负责人: Suzanna E Lewis
• 金额: $ 60.43万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464732
• 关键词: Biological; Client; Communities; Computer software; DNA Sequence; Data; Data Set; Databases; Documentation; Elements; Enhancers; Generic Drugs; Genes; Genome; Genomics; Human Genome; Internet; Location; Mediation; Online Systems; Ontology; Organism; Process; Protocols documentation; Research Infrastructure; Research Personnel; Site; System; Technology; Work; base; data exchange; experience; flexibility; genome annotation; genome sequencing; graphical user interface; improved; novel; outreach; promoter; tool; web page

This project's overarching aim is to develop a flexible and extensible infrastructure that will allow the entire community of a given organism to easily contribute to the genome annotation process. We are doing this by integrating and significantly enhancing the functionality existing GMOD tools: Apollo, used for the creation of genomic feature annotations tied to specific locations on the DNA sequence; the Distributed Annotation System (DAS) protocol and associated software, which supports the exchange of annotations over the Internet between researchers; and Generic Genome Browser (GBrowse), used for displaying genome annotations on interactive Web pages. We are combining these applications and building on them to create a novel web-based infrastructure that will offer robust, easy-to-use tools for collaborative, community- driven genome feature annotation by a much broader community of users.

该项目的总体目的是开发灵活和 可扩展的基础设施，将允许整个社区 给定有机体容易促进基因组注释 过程。我们正在通过整合并大量进行此操作 增强现有GMOD工具的功能：Apollo，用于 与特定相关的基因组特征注释的创建 DNA序列上的位置；分布式注释系统 （DAS）协议和相关软件，该软件支持交换 研究人员之间通过互联网上的注释；和通用 基因组浏览器（GBROWSE），用于显示基因组注释 交互式网页。我们正在结合这些应用程序， 建立在它们的基础上创建一种新型的基于网络的基础架构 将为协作，社区提供强大，易于使用的工具 - 驱动的基因组特征注释是一个更广泛的社区 用户。