Developmental Research Program

发展研究计划

• 批准号: 8764765
• 负责人: Carlos L Arteaga
• 金额: $ 6.58万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8764765
• 关键词: Applications Grants; Back; Basic Science; Biology; Breast; Budgets; Clinical; Collaborations; Data; Development; Emerging Technologies; Extramural Activities; Faculty; Foundations; Funding; Gender; Grant; Investigation; Investments; Laboratories; Leadership; Mammary gland; Manuscripts; Medical center; Metric; Peer Review; Pilot Projects; Process; Program Research Project Grants; Publications; Published Comment; Publishing Peer Reviews; Research; Research Personnel; Research Project Grants; Role; Selection Criteria; Solid; TNFRSF5 gene; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Translational Research; United States National Institutes of Health; Writing; base; clinical application; high risk; innovation; malignant breast neoplasm; member; migration; programs

In an effort to promote excellent translational research in breast cancer, the Developmental Research Program (DRP) is a major focus of this Breast SPORE. The support of pilot projects allows eariy, high-risk research to move solid basic science findings toward clinical application as well as migrating provocative clinical observations back to the laboratory to understand their mechanistic basis. Main criteria for selection and funding of developmental (pilot) projects include scientific merit, relevance to mammary biology and/or breast cancer, collaboration, and potential for extramural peer-reviewed funding. There is also an emphasis on utilization of emerging technologies and on young investigators. During the current cycle and with generous institutional funds to supplement the SPORE budget, we have allocated $200,000 per year to support 21 pilot projects. This investment has resulted in at least seven R01, ROI equivalent, or K type grants for a combined budget well in excess of the investment made in the Program. In addition, data generated by three DRPs have been highly supportive of at least three multi-investigator, P50-type, or consortia type grants The DRP has also produced at least 17 peer-reviewed published manuscripts. Four investigators funded by the DRP during the last cycle are now Project co-PIs and or Core Directors in this competing renewal application. The DRP is co-led by Carios L. Arteaga, Jennifer Pietenpol, and Scott Hiebert, all with leadership roles at VICC. Applications for pilot projects are open to all Vanderbilt and Meharry Medical Center faculty members in order to maximize the number and breadth of research applications. Fifty-four applications were submitted and reviewed during the last 5 years of which 21 were funded, representing a funding rate of 39%. Special efforts are made to encourage gender and ethnic diversity among the applicants. Applications are reviewed through a multi-step process. After receiving the applications in July, Drs. Arteaga, Pietenpol and Hiebert jointly select 2- 3 expert reviewers per project. At least one of these is a reviewer from outside Vanderbilt.

为了促进乳腺癌领域优秀的转化研究，发展研究计划 (DRP) 是乳房孢子的主要焦点。试点项目的支持使得早期的、高风险的研究能够 将扎实的基础科学发现推向临床应用以及迁移具有挑战性的临床 将观察结果带回实验室以了解其机制基础。主要选择标准和 开发（试点）项目的资助包括科学价值、与乳腺生物学和/或乳腺的相关性 癌症、合作以及校外同行评审资金的潜力。还有一个重点是 利用新兴技术和年轻研究者。在当前周期内并慷慨地 为了补充 SPORE 预算，我们每年拨款 20 万美元来支持 21 个试点 项目。这项投资已导致至少七项 R01、ROI 同等或 K 类补助金 预算远远超过该计划的投资。此外，三个 DRP 生成的数据具有 大力支持至少三项多研究者、P50 类型或财团类型的资助 DRP 还 发表了至少 17 篇经过同行评审的已发表手稿。调查期间由 DRP 资助的四名调查员 上一个周期现在是此竞争更新申请中的项目联合 PI 和/或核心董事。 DRP 由 Carios L. Arteaga、Jennifer Pietenpol 和 Scott Hiebert 共同领导，他们都在 维国际商会。试点项目的申请向范德比尔特和梅哈里医学中心的所有教职人员开放 以最大限度地增加研究应用的数量和广度。已提交 54 份申请， 过去 5 年进行了审查，其中 21 项获得资助，资助率为 39%。特别努力 旨在鼓励申请人的性别和种族多样性。申请通过 多步骤过程。七月收到申请后，博士。 Arteaga、Pietenpol 和 Hiebert 共同选择 2- 每个项目 3 名专家评审员。其中至少有一位是来自范德比尔特大学以外的审稿人。