Short-term outcomes of interventions for reproductive dysfunction

生殖功能障碍干预措施的短期结果

• 批准号: 8574421
• 负责人: Larry L. Mullins
• 金额: $ 26.21万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-05 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8574421
• 关键词: Advocacy; Advocate; Age; Anxiety; Area; Benefits and Risks; Child; Child Development; Childhood; Clinical; Communities; Complication; Consensus; Cosmetics; Data; Data Collection; Decision Making; Development; Endocrinology; Etiology; Family; Family Physicians; Female; Fertility; Functional disorder; Future; Gender; Genital system; Genitalia; Goals; Incidence; Incontinence; Individual; Infection; Institution; Interdisciplinary Study; Intervention; Lead; Longitudinal Studies; Medical; Medicine; Mental Depression; Operative Surgical Procedures; Outcome; Outcome Study; Parents; Participant; Patients; Phenotype; Physicians; Procedures; Process; Prospective Studies; Psychology; Quality of life; Reaction; Regrets; Research; Research Personnel; Sex Functioning; Sexual Dysfunction; Site; Surgeon; Surgical complication; Symptoms; Techniques; Time; Translating; Uncertainty; Urethra; Urinary tract infection; Urination; Urology; base; cohort; depressive symptoms; early childhood; expectation; experience; external genitalia; male; meetings; patient registry; post-traumatic stress; prospective; psychologic; psychological outcomes; public health relevance; reproductive; sex; sex development disorder; statistics; success; urinary

DESCRIPTION (provided by applicant): Whether or not to surgically correct ambiguous genitalia to be more female- or male-typical with genitoplasty is an area of pediatric medicine that is highly controversial. Suboptimal outcomes such as poor post-surgical cosmesis and sexual dysfunction following outdated surgical procedures have driven intense controversy in the medical community over how, or if, genitoplasty should be used in the treatment of young children with ambiguous genitalia. To resolve this debate, a prospective study of outcomes of current genitoplasty procedures, including complication rates associated with these procedures, is needed of individuals who receive masculinizing or feminizing surgery during early childhood. Additionally, studies of parents who decide to proceed, or not, with genitoplasty for their young child are necessary to understand how these controversial decisions impact parents' reactions to surgical outcomes for their child. The overall goal of this proposal is to assess the outcomes of modern genitoplasty techniques with a consideration of the psychological outcome of parents who make the decisions to proceed with genital surgery for their child. This information is crucial for physicians to provide guidance to parents regarding the optimal approach for the management of ambiguous genitalia in young children, including the possibility that no surgery is best. The interdisciplinary group of clinicians and researchers included in the proposed studies spans the fields of psychology, statistics, pediatric endocrinology, and pediatric urology. The collective experience of our group optimizes our ability to translate findings from the proposed studies to a clinical setting in a timely manner.

描述（由申请人提供）：是否通过生殖器整形术来手术矫正模糊的生殖器，使其更像女性或男性典型，是儿科医学领域备受争议的一个领域。过时的手术程序带来的术后美容不佳和性功能障碍等次优结果在医学界引发了关于如何或是否应使用生殖器整形术来治疗生殖器不明确的幼儿的激烈争议。为了解决这一争论，需要对儿童早期接受男性化或女性化手术的个体进行当前生殖整形手术的结果（包括与这些手术相关的并发症发生率）的前瞻性研究。此外，有必要对决定是否对年幼的孩子进行生殖成形术的父母进行研究，以了解这些有争议的决定如何影响父母对孩子手术结果的反应。该提案的总体目标是评估现代生殖器整形技术的结果，同时考虑决定为孩子进行生殖器手术的父母的心理结果。此信息至关重要 医生可以向家长提供有关处理幼儿生殖器不明的最佳方法的指导，包括最好不进行手术的可能性。拟议研究中包括的跨学科临床医生和研究人员小组涵盖心理学、统计学、儿科内分泌学和儿科泌尿学领域。 我们团队的集体经验优化了我们及时将拟议研究的结果转化为临床环境的能力。