Long-Term Outcomes of Interventions for Reproductive Dysfunction

生殖功能障碍干预措施的长期结果

• 批准号: 10365934
• 负责人: Larry L. Mullins
• 金额: $ 53.9万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-05 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10365934
• 关键词: 5 year old; Adult; Affect; Age; Animals; Area; Behavioral; Benefits and Risks; Biological Assay; Brain; Caring; Child; Child Development; Childhood; Clinical; Cognitive; Communities; Complication; Consensus; Cosmetics; Data; Decision Making; Development; Diagnosis; Endocrinology; Etiology; Family Physicians; Fathers; Female; Feminization; Functional disorder; Future; Gender; Genital; Genitalia; Goals; Incontinence; Individual; Infant; Infection; Informed Consent; Institution; Intervention; Investigation; Longitudinal prospective study; Masculine; Measures; Medical; Medicine; Modernization; Monitor; Mothers; Natural History; Operative Surgical Procedures; Outcome; Parents; Pattern; Phenotype; Physicians; Postoperative Complications; Procedures; Psychological adjustment; Psychology; Public Health; Quality of life; Reaction; Recording of previous events; Regrets; Research Personnel; Residual state; Sex Functioning; Sexual Dysfunction; Social Development; Standardization; Surgeon; Surgical complication; Techniques; Time; Toilet Training; Translating; Uncertainty; Urethra; Urinary tract infection; Urination; Urology; ambiguous genitalia; anxiety symptoms; base; boys; care outcomes; cohort; depressive symptoms; early childhood; experience; girls; male; novel; novel marker; otoacoustic emission; patient population; post-traumatic symptoms; predictive marker; prospective; psychological outcomes; psychosocial adjustment; reproductive; reproductive function; sex; sex development disorder; social stigma; statistics; urinary

PROJECT SUMMARY/ABSTRACT Whether or not to surgically “correct” ambiguous genitalia in young children is an area of pediatric medicine that is highly controversial. Suboptimal outcomes such as poor cosmesis and sexual dysfunction following outdated surgical procedures have driven intense controversy in the medical community over how, or if, surgery should be used in the treatment of young children with ambiguous genitalia. To help resolve this debate, a prospective study of long-term outcomes of current surgical procedures, including complication rates associated with these procedures, is needed among individuals who receive masculinizing or feminizing surgery during early childhood. Additionally, studies of parents who decide to proceed, or not, with such surgeries for their young child are necessary to understand how these controversial decisions impact parents’ reactions to their child. Finally, better understanding of cognitive, behavioral, and social development in children born with ambiguous genitalia, including identification of novel markers for predicting gender development, is needed. The overall goal of this proposal is to assess the outcomes of modern surgical techniques with a consideration of the psychological outcomes of affected children and their parents. This information is crucial for physicians to provide guidance to parents regarding the optimal approach for the management of ambiguous genitalia in young children, including the possibility that no surgery is best. The interdisciplinary group of clinicians and researchers included in the proposed studies span the fields of psychology, statistics, pediatric endocrinology, and pediatric urology. The collective experience of our group optimizes our ability to translate findings from the proposed studies to a clinical setting in a timely manner.

项目摘要/摘要 在幼儿中，是否要手术“正确”模棱两可的生殖器是一种区域医学 这是高度争议的。 过时的外科手术程序引起了医学界的激烈争议，或者是否 手术被用来治疗模棱两可的生殖器。 辩论，一项对象征程序的长期结果的前瞻性研究，包括汇编率 与这些程序相关联，需要恢复或女性化的个人 童年时期的手术。 为了了解有争议的决定如何影响父母的决定，必须为幼儿进行手术 对他们的孩子的反应。 患有模棱两可的生殖器的孩子，包括对预测性别的新标记的识别 开发是需要的。 伴随着孩子及其父母的心理成果。 信息对于医师为父母提供有关他们的最佳方法的指导至关重要 幼儿的模棱两可的生殖器，包括没有手术的可能性 跨学科的临床医生和研究人员组成的跨学科研究涵盖了 心理学，统计学，小儿内分泌学和小儿泌尿科。 优化我们将发现从支撑研究转化为及时的Maner中的临床环境的能力。

项目成果

Post-operative complications following masculinizing genitoplasty in moderate to severe genital atypia: results from a multicenter, observational prospective cohort study.

• DOI: 10.1016/j.jpurol.2021.02.006
• 发表时间: 2021-06
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Long CJ;Van Batavia J;Wisniewski AB;Aston CE;Baskin L;Cheng EY;Lakshmanan Y;Meyer T;Kropp B;Palmer B;Nokoff NJ;Paradis A;VanderBrink B;Scott Reyes KJ;Yerkes E;Poppas DP;Mullins LL;Kolon TF
• 通讯作者: Kolon TF

Psychosocial Risk Profiles Among American and Dutch Families Affected by Pediatric Cancer.

• DOI: 10.1093/jpepsy/jsaa012
• 发表时间: 2020-03
• 期刊: Journal of pediatric psychology
• 影响因子: 3.6
• 作者: Christina M. Sharkey;S. Schepers;Sarah Drake;Ahna L H Pai;L. Mullins;M. Grootenhuis

Changes in levels of parental distress after their child with atypical genitalia undergoes genitoplasty.

患有非典型生殖器的孩子接受生殖器成形术后，父母的痛苦程度发生了变化。

• DOI: 10.1016/j.jpurol.2016.10.024
• 发表时间: 2017
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Wolfe-Christensen,Cortney;Wisniewski,AmyB;Mullins,AlexandriaJ;Reyes,KristyJ;Austin,Paul;Baskin,Laurence;Bernabé,Kerlly;Cheng,Earl;Fried,Allyson;Frimberger,Dominic;Galan,Denise;Gonzalez,Lynette;Greenfield,Saul;Kolon,Thomas;Kr
• 通讯作者: Kr

Post-operative complications following feminizing genitoplasty in moderate to severe genital atypia: Results from a multicenter, observational prospective cohort study.

• DOI: 10.1016/j.jpurol.2020.05.166
• 发表时间: 2020-10
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Baskin A;Wisniewski AB;Aston CE;Austin P;Chan YM;Cheng EY;Diamond DA;Fried A;Kolon T;Lakshmanan Y;Williot P;Meyer S;Meyer T;Kropp B;Nokoff N;Palmer B;Paradis A;Poppas D;VanderBrink B;Scott Reyes KJ;Tishelman A;Wolfe-Christensen C;Yerkes E;Mullins LL;Baskin L
• 通讯作者: Baskin L

Stigma, Intrusiveness, and Distress in Parents of Children with a Disorder/Difference of Sex Development.

• DOI: 10.1097/dbp.0000000000001077
• 发表时间: 2022-09-01
• 期刊: JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
• 影响因子: 2.4
• 作者: Traino, Katherine A.;Roberts, Caroline M.;Fisher, Rachel S.;Delozier, Alexandria M.;Austin, Paul F.;Baskin, Laurence S.;Chan, Yee-Ming;Cheng, Earl Y.;Diamond, David A.;Fried, Allyson J.;Kropp, Bradley;Lakshmanan, Yegappan;Meyer, Sabrina Z.;Meyer, Theresa;Buchanan, Cindy;Palmer, Blake W.;Paradis, Alethea;Reyes, Kristy J.;Tishelman, Amy;Williot, Pierre;Wolfe-Christensen, Cortney;Yerkes, Elizabeth B.;Mullins, Larry L.;Wisniewski, Amy B.
• 通讯作者: Wisniewski, Amy B.