Gender Race and Ethnic Disparities Research in Cardiovascular Disease Prevention

心血管疾病预防中的性别种族和民族差异研究

基本信息

批准号：
8507265
负责人：
LORI J MOSCA
金额：
$ 19.23万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-15 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8507265
关键词：
Academic Medical Centers Acculturation Address Adherence Admission activity Alternative Therapies Award Awareness Behavior Behavioral Blood Pressure Cardiac Cardiovascular Diseases Cardiovascular system Caregivers Caring Cause of Death Clinical Clinical Research Clinical Trials Clinical Trials Design Coronary heart disease Data Data Set Demographic Factors Disease Outcome Education Educational Background Educational Intervention Effectiveness Electronics Emergency Situation Ethnic Origin Ethnic group Etiology Exposure to Family member Female Friends Funding Future Gender Goals Health Heart Hospitalization Hospitals Income Informatics Intervention Intervention Trial Knowledge LDL Cholesterol Lipoproteins Learning Life Link Market Research Medical center Medicine Mid-Career Clinical Scientist Award (K24)Minority Minority Groups Myocardial Infarction National Heart, Lung, and Blood Institute Outcome Participant Patients Perception Population Population Heterogeneity Prevention Prevention Guidelines Prevention program Preventive Preventive Intervention Procedures Program Effectiveness Protocols documentation Psychosocial Factor Race Randomized Controlled Trials Research Research Personnel Risk Risk Factors Risk Reduction Sampling Services Social Marketing Staging Surveys Symptoms Testing Time Ursidae Family Weight Woman Work acute coronary syndrome base cardiovascular disorder prevention cardiovascular disorder risk career development caregiving design effective intervention experience follow-up health disparity heart disease risk high risk human subject improved innovation interest lifestyle factors loris medication compliance mortality multidisciplinary novel patient oriented professor programs psychosocial public health relevance racial and ethnic racial and ethnic disparities screening therapy design

项目摘要

DESCRIPTION (provided by applicant): Gender and racial/ethnic disparities in cardiovascular disease (CVD) have been well documented over the past decade of research. The applicant for renewal of a Midcareer Research Award, Dr. Lori Mosca, and many of her mentees, have contributed substantially to advancement of our knowledge in this field as a result of the initial K24 award, during which time Dr. Mosca was promoted to Professor of Medicine at Columbia University Medical Center. Substantial questions remain regarding the reasons for discrepancies in care and outcomes, a critical scientific gap that could inform interventions designed to reduce gender and racial/disparities in the prevention and treatment of CVD. The goal of this award is to provide the applicant with protected time to increase the pool of high quality multidisciplinary patient oriented researchers dedicated to a) understanding the independent contributions of gender and race/ethnicity to CVD outcomes and b) developing novel interventions targeted to modifiable factors that may reduce disparities. The award will also support the applicant's time to interact with and learn from other senior investigators with an interest in CVD disparities research, an appropriate and important commitment for her stage of career development. Extensive preliminary data by the applicant and her mentees has documented disparities in CVD awareness, risk factor control, and barriers to prevention. The proposed research provides a timely scientific opportunity to garner data from existing and ongoing studies uniquely suited to evaluate independent contributors to disparities and inform the design of future clinical trials and interventions aimed to reduce CVD disparities. The specific aims of the research include: 1) To examine the association between race/ethnic group and a) awareness of coronary heart disease as the leading cause of death in women, b) knowledge of heart attack symptoms and actions to take when experiencing heart attack symptoms, and c) perceptions of preventive/alternative therapies for coronary heart disease risk reduction, among nationally representative samples of women surveyed triennially from 1997-2009, 2) To determine whether the effectiveness of a screening and education program for family members of patients hospitalized with CVD to improve lifestyle factors over one year varies by race/ethnic group and to examine acculturation, baseline risk, and psychosocial factors as potential confounders/effect modifiers of program effectiveness and 3) To ascertain whether control of CVD risk factors is independently associated with race/ethnic group among consecutive patients admitted to the cardiovascular disease service line of a major medical center, and to determine whether the association with medication adherence and having a paid or non-paid (family member/friend) caregiver prior to hospitalization. The significance and impact of this research is that it will extend our knowledge about health disparities and will address the etiology of differential outcomes with the goal of developing effective interventions to optimize cardiovascular health among populations that bear a disproportionate burden of CVD risk.

描述（由申请人提供）：在过去的十年中，心血管疾病（CVD）的性别和种族/种族差异已得到充分证明。由于最初的K24奖，Mosca及其许多受训者洛里·莫斯卡（Lori Mosca）及其许多受训者的申请人洛里·莫斯卡（Lori Mosca）及其许多受训者为我们在该领域的知识中的发展做出了巨大贡献，在此期间，莫斯卡博士被晋升为哥伦比亚大学医学中心的医学教授。关于护理和成果差异的原因仍然存在重大问题，这是一个关键的科学差距，可以为旨在减少预防和治疗CVD的性别和种族/差异的干预措施提供依据。该奖项的目的是为申请人提供受保护的时间，以增加致力于a）了解性别和种族/民族对CVD结果的独立贡献的高质量多学科患者的研究人员，并制定针对可修改可修改因素的新型干预措施，以减少差异。该奖项还将支持申请人的时间与其他高级调查员互动和学习，对CVD差异研究感兴趣，这是她职业发展阶段的适当和重要承诺。申请人及其受训者的广泛初步数据记录了CVD意识，危险因素控制和预防障碍的差异。拟议的研究提供了及时的科学机会，以从现有和正在进行的研究中获得数据，非常适合评估差异的独立贡献者，并为未来的临床试验和旨在减少CVD差异的干预措施的设计提供了信息。 The specific aims of the research include: 1) To examine the association between race/ethnic group and a) awareness of coronary heart disease as the leading cause of death in women, b) knowledge of heart attack symptoms and actions to take when experiencing heart attack symptoms, and c) perceptions of preventive/alternative therapies for coronary heart disease risk reduction, among nationally representative samples of women surveyed triennially from 1997-2009, 2) To determine whether the effectiveness of a screening and education program for family members of patients hospitalized with CVD to improve lifestyle factors over one year varies by race/ethnic group and to examine acculturation, baseline risk, and psychosocial factors as potential confounders/effect modifiers of program effectiveness and 3) To ascertain whether control of CVD risk factors is independently associated with race/ethnic group among consecutive patients admitted to the cardiovascular disease service line of a major medical center, and to determine whether在住院之前，与药物依从性以及有薪水或非薪水（家人/朋友）护理人员的关联。这项研究的重要性和影响是，它将扩展我们对健康差异的了解，并将解决差异结果的病因，目的是制定有效的干预措施，以优化承担CVD风险负担不成比例的人群中的心血管健康。