Applied Preventive Cardiology Research

应用预防心脏病学研究

基本信息

批准号：
7619027
负责人：
LORI J MOSCA
金额：
$ 14.99万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-01 至 2010-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7619027
关键词：
Adherence Award Cardiology Cardiovascular Diseases Cardiovascular system Caring Cholesterol Clinical Clinical Research Clinical Trials Control Groups Development Disease Outcome Education Effectiveness Environment Ethnic Origin Event Family member Foundations Funding Gender Genes Goals Grant Guidelines Health Healthy People 2010 Intervention Life Style Low-Density Lipoproteins Mentors Methods Minority National Heart, Lung, and Blood Institute Outcome Patients Physicians Population Population Heterogeneity Prevention Prevention Guidelines Prevention Research Prevention strategy Preventive Research Research Infrastructure Research Personnel Resources Scientist Secondary Prevention Structure Testing Time Training United States National Institutes of Health Universities Woman base cardiovascular disorder prevention cardiovascular disorder risk career compliance behavior cost effectiveness ethnic difference high risk improved loris next generation novel patient oriented patient oriented research patient population primary outcome programs sex skills treatment as usual

项目摘要

DESCRIPTION (provided by applicant): Despite extensive research documenting the efficacy of cardiovascular disease (CVD) preventive strategies, these are not uniformly applied across diverse patient populations. The applicant for this Midcareer Investigator Award, Dr. Lori Mosca, has an outstanding record of commitment to patient-oriented research to evaluate gender and ethnic differences in CVD risk, barriers to preventive care, and novel methods to increase patient adherence to national prevention guidelines. She has held an NHLBI National Research Career Award in Preventive Cardiology and an NHLBI Mentored Clinical Scientist Development Grant. The K24 grant will support Dr. Mosca to continue a scientific trajectory directed to mentor the next generation of applied scientists in preventive cardiology and to further refine her research skills related to evaluating interventions to improve lifestyle and outcomes in diverse patients at risk for CVD events. The long-term goal of this project is to increase the number and quality of clinical scientists dedicated to research to improving the quality of CVD preventive care in diverse populations. The specific aims are to 1) Protect Dr. Mosca's time to mentor and conduct patient-oriented research in CVD prevention while advancing her skills in clinical research focused on quality CVD outcomes through formal courses, 2) Establish a structured mentoring program in patient-oriented CVD prevention research targeted to early career investigators, and 3) Support new research to test the impact of an intervention involving Dr, Mosca to increase adherence to national guidelines for CVD prevention among 370 high risk patients. A proposed clinical trial takes advantage of the infrastructure of an ongoing study to identify family members and visitors of patients hospitalized with CVD that may also be at increased risk of CVD events due to shared genes and/or lifestyle. The primary outcome of the trial is the % of high risk patients that achieve an optimal cholesterol level at 1 year compared to those receiving a control intervention. Other ongoing studies funded by the NIH and foundations will provide an enriched research environment to support the K24 goals. Columbia University is uniquely suited to train clinical scientists in issues related to minority and women's cardiovascular health as many of our studies have nearly 50% participation by these populations. The research and careers supported by this project are expected to have a positive impact on attainment of the Healthy People 2010 lifestyle and CVD prevention.

描述（由申请人提供）：尽管有广泛的研究记录了心血管疾病（CVD）预防策略的功效，但这些策略并未统一应用于多样化的患者人群中。该中期研究员奖的申请人洛里·莫斯卡（Lori Mosca）博士拥有对以患者为导向的研究的承诺记录，以评估CVD风险的性别和种族差异，预防性护理的障碍以及提高患者遵守国家预防准则的新方法。她曾获得NHLBI国家研究职业奖，并获得了NHLBI指导的临床科学家发展赠款。 K24赠款将支持Mosca博士继续进行科学轨迹，该轨迹指导下一代的预防性心脏病学科学家，并进一步完善与评估干预措施相关的研究技能，以改善生活方式和遇到CVD事件风险的多元化患者的结果。该项目的长期目标是增加致力于研究改善各种人群中CVD预防保健质量的临床科学家的数量和质量。具体目的是1）保护Mosca博士在CVD预防方面指导和进行以患者为导向的研究的时间，同时推进她在临床研究中的技能，重点是通过正式课程，以优质的CVD结局，2）），2）在患者面向患者的CVD预防研究中，为早期的研究人员提供了针对早期研究的研究，并支持促进新的研究，以增强介入的研究，以增强介绍的介绍，并支持促进新的研究，3）Mest swort inters Intervention tote native native witre Driventer in Mestenter in Mestement，MOSC的MOSC介绍MOSC的MOSC，3） 370名高风险患者的CVD预防。一项拟议的临床试验利用正在进行的研究的基础设施来识别住院CVD的患者的家庭成员和访客，由于共享基因和/或生活方式，这也可能会增加CVD事件的风险。该试验的主要结果是与接受对照干预的高风险患者百分比在1年达到最佳胆固醇水平。 NIH和基金会资助的其他正在进行的研究将提供丰富的研究环境，以支持K24目标。哥伦比亚大学非常适合培训与少数群体和妇女心血管健康有关的临床科学家的培训，因为这些人群的参与近50％。预计该项目支持的研究和职业将对获得2010年健康人的生活方式和CVD预防产生积极影响。