Multi-method Assessment of Affective and Situational Antecedents of Marijuana Use

大麻使用的情感和情境前因的多方法评估

基本信息

批准号：
8227973
负责人：
JULIA D BUCKNER
金额：
$ 15.82万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至 2014-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Marijuana is the most commonly used illicit drug in the United States and internationally and nearly one-third of current marijuana users in the U.S. suffer from a marijuana use disorder (MUD). Thus, identification of individual difference factors related to marijuana use among current users has important public health implications. One such individual difference factor is social anxiety. Social anxiety disorder (SAD), a disorder characterized by fear of scrutiny in social situations, is thought to serve as a risk and maintaining for marijuana use. The present proposal is designed to meet the objectives of the Exploratory/Developmental grants (R21) program to encourage innovative, exploratory and developmental research whose findings have promise to advance health-related research regarding the prevention and treatment of MUD. Specifically, the proposed R21 outlines a novel approach to understanding vulnerability to marijuana use by examining the physiological, cognitive, and emotional antecedents of marijuana use among individuals with and without an identified psychological vulnerability to marijuana-related problems (those with SAD) using a multi-method approach in a series of two studies. In Study 1, antecedents of marijuana craving will be examined under controlled laboratory conditions using a social anxiety manipulation paradigm. If social anxiety is a risk factor for using marijuana to manage anxious reactions, it follows that elevations in state social anxiety should elicit marijuana craving, particularly among those with SAD. We will test this hypothesis by inducing state social anxiety and examining whether increases in self-reported anxiety and physiological arousal predict increases in marijuana craving. Further, participants will provide reasons for marijuana use while experiencing anxiety- induced craving. In Study 2, ecological momentary assessment (EMA) will be used to examine the naturalistic antecedents of marijuana use and assess (1) the extent to which social anxiety-provoking situations serve as a risk factor for marijuana use and (2) the affective, situational, and cognitive antecedents of marijuana among those with and without SAD. It is believed that the use of multiple methodologies will provide convergent and complementary data regarding affective, situational, and cognitive variables related to marijuana use. For instance, examination of the relations between state social anxiety and marijuana in the laboratory will allow us to test whether physiological arousal predicts marijuana craving whereas using EMA allows for the collection of data regarding actual marijuana use in real-life situations. The proposed studies will provide important information regarding proximal factors that maintain marijuana use as well as shed light on the understudied relationship between SAD and MUD. Such data have direct, translational implications for the prevention and treatment of marijuana use and MUD. PUBLIC HEALTH RELEVANCE: Marijuana is the most commonly used illicit drug in the United States and internationally, with nearly one-third of users experiencing marijuana-related problems significant enough to warrant a diagnosis of marijuana use disorder (MUD). People with social anxiety disorder experience particular difficulty managing marijuana use. The present project uses state-of-the-art scientific methodology to study proximal factors related to marijuana use among those with and with SAD.

描述（由申请人提供）：大麻是美国和国际上最常用的非法药物，目前美国近三分之一的大麻使用者患有大麻使用障碍（MUD）。因此，识别当前使用者中与大麻使用相关的个体差异因素具有重要的公共卫生意义。其中一种个体差异因素是社交焦虑。社交焦虑症（SAD）是一种以害怕在社交场合受到审视为特征的疾病，被认为是吸食大麻的风险和维持因素。本提案旨在实现探索性/发展补助金 (R21) 计划的目标，以鼓励创新、探索性和发展性研究，其研究结果有望推进有关预防和治疗 MUD 的健康相关研究。具体来说，拟议的 R21 概述了一种了解大麻使用脆弱性的新方法，通过使用多种方法检查有或没有确定的对大麻相关问题（患有 SAD 的人）的心理脆弱性的个体使用大麻的生理、认知和情感前因。 -一系列两项研究中的方法。在研究 1 中，将使用社交焦虑操纵范式在受控实验室条件下检查大麻渴望的前因。如果社交焦虑是使用大麻来控制焦虑反应的一个危险因素，那么社交焦虑状态的升高就会引发对大麻的渴望，特别是对于患有季节性情感障碍的人来说。我们将通过诱导状态社交焦虑并检查自我报告的焦虑和生理唤醒的增加是否预示着大麻渴望的增加来检验这一假设。此外，参与者将提供在经历焦虑引起的渴望时使用大麻的原因。在研究 2 中，生态瞬时评估 (EMA) 将用于检查吸食大麻的自然前因，并评估 (1) 引发社交焦虑的情况在多大程度上成为吸食大麻的风险因素，以及 (2) 情感、患有和不患有季节性情绪失调的人吸食大麻的情境和认知前因。据信，多种方法的使用将提供与大麻使用相关的情感、情境和认知变量的收敛和补充数据。例如，在实验室中检查状态社交焦虑与大麻之间的关系将使我们能够测试生理唤醒是否可以预测对大麻的渴望，而使用 EMA 可以收集有关现实生活中实际使用大麻的数据。拟议的研究将提供有关维持大麻使用的近端因素的重要信息，并阐明 SAD 和 MUD 之间尚未得到充分研究的关系。这些数据对于大麻使用和 MUD 的预防和治疗具有直接的转化意义。公共健康相关性：大麻是美国和国际上最常用的非法药物，近三分之一的使用者遇到与大麻相关的问题，其严重程度足以诊断为大麻使用障碍 (MUD)。患有社交焦虑症的人在管理大麻使用方面遇到特别困难。本项目采用最先进的科学方法来研究患有季节性情感障碍的人与大麻使用相关的近端因素。