Biostatistics, Epidemiology, and Bioinformatics Core (BEBiC)

生物统计学、流行病学和生物信息学核心 (BEBiC)

基本信息

批准号：
8754434
负责人：
Michelle Ann Barton
金额：
$ 15.89万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-25 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8754434
关键词：
Algorithms Basic Science Bioinformatics Biometry Clinical Research Clinical Trials Collaborations Collection Communication Confidentiality of Patient Information Consultations Data Data Analyses Data Collection Data Quality Data Security Educational workshop Ensure Epidemiologic Studies Epidemiology Experimental Designs Future Genomics Grant Human Resources Laboratories Manuscripts Mentors Methodology Modeling Pilot Projects Process Publications Publishing Quality Control Reporting Research Research Design Research Personnel Resources Sample Size Single Nucleotide Polymorphism Staging Statistical Data Interpretation Statistical Methods Suggestion Survival Analysis System Testing Translational Research University of Texas M D Anderson Cancer Center Writing anticancer research data acquisition data integration data management design innovation investigator training meetings outreach program pre-clinical programs prospective research study sound statistics

项目摘要

The Biostatistics, Epidemiology and Bioinformatics Gore (BEBiC) will provide professional expertise in biostatistics, epidemiology and bioinformatics for all research studies within the Partnership. The Gore will be a comprehensive, multilateral resource for data acquisition and management, design of laboratory experiments, epidemiological studies and clinical trials, statistical analysis, and publishing translational research generated by the Partnership. The BEBiC will incorporate sound experimental design principles within all projects and programs; carry out data analyses using appropriate statistical methodology; and contribute to interpretation of results through written reports and frequent interaction with project and program co-leaders. The Core will provide an integrated data management system to facilitate communication among all projects and cores, which will be customized to meet the needs ofthe Partnership. This process includes prospective data collection, data quality control, data security, and patient confidentiality. Thus, from inception to reporting, projects and programs will benefit from collaboration with the BEBiC. In addition, the BEBIC will organize different workshops related with the statistical and bioinformatics needs for every research study, particularly with all types of regression modeling and variable selection, survival analysis and optimization of dynamic treatment regimes, clinical trials, sample size, power calculations and statistics and algorithms for bioinformatics. Also, the BEBiC's personnel will develop new statistical methodologies in cancer research according to the projects needs.

戈尔生物统计学、流行病学和生物信息学 (BEBiC) 将为合作伙伴关系内的所有研究提供生物统计学、流行病学和生物信息学方面的专业知识。戈尔将成为一个全面的多边资源，用于数据采集和管理、实验室实验设计、流行病学研究和临床试验、统计分析以及出版合作伙伴产生的转化研究。 BEBiC 将在所有项目和计划中纳入合理的实验设计原则；使用适当的统计方法进行数据分析；通过书面报告以及与项目和项目群共同领导者的频繁互动，为结果的解释做出贡献。该核心将提供一个集成的数据管理系统，以促进所有项目和核心之间的通信，该系统将根据合作伙伴的需求进行定制。该过程包括前瞻性数据收集、数据质量控制、数据安全和患者保密。因此，从启动到报告，项目和计划都将从与 BEBiC 的合作中受益。此外，BEBIC还将组织与每项研究的统计和生物信息学需求相关的不同研讨会，特别是所有类型的回归模型和变量选择、生存分析和动态治疗方案的优化、临床试验、样本量、功效计算和生物信息学的统计和算法。此外，BEBiC 的人员将根据项目需要开发新的癌症研究统计方法。