Penn TREC Survivor Center

宾夕法尼亚 TREC 幸存者中心

• 批准号: 8377466
• 负责人: Kathryn H. Schmitz
• 金额: $ 18.25万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8377466
• 关键词: Address; Adopted; Adverse effects; Adverse event; Animals; Attenuated; Back; Basic Science; Biological Markers; Biometry; Body Weight decreased; Cancer Biology; Cancer Survivor; Cancer Survivorship; Categories; Clinical; Clinical Oncology; Clinical Trials; Cost Effectiveness Analysis; Costs and Cost Analysis; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Economic Policy; Education; Education and Outreach; Ensure; Epidemiology; Equilibrium; Exercise; Exercise Physiology; Face; Fostering; Funding; Generations; Glues; Goals; Growth; Health; Health Personnel; Health Policy; Human; Individual; Institution; Intervention; Knowledge; Left; Length; Life; Link; Lymphedema; Malignant Neoplasms; Methodology; Mission; Modeling; Molecular and Cellular Biology; Motivation; Mus; Nature; Obesity; Outcome; Pathway interactions; Physical Function; Physical Medicine; Physicians; Policies; Population; Public Health; Quality of life; Recurrence; Recurrent Malignant Neoplasm; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Risk; Science; Scientist; Side; Survivors; T-Cell Receptor-Rearrangement Excision DNA Circles; Testing; The Sun; Time; Training; Training Activity; Training and Education; Translating; Translational Research; Ursidae Family; Vision; Weight maintenance regimen; Work; cancer recurrence; cancer site; cancer therapy; clinical application; clinical care; cost; cost effective; cost effectiveness; dissemination research; energy balance; health economics; improved; interest; intervention effect; malignant breast neoplasm; model development; mouse model; obesity treatment; organizational structure; outreach; outreach program; prevent; programs; sedentary; weight loss intervention

The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature ofthe center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.

宾夕法尼亚州 TREC 幸存者中心的总体目标是通过建立从“实验室到战壕”的可持续跨学科研究、教育和推广计划来延长癌症生存时间并提高癌症生存质量。拟议的中心将增强对从动物到人类模型的能量平衡与乳腺癌复发之间因果关系的了解，并探索这些知识并将其与政策层面的广泛人口影响相结合，以控制与肥胖相关的疾病 癌症幸存者中的不良事件。提出了三个项目。项目 1 将探索运动和/或减肥是否会改变小鼠乳腺癌复发，并探索对假设解释这些影响的机械途径生物标志物的影响。项目 2 将项目 1 的生物标志物发现转化为人体模型。还将评估对临床淋巴水肿结果的干预效果 项目 2。项目 3 将评估运动和/或减肥对于患有淋巴水肿的乳腺癌幸存者是否具有成本效益。在组织上，行政核心将充当研究人员之间的粘合剂，以便随着项目、培训活动和发展试点的展开，该中心的跨学科、转化性质得到保留和扩展。该开发核心将结合我们机构在肥胖和癌症生物学方面的独特优势，并将 TREC 计划扎实地扩展到癌症生存领域，从而加快研究能量学对癌症复发影响的能力。教育/培训和外展核心将为科学家和临床医生提供能量平衡和癌症生存方面的培训，其双重目的是教育医疗保健提供者了解幸存者独特的能量平衡问题，并激发人们对这一不断增长的人口进行从基础到基础的研究兴趣。科学到临床应用。宾夕法尼亚州 TREC 幸存者中心将利用宾夕法尼亚州科学研究人员和医师科学家的巨大优势，加快能量学、癌症复发和持续不良治疗影响的研究能力，并传播这些研究结果，以改善癌症幸存者的临床护理和结果。