Penn TREC Survivor Center

宾夕法尼亚 TREC 幸存者中心

• 批准号: 8072520
• 负责人: Kathryn H. Schmitz
• 金额: $ 19.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072520
• 关键词: Address; Adopted; Adverse effects; Adverse event; Animals; Attenuated; Back; Basic Science; Biological Markers; Biometry; Body Weight decreased; Cancer Biology; Cancer Survivor; Cancer Survivorship; Categories; Clinical; Clinical Oncology; Clinical Trials; Cost Effectiveness Analysis; Costs and Cost Analysis; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Economic Policy; Education; Education and Outreach; Ensure; Epidemiology; Equilibrium; Exercise; Exercise Physiology; Face; Fostering; Funding; Generations; Glues; Goals; Growth; Health; Health Personnel; Health Policy; Human; Individual; Institution; Intervention; Knowledge; Left; Length; Life; Link; Lymphedema; Malignant Neoplasms; Methodology; Mission; Modeling; Molecular and Cellular Biology; Motivation; Mus; Nature; Obesity; Outcome; Pathway interactions; Physical Function; Physical Medicine; Physicians; Policies; Population; Public Health; Quality of life; Recurrence; Recurrent Malignant Neoplasm; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Risk; Science; Scientist; Side; Survivors; T-Cell Receptor-Rearrangement Excision DNA Circles; Testing; The Sun; Time; Training; Training Activity; Training and Education; Translating; Translational Research; Ursidae Family; Vision; Weight maintenance regimen; Work; cancer recurrence; cancer site; cancer therapy; clinical application; clinical care; cost; cost effective; cost effectiveness; dissemination research; energy balance; health economics; improved; interest; intervention effect; malignant breast neoplasm; model development; mouse model; obesity treatment; organizational structure; outreach; outreach program; prevent; programs; sedentary; weight loss intervention

The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature ofthe center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.

Penn TREC幸存者中心的总体目标是通过建立可持续的跨学科研究，教育和外展计划来改善癌症幸存的长度和质量，该计划从“板凳到沟渠”延伸。拟议的中心将增强对能量平衡与乳腺癌复发的因果关系的了解，从动物到人类模型，并探索和整合到与肥胖相关的政策水平上的广泛人口影响的知识。 癌症幸存者的不利事件。提出了三个项目。项目1将探讨运动和/或体重减轻是否会改变小鼠的乳腺癌复发，并探索对假设解释这些作用的机械途径生物标志物的影响。项目2将将项目1生物标志物的发现转化为人类模型。干预对临床淋巴水肿预后的影响也将在 项目2。项目3将评估运动和/或体重减轻对于患有淋巴水肿的乳腺癌幸存者是否具有成本效益。在组织上，行政核心将充当调查人员之间的胶水，以便随着项目，培训活动和发展飞行员的展开，跨学科的，转化性的性质得到了保留和扩展。发育核心将通过结合我们机构在肥胖和癌症生物学方面的独特优势，并将TREC倡议牢固地扩展到癌症生存方面，从而加速研究能量对癌症复发的影响。教育/培训和外展核心将培训科学家和临床医生有关能量平衡和癌症幸存的培训，其双重目的是教育医疗保健提供者关于幸存者中独特的能源平衡问题的教育，并激发了对基本人群不断增长的研究的研究的兴趣。临床应用科学。 Penn TREC幸存者中心将利用宾夕法尼亚州科学研究人员和医师科学家的相当大优势，以加速研究能量，癌症复发和持续性不良治疗效果的能力，并分散这些发现以改善癌症幸存者的临床护理和结果。