The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

使用新技术研究糖尿病患者的骨骼健康

• 批准号: 8290321
• 负责人: Laura Anne Graeff Armas
• 金额: $ 13.06万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290321
• 关键词: Affect; Age; Alkaline Phosphatase; American; Anabolic Agents; Antibodies; Biochemical; Biometry; Biopsy; Biopsy Specimen; Blood Glucose; Bone Density; Bone Diseases; Bone Mineral Contents; Bone Resorption; Bone remodeling; Calcium; Cardiovascular system; Case-Control Studies; Celiac Disease; Clinical; Clinical Endocrinology; Clinical Research; Creatinine; Cyclophosphamide; Data; Diabetes Mellitus; Diabetic mouse; Dietary Factors; Disease; Dual-Energy X-Ray Absorptiometry; Electrolytes; Endocrinology; Enrollment; Enzymes; Epidemiology; Estradiol; Family; Fellowship; Female; Fluorochrome; Fracture; Frequencies; General Population; Glucose; Glycosylated Hemoglobin; Goals; Health; Hip region structure; Human; Instruction; Insulin-Dependent Diabetes Mellitus; Insulin-Like Growth Factor I; Internal Medicine; K-Series Research Career Programs; Kidney; Knowledge; Label; Laboratories; Lead; Life Expectancy; Liver; Master of Public Health; Measures; Mentors; Metabolism; Methods; Modeling; Nervous system structure; Osteocalcin; Osteogenesis; Osteoporosis; Outcome; Patients; Peripheral; Phosphorus; Physicians; Population; Prevalence; Prevention; Procedures; Publishing; Rattus; Recording of previous events; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Risk; Scientist; Serum; Structure; Techniques; Testosterone; Tetracyclines; Thyroid Function Tests; Time; Training; Translational Research; Trauma; Treatment Factor; United States; Universities; Urea Nitrogen; Vertebral column; Work; X-Ray Computed Tomography; bone; bone health; bone mass; bone strength; bone turnover; career; density; design; diabetes control; diabetic; diabetic patient; experience; human study; lifestyle factors; male; new technology; programs; prospective; repaired; sex; skeletal; skills; type I diabetic; urinary

Dr, Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long- term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density. RELEVANCE (See Instructions): Diabetics have higher rates of fracture than the general population. The mechanism is uncertain. Studies of human bone mass and rat. models of diabetes point to reduced bone turnover that leads to fragility and fractures. This has not been shown in humans. This will be the first study in humans of diabetic bone disease using histomorphometry, micro-CT and pQCT to elucidate the mechanisms of bone fragility. This will lead to further research in prevention and treatment of bone disease in patients with diabetes.

阿玛斯博士花费了大量时间来发展她的研究和职业生涯，完成了 临床内分泌学研究员，成为美国内科医学委员会内分泌学认证， 糖尿病和新陈代谢，以及完成、展示和出版临床研究项目。她的长—— 学期目标是成为一名学术医师科学家，在以下领域进行临床转化研究 骨疾病并成为最先进的骨分析方法的专家。该指导 K 奖包括 a 公共卫生硕士，专注于生物统计学和流行病学。它还专注于 骨研究领域所需的技术技能，包括经髂骨活检程序的培训， 组织形态计量学、微型计算机断层扫描 (micro-CT) 和外周定量计算机断层扫描 断层扫描（pQCT）。 克赖顿大学骨质疏松症研究中心是研究骨骼的独特场所，拥有超过 45 年的研究经验 临床研究经验。 Robert R. Recker 博士在骨骼研究的进一步发展中发挥了重要作用 场地。建立研究学术生涯所需的技能和知识正在被使用 研究中心及其附属机构的数十名人员每天都在进行研究。 该指导研究项目旨在利用统计设计的技术技能和知识 并研究并将其应用于糖尿病患者的骨病问题。这是一个有前景的、 使用 DXA、骨标志物、pQCT、组织形态计量学和显微 CT 进行糖尿病受试者的病例对照研究 经髂骨活检。这项人体研究旨在阐明 1 型糖尿病对 1) 的影响 骨重塑，包括骨形成和吸收的组织形态学和生化测量， 2）结构，包括小梁的微结构排列和骨矿物质密度。 相关性（参见说明）： 糖尿病患者的骨折率高于一般人群。其机制尚不确定。研究 人类骨量和大鼠。糖尿病模型表明骨转换减少导致脆弱和 骨折。这尚未在人类身上得到证实。这将是第一个针对人类糖尿病骨病的研究 使用组织形态计量学、显微 CT 和 pQCT 来阐明骨脆性的机制。这将导致 进一步研究糖尿病患者骨病的防治。