The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

使用新技术研究糖尿病患者的骨骼健康

• 批准号: 8102875
• 负责人: Laura Anne Graeff Armas
• 金额: $ 13.06万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8102875
• 关键词: Affect; Age; Alkaline Phosphatase; American; Anabolic Agents; Antibodies; Biochemical; Biometry; Biopsy; Biopsy Specimen; Blood Glucose; Bone Density; Bone Diseases; Bone Mineral Contents; Bone Resorption; Bone remodeling; Calcium; Cardiovascular system; Case-Control Studies; Celiac Disease; Clinical; Clinical Endocrinology; Clinical Research; Creatinine; Cyclophosphamide; Data; Diabetes Mellitus; Diabetic mouse; Dietary Factors; Disease; Dual-Energy X-Ray Absorptiometry; Electrolytes; Endocrinology; Enrollment; Enzymes; Epidemiology; Estradiol; Family; Fellowship; Female; Fluorochrome; Fracture; Frequencies; Glucose; Glycosylated Hemoglobin; Goals; Health; Hip region structure; Human; Insulin-Dependent Diabetes Mellitus; Insulin-Like Growth Factor I; Internal Medicine; K-Series Research Career Programs; Kidney; Knowledge; Label; Laboratories; Lead; Life Expectancy; Liver; Master of Public Health; Measures; Mentors; Metabolism; Methods; Nervous system structure; Osteocalcin; Osteogenesis; Osteoporosis; Outcome; Patients; Peripheral; Phosphorus; Physicians; Population; Prevalence; Prevention; Procedures; Publishing; Recording of previous events; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Risk; Scientist; Serum; Structure; Techniques; Testosterone; Tetracyclines; Thyroid Function Tests; Time; Training; Translational Research; Trauma; Treatment Factor; United States; Universities; Urea Nitrogen; Vertebral column; Work; X-Ray Computed Tomography; bone; bone health; bone mass; bone strength; bone turnover; career; density; design; diabetes control; diabetic; diabetic patient; experience; human study; lifestyle factors; male; new technology; programs; prospective; repaired; sex; skeletal; skills; type I diabetic; urinary

DESCRIPTION (provided by applicant): Dr. Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long-term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density.

描述（由申请人提供）：Armas博士通过完成临床内分泌奖学金，成为美国内科委员会，在内分泌，糖尿病和代谢方面认证，并完成，介绍和出版临床研究项目，已经花费了大量时间来发展自己的研究和职业生涯。 。她的长期目标是成为一名学术医师科学家，在骨骼疾病领域进行临床转化研究，并成为最先进的骨骼分析方法的专家。这项指导的K奖包括公共卫生硕士，专注于生物统计学和流行病学。它还集中在骨研究领域所需的技术技能上，包括跨性骨活检程序，组织形态计量学，微型计算机扫描（Micro-CT）和外围定量计算机断层扫描（PQCT）的训练。 Creighton University骨质疏松研究中心是研究骨骼超过45年的临床研究经验的独特场所。罗伯特·R·莱克（Robert R. Recker）博士一直在进一步研究骨骼领域的研究。每天都有数十个人使用研究中心，每天都使用研究研究职业所需的技能和知识。该指导的研究项目旨在利用统计设计和研究的技术技能和知识，并将其应用于糖尿病患者的骨骼疾病问题。这是一项使用DXA，骨标记，PQCT，Histormorphoteming和Micro-CT的糖尿病患者进行的前瞻性病例对照研究。这项人类研究旨在阐明1型糖尿病对1）骨骼重塑的影响，包括骨形成和吸收的组织形态计量和生化测量，以及2）对结构，包括小径和骨矿物质密度的微构造布置。