Optical Imaging of the Pulmonary Airways in the Assessment of Lung Cancer

肺气道光学成像在肺癌评估中的应用

• 批准号: 8311819
• 负责人: Melissa J Suter
• 金额: $ 24.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-02 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311819
• 关键词: Accounting; Attention; Award; Biological; Biopsy; Bronchoscopes; Bronchoscopy; Cancer Etiology; Carcinoma in Situ; Catheters; Cessation of life; Classification; Clinic; Clinical; Clinical Research; Clinical Trials; Conduct Clinical Trials; Custom; Detection; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Dysplasia; Early Diagnosis; Environment; Ethics; Evaluation; Family suidae; Feasibility Studies; Fostering; Foundations; Frequencies; Future; General Hospitals; Goals; High Prevalence; Histopathology; Image; Image Guided Biopsy; Imaging Techniques; Imaging technology; Instruction; International; Lasers; Lead; Lesion; Lobectomy; Lung; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Massachusetts; Medical Imaging; Melissa; Mentors; Mentorship; Methods; Microinvasive; Microscopic; Mucous Membrane; Natural History; Operative Surgical Procedures; Optics; Pathology; Pathway interactions; Patient Schedules; Patients; Phase; Pilot Projects; Procedures; Process; Pulmonary Pathology; Pulmonology; Research; Research Personnel; Research Project Grants; Research Training; Resected; Resolution; Safety; Screening procedure; Sensitivity and Specificity; Specimen; Squamous cell carcinoma; Survival Rate; System; Techniques; Testing; Tissues; Training; Validation; Work; authority; base; career; design; design and construction; experience; imaging probe; in vivo; lung imaging; medical schools; mortality; optical imaging; outcome forecast; safety study; safety testing; success; tool

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer related death. Arising in the bronchial mucosa, squamous cell carcinoma (SCC) is currently difficult to detect early in the disease process. For this reason it is typically well advanced upon discovery providing patients little hope of cure. The research focus of this proposal is to develop and test an accurate screening and assessment tool for the detection and diagnosis of squamous cell carcinoma, and its precursor lesions, in the pulmonary airways. It is hoped that through early detection, diagnosis and consequent treatment the mortality rate associated with the disease can be greatly reduced. This research project is based on a newly developed optical imaging technique termed optical frequency domain imaging (OFDI). OFDI is a noninvasive imaging technology that provides cross-sectional images of biological tissues in resolutions comparable with histopathology. We hypothesize that OFDI will be capable of comprehensively imaging the pulmonary airways at microscopic resolutions and, based on the acquired images, we will be able to accurately differentiate and diagnose SCC and its precursor lesions. During the mentored phase of this award, OFDI diagnostic criteria for the evaluation of bronchial pathology will be established, and a custom OFDI imaging probe will be developed and tested. In the independent phase of the award, an OFDI guided-biopsy paradigm with laser marking will be developed and tested, and a subsequent clinical trial to demonstrate the feasibility of the guided-biopsy paradigm will be conducted. Research training will be a core component of this award proposal during the mentored phase with the primary purpose of providing the candidate with a strong foundation in pulmonary medicine and pathology to supplement her existing expertise in medical imaging and biomedical optics. Training will take place at the Wellman Center for Photomedicine, Massachusetts General Hospital under the mentorship of Drs Guillermo Tearney and Brett Bouma, both considered international authorities in optical diagnostics, and at the Lahey Clinic under the direction of Dr. John Beams, an international leader in interventional pulmonary medicine. This training will be further supplemented with formal coursework at Harvard Medical School, and Massachusetts General Hospital. The training and research contributions supported by this K99/ROO award will serve to establish Dr. Melissa Suter as a successful independent investigator.

描述（由申请人提供）：肺癌是癌症相关死亡的主要原因。鳞状细胞癌（SCC）起源于支气管粘膜，目前很难在疾病过程的早期发现。出于这个原因，它通常在发现时就已经很先进了，给患者带来治愈的希望很小。该提案的研究重点是开发和测试一种准确的筛查和评估工具，用于检测和诊断肺气道中的鳞状细胞癌及其癌前病变。希望通过早期发现、诊断和随后的治疗，可以大大降低与该疾病相关的死亡率。该研究项目基于一种新开发的光学成像技术，称为光频域成像（OFDI）。 OFDI 是一种非侵入性成像技术，可提供生物组织的横截面图像，其分辨率可与组织病理学相媲美。我们假设 OFDI 将能够以显微分辨率对肺气道进行全面成像，并且根据获取的图像，我们将能够准确区分和诊断 SCC 及其前驱病变。在该奖项的指导阶段，将建立用于评估支气管病理学的 OFDI 诊断标准，并将开发和测试定制的 OFDI 成像探针。在该奖项的独立阶段，将开发和测试具有激光标记的 OFDI 引导活检范例，并将进行后续临床试验以证明引导活检范例的可行性。研究培训将是该奖项提案在指导阶段的核心组成部分，其主要目的是为候选人提供肺医学和病理学方面的坚实基础，以补充她在医学成像和生物医学光学方面现有的专业知识。培训将在马萨诸塞州总医院 Wellman 光医学中心进行，由 Guillermo Tearney 和 Brett Bouma 博士（两位被认为是光学诊断领域的国际权威）指导，并在 Lahey 诊所进行，由国际领袖 John Beams 博士指导在介入肺医学领域。该培训将得到哈佛医学院和马萨诸塞州总医院的正式课程的进一步补充。 K99/ROO 奖项支持的培训和研究贡献将有助于使 Melissa Suter 博士成为一名成功的独立研究者。