Optical Imaging of the Pulmonary Airways in the Assessment of Lung Cancer

肺气道光学成像在肺癌评估中的应用

• 批准号: 8311819
• 负责人: Melissa J Suter
• 金额: $ 24.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-02 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311819
• 关键词: Accounting; Attention; Award; Biological; Biopsy; Bronchoscopes; Bronchoscopy; Cancer Etiology; Carcinoma in Situ; Catheters; Cessation of life; Classification; Clinic; Clinical; Clinical Research; Clinical Trials; Conduct Clinical Trials; Custom; Detection; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Dysplasia; Early Diagnosis; Environment; Ethics; Evaluation; Family suidae; Feasibility Studies; Fostering; Foundations; Frequencies; Future; General Hospitals; Goals; High Prevalence; Histopathology; Image; Image Guided Biopsy; Imaging Techniques; Imaging technology; Instruction; International; Lasers; Lead; Lesion; Lobectomy; Lung; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Massachusetts; Medical Imaging; Melissa; Mentors; Mentorship; Methods; Microinvasive; Microscopic; Mucous Membrane; Natural History; Operative Surgical Procedures; Optics; Pathology; Pathway interactions; Patient Schedules; Patients; Phase; Pilot Projects; Procedures; Process; Pulmonary Pathology; Pulmonology; Research; Research Personnel; Research Project Grants; Research Training; Resected; Resolution; Safety; Screening procedure; Sensitivity and Specificity; Specimen; Squamous cell carcinoma; Survival Rate; System; Techniques; Testing; Tissues; Training; Validation; Work; authority; base; career; design; design and construction; experience; imaging probe; in vivo; lung imaging; medical schools; mortality; optical imaging; outcome forecast; safety study; safety testing; success; tool

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer related death. Arising in the bronchial mucosa, squamous cell carcinoma (SCC) is currently difficult to detect early in the disease process. For this reason it is typically well advanced upon discovery providing patients little hope of cure. The research focus of this proposal is to develop and test an accurate screening and assessment tool for the detection and diagnosis of squamous cell carcinoma, and its precursor lesions, in the pulmonary airways. It is hoped that through early detection, diagnosis and consequent treatment the mortality rate associated with the disease can be greatly reduced. This research project is based on a newly developed optical imaging technique termed optical frequency domain imaging (OFDI). OFDI is a noninvasive imaging technology that provides cross-sectional images of biological tissues in resolutions comparable with histopathology. We hypothesize that OFDI will be capable of comprehensively imaging the pulmonary airways at microscopic resolutions and, based on the acquired images, we will be able to accurately differentiate and diagnose SCC and its precursor lesions. During the mentored phase of this award, OFDI diagnostic criteria for the evaluation of bronchial pathology will be established, and a custom OFDI imaging probe will be developed and tested. In the independent phase of the award, an OFDI guided-biopsy paradigm with laser marking will be developed and tested, and a subsequent clinical trial to demonstrate the feasibility of the guided-biopsy paradigm will be conducted. Research training will be a core component of this award proposal during the mentored phase with the primary purpose of providing the candidate with a strong foundation in pulmonary medicine and pathology to supplement her existing expertise in medical imaging and biomedical optics. Training will take place at the Wellman Center for Photomedicine, Massachusetts General Hospital under the mentorship of Drs Guillermo Tearney and Brett Bouma, both considered international authorities in optical diagnostics, and at the Lahey Clinic under the direction of Dr. John Beams, an international leader in interventional pulmonary medicine. This training will be further supplemented with formal coursework at Harvard Medical School, and Massachusetts General Hospital. The training and research contributions supported by this K99/ROO award will serve to establish Dr. Melissa Suter as a successful independent investigator.

描述（由申请人提供）：肺癌是癌症相关死亡的主要原因。目前，在疾病过程的早期很难检测到鳞状细胞癌（SCC）在支气管粘膜（SCC）中引起的。因此，发现患者几乎没有治愈的希望，通常会很好地提出。该提案的研究重点是在肺气道中开发和测试用于检测和诊断鳞状细胞癌及其前体病变的准确筛查和评估工具。希望通过早期检测，诊断和随之而来的治疗，与疾病相关的死亡率可以大大降低。该研究项目基于一种新开发的光学成像技术，称为光频域成像（OFDI）。 OFDI是一种无创成像技术，在与组织病理学相当的分辨率中提供了生物组织的横截面图像。我们假设OFDI将能够在微观分辨率上全面成像肺气道，并且根据获得的图像，我们将能够准确地区分和诊断SCC及其前体病变。在该奖项的指导阶段，将建立OFDI诊断标准，以评估支气管病理学，并将开发和测试定制OFDI成像探针。在该奖项的独立阶段，将开发和测试带有激光标记的OFDI指导型型范式，并将进行随后的临床试验，以证明将进行指导二型范式的可行性。研究培训将是该奖励阶段中该奖项提案的核心组成部分，其主要目的是为候选人提供肺部医学和病理学的强大基础，以补充她在医学成像和生物医学光学方面的现有专业知识。培训将在吉列尔莫·塔尼（Guillermo Tearney）博士的指导下，在马萨诸塞州的摄影医学中心，马萨诸塞州综合医院和布雷特·布玛（Brett Bouma）的指导下，均被视为光学诊断的国际当局，在介入肺部医学的国际领导者约翰·比姆斯（John Beams）的指导下，在拉赫伊诊所的指导下。该培训将进一步补充哈佛医学院和马萨诸塞州综合医院的正式课程。该K99/ROO奖支持的培训和研究贡献将旨在建立Melissa Suter博士作为成功的独立研究员。