Training in Inflammation and Nutritional Dysfunction

炎症和营养功能障碍培训

• 批准号: 8237029
• 负责人: SHARON Marie DONOVAN
• 金额: $ 8.04万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8237029
• 关键词: Functional disorder; Inflammation; Nutritional; Training

DESCRIPTION (provided by applicant): This is a resubmission of a competing continuation of a Kirschstein Institutional NRSA on "Inflammation and Nutritional Dysfunction", which was established in 2002. The program is administered by the interdisciplinary Nutritional Sciences program at the University of Illinois, Urbana-Champaign (UIUC) and integrates recognized areas of excellence at UIUC, Nutritional Sciences, Integrative Immunology and Behavior and Gastrointestinal Innate and Adaptive Immunity. While the interdependency between nutrition and immunology long has been appreciated, the complex interaction between the neural, endocrine and immune systems and how they are modulated by environmental factors only recently have begun to be elucidated. Inflammatory mechanisms are central to the pathophysiology of many chronic diseases for which diet is used for prevention or treatment. Thus, it is essential that mechanisms underlying the complex interactions between nutritional status and inflammation be elucidated. The "Inflammation and Nutritional Dysfunction" training program provides comprehensive education at the interface of nutritional sciences and cellular and molecular immunology, with the objective of preparing predoctoral and postdoctoral fellows to become productive, independent scientists capable of furthering the need of NIH to understand the complex interactions between the nutritional status, the innate and adaptive immune systems, and health and disease. In just 4 years, a robust training program has been established, exemplified by an exceptionally strong biomedical research base, success in recruiting underrepresented minorities and students pursuing combined Ph.D./M.D. degrees, and the establishment of the Integrative Immunology and Behavior program at UIUC. Dr. Robert Dantzer, an internationally-recognized leader in the area of psychoneuroimmunology, has been recruited to direct the Integrative Immunology and Behavior program and has been added as a preceptor. Eight preceptors with active research programs focused on nutrition and inflammation provide the core for the training program. Four predoctoral and two postdoctoral fellowships are requested. Candidates with exceptional academic credentials and research experience will be recruited and underrepresented minorities and M.D./Ph.D. candidates will continue to be specifically targeted for enrollment. Research training will be complemented by coursework in nutrition, immunology, endocrinology, neuroscience, biochemistry and molecular biology, a weekly seminar series and presentations at scientific conferences. The strong research programs of the preceptors, the excellent reputation of the Nutritional Sciences program and outstanding intellectual environment at the University of Illinois combine to form an ideal climate in which to train future leaders in this unique interdisciplinary field.

描述（由申请人提供）： This is a resubmission of a competing continuation of a Kirschstein Institutional NRSA on "Inflammation and Nutritional Dysfunction", which was established in 2002. The program is administered by the interdisciplinary Nutritional Sciences program at the University of Illinois, Urbana-Champaign (UIUC) and integrates recognized areas of excellence at UIUC, Nutritional Sciences, Integrative免疫学和行为以及胃肠道先天和适应性免疫。尽管长期以来营养与免疫学之间的相互依赖性得到了人们的认识，但神经，内分泌和免疫系统之间的复杂相互作用以及仅最近才被环境因素调节它们是如何开始阐明的。炎症机制对于许多用于预防或治疗的慢性疾病的病理生理学是核心。因此，必须阐明营养状况和炎症之间复杂相互作用的基础机制。 “炎症和营养功能障碍”培训计划在营养科学以及细胞和分子免疫学的界面上提供了全面的教育，目的是准备摄取量和博士后研究员，使其生产力，独立的科学家成为NIH的能力，以使NIH的需求能够促进NIH的互动，以了解营养和适时的疾病，适时地，适用于适当的疾病，适用于适当的疾病。在短短的4年中，已经建立了一个强大的培训计划，以极强的生物医学研究基础为例，成功地招募了代表性不足的少数民族和攻读合并博士学位的学生。学位，以及在UIUC建立综合免疫学和行为计划。罗伯特·丹策（Robert Dantzer）博士是心理肌免疫学领域的国际公认领导者，已被招募来指导综合免疫学和行为计划，并已被添加为一个受体。具有营养和炎症的八个主动研究计划的八个受体为培训计划提供了核心。请求四个毒品和两个博士后研究金。具有卓越的学术证书和研究经验的候选人将被招募和代表性少少数民族以及医学博士/ph.D。候选人将继续专门针对入学。研究培训将由营养，免疫学，内分泌学，神经科学，生物化学和分子生物学的课程补充，科学会议的每周一次研讨会和演讲。官员的强大研究计划，营养科学计划的良好声誉以及伊利诺伊大学的杰出知识环境结合在一起，形成了一个理想的气候，在这种情况下，在这个独特的跨学科领域中训练未来的领导者。

项目成果

IL-4 Knock Out Mice Display Anxiety-Like Behavior.

• DOI: 10.1007/s10519-015-9714-x
• 发表时间: 2015-07
• 期刊: BEHAVIOR GENETICS
• 影响因子: 2.6
• 作者: Moon, Morgan L.;Joesting, Jennifer J.;Blevins, Neil A.;Lawson, Marcus A.;Gainey, Stephen J.;Towers, Albert E.;McNeil, Leslie K.;Freund, Gregory G.
• 通讯作者: Freund, Gregory G.

Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

• DOI: 10.1523/jneurosci.0704-12.2012
• 发表时间: 2012-10-03
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Chiu GS;Chatterjee D;Darmody PT;Walsh JP;Meling DD;Johnson RW;Freund GG
• 通讯作者: Freund GG

Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities.

• DOI: 10.1186/s12986-018-0294-7
• 发表时间: 2018
• 期刊: Nutrition & metabolism
• 影响因子: 4.5
• 作者: Bray JK;Chiu GS;McNeil LK;Moon ML;Wall R;Towers AE;Freund GG
• 通讯作者: Freund GG

Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A.

• DOI: 10.1371/journal.pone.0000511
• 发表时间: 2007-06-06
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Guest CB;Hartman ME;O'Connor JC;Chakour KS;Sovari AA;Freund GG
• 通讯作者: Freund GG

Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.

• DOI: 10.1038/oby.2011.73
• 发表时间: 2011-08
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Lavin, Desiree N.;Joesting, Jennifer J.;Chiu, Gabriel S.;Moon, Morgan L.;Meng, Jia;Dilger, Ryan N.;Freund, Gregory G.
• 通讯作者: Freund, Gregory G.