Origins and Biological Consequences of Human Infertility

人类不孕症的起源和生物学后果

• 批准号: 8267981
• 负责人: LINDA C GIUDICE
• 金额: $ 211.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267981
• 关键词: Address; Adult; Affect; Area; Biological; California; Career Choice; Child; Clinical; Communities; Community Outreach; Competence; Computational Biology; Data Analyses; Development; Diagnosis; Disease; Education and Outreach; Embryo; Embryonic Development; Endometrium; Event; Fertility; Fertilization; Functional disorder; Germ Cells; Goals; Health; Health Professional; Human; Human Development; Infertility; Informatics; Longevity; Medicine; Mentors; Mission; Molecular; Molecular Analysis; National Institute of Child Health and Human Development; Oocytes; Pathogenesis; Patients; Pilot Projects; Placentation; Post-Transcriptional Regulation; Pregnancy; Pregnancy Outcome; Public Health; Quality of life; Reproduction; Reproductive Biology; Reproductive Health; Reproductive Medicine; Research; Research Personnel; San Francisco; Science; Scientist; Seminal; Staging; Students; System; Techniques; Technology; Translating; Translations; United States National Institutes of Health; Universities; Vision; Woman; adverse outcome; career development; endometriosis; epigenomics; implantation; improved; innovation; next generation; novel diagnostics; novel strategies; novel therapeutics; prevent; programs; reproductive; stem cell biology; trophoblast

This renewal of our NIH U54 SCCPIR Center at the University of California, San Francisco proposes a transdisciplinary, team science approach to elucidate mechanisms underlying seminal events in early development as they relate to the origins and biological consequences of human infertility. Our investigators focus on the developmental continuum from oocyte competence to embryo and placental development to implantation and promote a shared vision of excellence and innovation in reproductive research, advanced technologies, informatics data analyses, mentoring, and community engagement. We combine powerful experimental techniques, system approaches and computational analyses to address critical questions at the intersection of stem cell biology, epigenomics, and clinical reproductive medicine. To accomplish these goals, we have proposed four highly interactive projects by established investigators and one pilot project with a new investigator, which are supported by three cores. Project I (Marco Conti) focuses on mechanisms controlling oocyte developmental competence and early embryo development; Project II (Susan Fisher) will investigate a molecular analysis of the early stages of trophoblast differentiation; Project III (Robert Blelloch) focuses on post-transcriptional regulation of trophoblast differentiation; Projec IV (Linda Giudice) will investigate development of human endometrium for embryonic implantation; and the Pilot Project (NamTran) proposes to investigate molecular mechanisms underlying the pathogenesis and pathophysiology of endometriosis, a common disorder in women associated with infertility and poor pregnancy outcomes These projects are supported by Core A for administration (Linda Giudice), Core B for computational biology research (Jun Song), and Core C for education and community outreach (Synthia Mellon). Our long-term goals are to understand mechanisms underlying normal and abnormal early development fundamentally and for developing novel strategies to diagnose, prevent and treat infertility; optimize fertility and pregnancy outcomes and minimize adverse outcomes; educate aspiring students, the public, health care professionals and patients about human development and disorders associated with abnormal development; and inspire career choice and nurture career development in this important area of reproductive health and research These goals are consistent with the mission of the NICHD.

旧金山加利福尼亚大学 NIH U54 SCCPIR 中心的更新提出了一种跨学科的团队科学方法，以阐明早期发育中的重大事件的潜在机制，因为它们与人类不孕的起源和生物学后果有关。我们的研究人员专注于从卵母细胞能力到胚胎和胎盘发育到植入的发育连续体，并促进生殖研究、先进技术、信息学数据分析、指导和社区参与方面的卓越和创新的共同愿景。我们结合强大的实验技术、系统方法和计算分析来解决干细胞生物学、表观基因组学和临床生殖医学交叉领域的关键问题。为了实现这些目标，我们提出了由现有研究者提出的四个高度互动的项目和由新研究者提出的一个试点项目，并得到三个核心的支持。项目 I（Marco Conti）专注于控制卵母细胞发育能力和早期胚胎发育的机制；项目 II（Susan Fisher）将研究滋养层分化早期阶段的分子分析；项目 III（Robert Blelloch）专注于滋养层分化的转录后调控； Projec IV（Linda Giudice）将研究用于胚胎植入的人类子宫内膜的发育；试点项目 (NamTran) 提议研究子宫内膜异位症发病机制和病理生理学的分子机制，子宫内膜异位症是一种与不孕和妊娠结局不良相关的女性常见疾病。这些项目得到了管理核心 A (Linda Giudice) 和计算核心 B 的支持。生物学研究（Jun Song），以及用于教育和社区外展的核心 C（Synthia Mellon）。我们的长期目标是从根本上了解正常和异常早期发育的机制，并制定诊断、预防和治疗不孕症的新策略；优化生育能力和妊娠结局并尽量减少不良后果；对有抱负的学生、公众、医疗保健专业人员和患者进行关于人类发育和与发育异常相关的疾病的教育；激励职业选择并培育生殖健康和研究这一重要领域的职业发展这些目标与 NICHD 的使命是一致的。