The same dysarthria in different languages: Hypokinetic dysarthria in English and

不同语言中的相同构音障碍：英语和英语中的运动减退性构音障碍

• 批准号: 8433747
• 负责人: Yunjung Kim
• 金额: $ 14.29万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-13 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433747
• 关键词: Acoustics; Address; Affect; American; Characteristics; Classification; Classification Scheme; Clinical; Clinical Management; Clinical assessments; Data; Data Reporting; Diagnosis; Dimensions; Disease; Dysarthria; Equipment and supply inventories; Etiology; Evaluation; Flaccid Muscle Tone; Goals; Hypokinesia; Impairment; Individual; Joints; Judgment; Knowledge; Koreans; Label; Language; Lead; Lesion; Light; Linguistics; Link; Maps; Measures; Motor; Motor Neurons; Nature; Nervous System Physiology; Output; Parkinson Disease; Patients; Pattern; Perception; Phonetics; Production; Property; Reporting; Research; Research Project Grants; Signal Transduction; Site; Speech; Speech Acoustics; Speech Disorders; Speech Intelligibility; Speech Sound; Stimulus; Stress; Symptoms; System; Time; Uncertainty; Variant; Voice; Weight; base; experience; foreign language; indexing; insight; motor control; nervous system disorder; neuropathology; neurophysiology; novel strategies; phonology; predictive modeling; research study; sound; theories

DESCRIPTION (provided by applicant): Our knowledge of dysarthria is largely based on neuropathophysiologic labels such as flaccidity, or hypokinesia, which are assumed to "explain" speech production characteristics (and associated intelligibility deficits). However, this theory has been recently challenged by experimental data reporting mismatches between neuropathophysiology and speech characteristics. In addition, the fact that the majority of dysarthria studies have been conducted on speakers of American English also contributes to the uncertainty about the link between neuropathology and speech output. To address this concern, this project proposes an examination of the effect of native languages on speech characteristics of a single, often-studied dysarthria. The assumption of this approach is that it can shed light on the distinction between language-universal aspects of dysarthria and language-specific aspects of dysarthria. First, we propose obtaining acoustic and intelligibility measures within two languages (American English and Korean) to yield a closely matched set of acoustic measures and construct acoustically-based predictive models of speech intelligibility, within each language. For this aim, acoustic analysis will be performed on utterances produced by English-speaking and Korean-speaking individuals with Parkinson disease and hypokinetic dysarthria. The predictive models of speech intelligibility will be compared between the two languages, with the hypothesis that the weights of the variables contributing to speech intelligibility variation will differ between languages. We also propose to investigate a second perceptual aspect of speech of Parkinson disease, as judged by listeners who respond to utterances both in their native and non-native languages. For this aim, listeners will be asked to rate multiple speech dimensions of speakers with hypokinetic dysarthria, while listening to utterances they understand (native language match between speakers and listeners) and utterances they do not understand (mismatch between native language of speakers and listeners). The results from this novel approach to dysarthria are expected 1) to extend our fundamental knowledge about the nature of dysarthria, and 2) to provide a theoretical basis as to why speech/language variations should be considered in clinical assessment and management of dysarthria. PUBLIC HEALTH RELEVANCE: The proposed project will address language-universal and language-specific characteristics of dysarthria in Parkinson disease, and advance a line of research to broaden our knowledge about the relationship between neuropathology and speech output. It is hoped that insights from this project will also lead to the clinical consideration of speech/language variations in diagnosis and management of speech disorders.

描述（由申请人提供）：我们对纹章障碍的了解主要基于神经病理生理标签，例如宽敞的或低动力学，这些标签被认为可以“解释”语音生产特征（以及相关的可理解性缺陷）。然而，最近，神经病理生理学和语音特征之间的实验数据报告不匹配的实验数据报告了这一理论。此外，大多数构音障碍研究都对美国英语的人进行了这一事实，这也导致了关于神经病理学与言语输出之间联系的不确定性。 为了解决这一问题，该项目提出了对母语对单一，经常研究的构音障碍的言语特征的影响的检查。这种方法的假设是，它可以阐明构音障碍的语言 - 宇宙方面与构音障碍特定方面之间的区别。首先，我们建议在两种语言（美国英语和韩语）中获得声学和清晰度措施，以产生一套紧密匹配的声学措施，并在每种语言中构建基于声学的语音可理解性的预测模型。为此，将对患有帕金森氏病和低迷肌音障碍的说英语和讲朝鲜语的人产生的话语进行声学分析。两种语言之间将比较语音清晰度的预测模型，以及以下假设：有助于语音可理解性变化的变量的权重在语言之间会有所不同。我们还建议调查帕金森氏病言语的第二个感知方面，这是由听众对他们的母语和非本地语言的言论进行判断的。为此，将要求听众评估说话者的多个语音尺寸，并以低为主题的构想障碍，同时倾听他们理解的话语（讲话者和听众之间的母语匹配）和他们不理解的话语（说话者和听众的母语之间的不匹配）。 预计这种新型构音障碍方法的结果是1）扩展我们对构音障碍性质的基本知识，以及2）提供理论上的依据，说明为什么在构想构想障碍和管理中应考虑语音/语言变化。 公共卫生相关性：拟议的项目将解决帕金森氏病构想障碍的语言和语言特定特征，并进步一系列研究，以扩大我们对神经病理学和言语输出之间关系的了解。希望该项目的见解也将导致临床考虑 语音障碍诊断和管理中的语音/语言变化。