Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve

生物膜活性和牙科树脂复合组合物对开发的影响

基本信息

批准号：
8509662
负责人：
Clifton M Carey
金额：
$ 30.13万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-10 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8509662
关键词：
Agreement American Area Biological Factors Bioreactors Charge Chemicals Composite Dental Resin Country Defect Dental Enamel Dental Pellicle Dental caries Dentin Dentists Dependence Development Environment Enzymes Etiology Evaluation Exposure to Failure Fluorides Fourier Transform Fracture Goals Ions Lead Length Lesion Life MALDI-TOF Mass Spectrometry Maps Measures Methods Microbe Microbial Biofilms Microradiography Microscopic Minerals Modeling Nuclear Magnetic Resonance Nutrient Oral Plant Resins Polarization Microscopy Process Production Property Role Salivary Sampling Scanning Electron Microscopy Secondary to Services Shapes Simulate Spectrometry Spectroscopy, Fourier Transform Infrared Staining method Stains Streptococcus mutans Stress Surface Testing Thin Layer Chromatography Time Tooth structure Width Work X-Ray Computed Tomography Xenobiotics analytical method base composite restoration cost crosslink demineralization density dental resin esterase interfacial macromolecule novel polymerization shrinkage prevent public health relevance remineralization restoration restorative dentistry simulation success tooth surface

项目摘要

DESCRIPTION (provided by applicant): The primary objectives of this project are to better understand the factors that lead to the development of secondary caries and to identify strategies to increase the service life of resin composite restorations. Restoration replacements due to secondary caries occupies a large portion of the dentist's practices. In 1999, 86 million composites were placed by dentists in this country and 122.7 million in 2006. The average replacement time is now only 5.7 years. Significant improvements in the long-term integrity of so many restorations could save the American people (by reducing costs of replacing restorations) many times the amount of money required to support this work. There is tremendous significance in the successful pursuit of this endeavor to benefit so many millions of people. We propose to study the effects of biofilm activity and dental resin composite compositions on the development of secondary caries. We will use a bioreactor model that utilizes conditions found in the oral environment to understand the role of microbial biofilms, salivary pellicles, and cyclic loading in the processes of secondary caries formation. While the bioreactor model establishes the conditions for the cyclic remineralization/demineralization attacks, we will use a variety of oral-simulating challenges and analytical methods to assess their effects on composite-restored teeth. We hypothesize that major contributors to defects at restoration margins include: interfacial stresses from contractions induced by polymerization shrinkage of resins, salivary esterases, acidogenic microbe-generated biofilms, and deformations from cyclic loading and oral thermal fluctuations. These can lead to subsequent staining, secondary caries, fractures, or other problems. The long-term goals of this project are to identify and prepare an optimally cross-linking composite composition resin that can restore defective teeth and defy environmental degradation (Aim 1); determine the effects of polymerization shrinkage on the development of degradation at the tooth-composite interface (Aim 2); understand the roles of salivary pellicles and microbial biofilms in the etiology of secondary caries' association with composite restorations (Aim 3); and develop beneficial biofilms in synergy with fluoride therapies that have the potential of retarding the onset of secondary caries (Aim 4). Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations. PUBLIC HEALTH RELEVANCE: This project is focused on developing strategies to increase the service life of resin composite restorations. Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations.

描述（由申请人提供）：该项目的主要目标是更好地了解导致次要龋齿发展的因素，并确定策略以提高树脂复合修复体的使用寿命。由于继发性龋齿而导致的恢复替代者占据了牙医的大部分实践。 1999年，牙医在该国放置了8600万个复合材料，2006年将1.227亿个复合材料放置。现在的平均替代时间仅为5。7年。许多修复体的长期完整性的重大改善可以为美国人民（通过降低替换修复体的成本）挽救多次支持这项工作所需的资金数量。成功地追求这项努力使这么数百万人受益，这具有巨大的意义。我们建议研究生物膜活性和牙齿树脂复合材料组成对次龋齿发展的影响。我们将使用一个生物反应器模型，该模型利用在口腔环境中发现的条件来了解微生物生物膜，唾液颗粒和循环负荷在次生龋齿形成过程中的作用。尽管生物反应器模型建立了环状回忆/脱矿化攻击的条件，但我们将使用各种口服示例挑战和分析方法来评估其对复合材料 - 遗产牙齿的影响。我们假设在恢复边缘缺陷的主要贡献者包括：由树脂，唾液酯酶，酸性微生物生成的生物膜产生的聚合收缩引起的收缩的界面应力，以及来自环状负荷和口服热波动的变形。这些可能导致随后的染色，次要龋齿，裂缝或其他问题。该项目的长期目标是识别和准备最佳的交联综合组成树脂，该树脂可以恢复有缺陷的牙齿并无视环境降解（AIM 1）；确定聚合收缩对牙齿复合界面降解发展的影响（AIM 2）；了解唾液颗粒和微生物生物膜在继发性龋齿与复合修复体相关的病因中的作用（AIM 3）；并与具有延迟次生龋齿发作的氟化物疗法协同作用发展有益的生物膜（AIM 4）。我们的目标是了解决定恢复时间长度的物理，化学和生物学因素。有了这种理解，我们将开发出更稳定的基于树脂的复合材料和方法，以防止衰减限制复合修复体的成功。公共卫生相关性：该项目的重点是制定策略来提高树脂复合修复体的使用寿命。我们的目标是了解决定恢复时间长度的物理，化学和生物学因素。有了这种理解，我们将开发出更稳定的基于树脂的复合材料和方法，以防止衰减限制复合修复体的成功。