Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins

氧杂环丙烷-丙烯酸酯系统可将修复树脂的临床使用寿命延长一倍

基本信息

批准号：
8610770
负责人：
H. RALPH RAWLS
金额：
$ 43.7万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8610770
关键词：
Accounting Acrylates Address Animals Anti-Bacterial Agents Award Bacteria Biochemical Biocompatible Materials Biomedical Engineering Bisphenol A-Glycidyl Methacrylate Calcium Characteristics Chemical Engineering Clinical Clinical Research Clinical Services Color Composite Dental Resin Delayed Hypersensitivity Dental Dental Enamel Dental Pulp Dental caries Dentin Dentistry Doctor of Philosophy Environment Esters Ethylene Oxide Event Exposure to Fatigue Filler Fluorine Goals Hydrolysis Hydrophobicity Hydroquinones Hypersensitivity In Situ In Vitro Incidence Ions Life Longevity Mastication Mechanics Methacrylates Microbial Biofilms Minerals Modeling Nature One-Step dentin bonding system Oral Oral cavity Oral health Oral mucous membrane structure Oxygen Performance Plant Resins Polymer Chemistry Polymers Predisposition Property Recurrence Relaxation Residual state Resistance Science Scientist Side Silver Solid Stress Structure Surface System Testing Urethane Viscosity Water Work analog antimicrobial bacterial resistance base biomaterial compatibility bisphenol A cost crosslink dental resin design dioxirane esterase hydroquinone in vivo innovation inorganic phosphate irritation meetings monomer multidisciplinary nanoparticle novel physical property polymerization public health relevance response restoration restorative dentistry restorative resins triethylene glycol dimethacrylate uptake

项目摘要

Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins Abstract: In order to develop a novel restorative system with at least twice the lifetime of Bis-GMA/TEGDMA- based composites, their incomplete cure and susceptibility to hydrolysis and esterase degradation must be overcome. To address these problems, we will develop a novel superhydrophobic, degradation-resistant, dental restorative based on an Oxirane/Acrylate interpenetrating network System (OASys, pronounced Oasis). These novel monomers based on fluoridated urethanes with either dioxirane or diacrylate functionality can be highly converted to form a hydrophobic, degradation-resistant, tough and resilient interpenetrating polymer network (IPN) that is inherently highly crosslinked. By their nature, these characteristics impart low residual stresses, high resistance to hydrolytic and enzymatic degradation, and biocompatibility. We will also develop a novel one-step (primer-less), "smart," antimicrobial bonding resin with in situ-generated, colorless and color stable, silver nanoparticles (AgNPs). The bonding resin will contain a phosphate group plus both oxirane and acrylate functionalities. The oxirane and acrylate functionalities bond to the corresponding functionalities in the IPN resin matrix for potentially a much stronger bond than the conventional methacrylate system. The phosphate group will allow the bonding resin to wet etched mineral surfaces as well as bond directly to calcium in Ca-phosphate mineral structures. In the event of marginal gap formation, the "smart" in situ-generated AgNPs will release Ag+ ions and create an antibacterial environment, thereby further reducing the incidence of recurrent caries. Five specific aims are proposed: 1. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin mechanical properties, physical properties and in vitro biocompatibility. The more promising compositions will be combined with reinforcing filler and used for Aim 2. 2. To determine the effect of using a 4- Phospho-NPG GA oxirane (4POA)-based bonding system and in situ-generated silver nanoparticles (AgNP) on bonding resin mechanical properties, physical properties, and in vitro biocompatibility and antibacterial activity, as well as on bond strength to oxirane/acrylate interpenetrating network composites.. The two best- performing composites will be chosen for subsequent aims. 3. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to the oral biochemical environment. The two best- performing groups chosen in Aim 2 will be fatigue- and wear-tested after exposure to acidic, basic and esterase-containing environments for 90 days. 4. To determine the effect of using oxiranes, increased hydrophobicity, and IPNs on resin resistance to bacterial degradation. The two best-performing groups from Aim 2 will be tested in an artificial mouth bacterial biofilm model. 5. To determine the in vivo biocompatibility of the OASys. The best performing OASys will be tested in three in vivo biocompatibility models: delayed-type hypersensitivity, oral mucosa irritation, and pulp and dentin response tests. 1