Novel Vehicle for Topical Delivery of Corticosteroids

皮质类固醇局部给药的新型载体

• 批准号: 6549778
• 负责人: H. RALPH RAWLS
• 金额: $ 10万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-05 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549778
• 关键词: antiinflammatory agents; clinical research; corticosteroids; drug delivery systems; drug design /synthesis /production; drug screening /evaluation; drug vehicle; human subject; skin disorder; skin pharmacology; surface coating; topical drug application

DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be cosmetically unacceptable. While efficacy has been shown to be increased with the use of hydrocolloid occlusive dressings, these dressings are often associated with local side effects and inherent cosmetic deficiencies. The goal of this project is to demonstrate the feasibility of using a novel coating technology as a topical delivery vehicle for corticosteroids that simultaneously serve as a semi-occlusive dressing. Coatings impregnated with corticosteroid will be formulated and tested to demonstrate efficacy in the vasoconstrictor assay in humans. PROPOSED COMMERCIAL APPLICATION: Topical corticosteroids are the most widely used preparations in dermatology. A novel vehicle that could improve efficacy and reduce treatments while being cost-effective would have significant commercial potential.

描述（由申请人提供）：外用皮质类固醇是治疗多种皮肤病的有效方法。大多数外用皮质类固醇以霜剂或软膏剂形式使用，需要多次使用，容易被无意去除，并且在美容上可能不可接受。虽然使用水胶体闭塞敷料可以提高疗效，但这些敷料通常会带来局部副作用和固有的美容缺陷。 该项目的目标是证明使用新型涂层技术作为皮质类固醇的局部输送载体的可行性，同时充当半闭塞敷料。将配制并测试浸渍有皮质类固醇的涂层，以证明在人体血管收缩试验中的功效。 拟议的商业应用：外用皮质类固醇是皮肤科中使用最广泛的制剂。一种可以提高疗效、减少治疗次数、同时具有成本效益的新型载体将具有巨大的商业潜力。