The effectiveness of copper surfaces in reducing healthcare acquired infections

铜表面在减少医疗保健获得性感染方面的有效性

• 批准号: 8497625
• 负责人: Daniel Zachary Uslan
• 金额: $ 39.07万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8497625
• 关键词: effectiveness; copper; surfaces; reducing; healthcare

DESCRIPTION (provided by applicant): Healthcare-associated infections (HAIs) are among the leading causes of preventable death in the United States, and are associated with substantial morbidity, mortality, and financial costs. Treatment of HAIs has become increasingly difficult as antimicrobial resistance has increased and the number of effective antimicrobial agents has declined, and prevention of HAIs is thus of critical importance. The hospital clinical environment serves as a reservoir for the spread of nosocomial pathogens, most commonly via the hands of healthcare workers. Reducing these environmental reservoirs has been shown to reduce the incidence of HAIs but is difficult to assess and sustain. This project will explore a novel strategy to decrease HAIs through reduction of environmental reservoirs by replacement of intensive care unit (ICU) high touch surfaces with an inherently antimicrobial surface, copper. Copper has been shown both in vitro and in clinical environments to kill microorganisms such as MRSA and C. difficile on contact. The overall approach will be to conduct a prospective, randomized, double blind clinical trial assessing the efficacy of copper touch surfaces compared with two control surfaces at decreasing the incidence of HAIs (Aim 1). The copper surfaces will be compared to standard conventional surfaces and to copper-tinted stainless steel control surfaces. The microbial burden of the surfaces will be assessed and compared to confirm that reductions in HAIs are due to reductions in bacterial counts. If copper is effective in reducing HAIs, it is critical to consider the cost-effectiveness of refitting intensive care units with coppr surfaces. To assess the benefits and costs of the intervention, we will conduct a cost- effectiveness analysis (Aim 2) from the medical center perspective to assess how sustainable this intervention may be for medical centers. If copper touch surfaces are found to reduce the incidence of HAIs, and especially if the costs are favorable, these studies could lead to more effective and cost-efficient ways of reducing the incidence of HAIs. This project therefore addresses the recent focus of AHRQ on novel approaches to prevention and reduction of healthcare-associated infections.

描述（由申请人提供）：医疗保健相关感染 (HAI) 是美国可预防死亡的主要原因之一，并与大量的发病率、死亡率和财务成本相关。随着抗菌药物耐药性的增加和有效抗菌药物数量的减少，医院感染的治疗变得越来越困难，因此预防医院感染至关重要。医院临床环境是医院病原体传播的储存库，最常见的是通过医护人员的手传播。减少这些环境水库已被证明可以减少 HAI 的发生率，但难以评估和维持。该项目将探索一种新策略，通过用固有抗菌表面铜替换重症监护病房 (ICU) 的高接触表面，减少环境水库，从而减少医院感染。铜在体外和临床环境中均被证明可以杀死接触后的微生物，例如 MRSA 和艰难梭菌。总体方法将是进行一项前瞻性、随机、双盲临床试验，评估铜触摸表面与两个对照表面相比在降低 HAI 发生率方面的功效（目标 1）。铜表面将与标准传统表面和铜色不锈钢控制表面进行比较。将评估和比较表面的微生物负荷，以确认 HAI 的减少是由于细菌数量的减少。如果铜能有效减少 HAI，那么考虑用铜表面改装重症监护室的成本效益就至关重要。为了评估干预措施的效益和成本，我们将从医疗中心的角度进行成本效益分析（目标 2），以评估该干预措施对于医疗中心的可持续性。如果发现铜触摸表面可以降低 HAI 的发生率，特别是在成本有利的情况下，这些研究可能会带来更有效且更具成本效益的方法来降低 HAI 的发生率。因此，该项目解决了 AHRQ 最近关注的预防和减少医疗保健相关感染的新方法的重点。