Center for Polycystic Kidney Disease Research at Yale

耶鲁大学多囊肾病研究中心

• 批准号: 8723388
• 负责人: Michael J. Caplan
• 金额: $ 2.51万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723388
• 关键词: Affect; Animal Model; Biological Markers; Clinical Trials; Collaborations; Confocal Microscopy; Country; Data Set; Development; Disease; Disease Progression; Fluorescence Microscopy; Fostering; Funding; Genetic; Goals; Health Services Research; Human; Image; Individual; Institution; Investigational Therapies; Ion Channel; Kidney; Kidney Failure; Laser Microscopy; Measures; Medical Students; Methodology; Methods; Microscopy; Modeling; Molecular; Monitor; Mus; Natural History; Patients; Physiological; Polycystic Kidney Diseases; Postdoctoral Fellow; Property; Proteins; Proteome; Proteomics; Renal Replacement Therapy; Reporting; Research; Research Personnel; Research Training; Resolution; Resources; Services; Specimen; Staging; Surrogate Endpoint; Therapeutic; Time; Training; Training Programs; Translational Research; Translations; Treatment Protocols; Urine; Zebrafish; base; disease-causing mutation; graduate student; immunocytochemistry; indexing; interest; mouse model; new technology; preclinical study; programs; tool; translational approach; translational study; two-photon

The principal goal of the Center for Polycystic Kidney Disease Research at Yale is to facilitate translational research that will advance the understanding and treatment of polycystic kidney diseases. The Center will provide investigators both at Yale and across the country with access to highly specialized services and research tools not otherwise routinely available to support their research. Three Center Cores will be established whose specific objectives are to 1) generate, maintain and provide small animal models of polycystic kidney disease, 2) provide detailed characterizations of the proteomic profiles of urine specimens derived from these mouse models during the course both of disease progression and of experimental therapies, and 3) offer polycystic kidney disease researchers access to advanced physiological tools, including characterization of ion channel activities and state of the art imaging facilities, with which to explore the cellular and molecular basis of polycystic kidney disease. We have identified a research user base of 31 investigators, including 11 at outside institutions, who have expressed specific interest in using core services of the Polycystic Kidney Disease Center at Yale. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of polycystic kidney disease research, and to foster basic and translational studies directly related to polycystic kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among investigators participating in the Center; facilitate the application of new technologies to polycystic kidney disease research; and provide an online index of resources developed in the Center (e.g. mouse and zebrafish models and urine proteomes) so that they can be made available to polycystic kidney disease investigators both at Yale and at other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in polycystic kidney disease research in general, and in the specialized models and methodologies provided by the Center Cores in particular.

耶鲁大学多囊肾病研究中心的主要目标是促进转化研究，以促进对多囊肾病的理解和治疗。该中心将为耶鲁大学和全国各地的研究人员提供高度专业化的服务和研究工具，而这些服务和工具通常无法用于支持他们的研究。将建立三个中心核心，其具体目标是 1) 生成、维持和提供多囊肾病的小动物模型，2) 提供疾病进展过程中这些小鼠模型的尿液样本的蛋白质组学特征的详细表征和实验疗法，3）为多囊肾病研究人员提供先进的生理学工具，包括离子通道活性的表征和最先进的成像设施，以探索多囊肾病的细胞和分子基础。我们已经确定了由 31 名研究人员组成的研究用户群，其中 11 名来自外部机构，他们对使用耶鲁大学多囊肾病中心的核心服务表示出特别的兴趣。将建立一个试点和可行性计划，为年轻研究人员提供初始项目资金，吸引新的研究人员进入多囊肾疾病研究领域，并促进与多囊肾疾病直接相关的基础和转化研究。此外，还将设立一项强化计划，以促进参与该中心的研究人员之间的跨学科互动和合作；促进新技术在多囊肾病研究中的应用；并提供该中心开发的资源的在线索引（例如小鼠和斑马鱼模型以及尿液蛋白质组），以便耶鲁大学和其他机构的多囊肾病研究人员可以使用它们。该中心还将包括一项研究培训计划，以加强对研究生、医学生和博士后研究员在多囊肾病研究方面的培训，特别是在中心核心提供的专门模型和方法方面的培训。