Pain Sensitivity in Low Back Pain

腰痛的疼痛敏感性

• 批准号: 8419958
• 负责人: Angela Renee Starkweather
• 金额: $ 42.18万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-20 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8419958
• 关键词: Acute; Address; Affect; American; Americas; Biological; Biological Assay; Biological Markers; Candidate Disease Gene; Characteristics; Clinical; Cohort Studies; Detection; Development; Diagnosis; Environmental Risk Factor; Etiology; Frequencies; Future; Gene Expression; Gene Expression Profile; Genes; Genetic; Genetic Polymorphism; Health; Health Care Costs; Healthcare; Inflammatory; Intervention; Knowledge; Lead; Low Back Pain; Measures; Membrane; Modification; Nervous system structure; Neuraxis; Neurons; Nociceptors; Outcome; Pain; Participant; Pathway interactions; Patients; Peripheral; Personal Satisfaction; Productivity; Protocols documentation; Public Health; Quality of life; Reporting; Research; Research Personnel; Risk; Role; Sensory; Signal Transduction; Signaling Molecule; Synapses; System; Testing; Time; Treatment Efficacy; United States; Woman; Work; case control; cofactor; disability; effective intervention; experience; improved; mRNA Expression; men; prevent; prospective; psychosocial; public health relevance; receptor; research study; response; time use; trait

DESCRIPTION (provided by applicant): Low back pain is the second most frequently diagnosed pain condition in the United States and even after receiving health care treatment an estimated 40% of patients will experience persistent low back pain. Accurate detection of patients at increased risk for persistent low back pain and the delivery of effective interventions could save the United States billions of dollars each year in health care expenses and lost productivity, and improve quality of life for millions of Americans. Although a precise structural etiology of persistent low back pain is rarely present, recent studies report functional alteration in the peripheral and central nervous system of patients with persistent low back pain that are associated with enhanced pain sensitivity. It has recently been shown that genetic polymorphisms and modifications in gene expression patterns can influence pain sensitivity; however, this has never been studies in patients with low back pain. Therefore, the proposed study will investigate the role of enhanced pain sensitivity on the risk of persistent LBP through characterization of pain sensitivity and pain-sensitivity candidate gene profiling.

描述（由申请人提供）：腰痛是美国第二频繁诊断出的疼痛状况，即使接受医疗保健治疗后，估计有40％的患者也会经历持续的下腰痛。准确检测持续性下背痛风险增加的患者和有效干预措施 每年可以节省美国数十亿美元的医疗保健费用，失去生产力，并改善数百万美国人的生活质量。尽管很少出现持续性下腰痛的精确结构性病因，但最近的研究报告了持续性下腰痛患者的外周和中枢神经系统的功能改变，这与疼痛敏感性增强有关。最近已经显示，基因表达模式的遗传多态性和修饰会影响疼痛敏感性。但是，这从来没有研究过腰痛患者。因此，拟议的研究将通过表征疼痛敏感性和疼痛敏感性候选基因分析来研究增强疼痛敏感性对持续LBP风险的作用。