Washington Area Comprehensive Sickle Cell Center

华盛顿地区综合镰状细胞中心

• 批准号: 7821241
• 负责人: SOHAIL RANA
• 金额: $ 40.98万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-18 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7821241
• 关键词: Washington; Area; Comprehensive; Sickle; Cell

DESCRIPTION (provided by applicant): The proposed Washington Area Comprehensive Sickle Cell Center includes Howard University, a historically-black teaching institution in the nation's capital, Children's National Medical Center, the premier provider of healthcare to children with sickle cell disease (SCD) in the area, and the Vascular Medicine Branch of NHLBI, an internationally recognized unit that leads in the investigation of the vascular complications of SCD. The proposed Center also includes collaboration with Ahmadu Bello University in Zaria, Nigeria, an institution that treats many SCD patients who have not yet been exposed to blood transfusions or hydroxyurea. The primary focus of the proposed center is to improve understanding, prevention and treatment of the vascular complications of SCD. The components of the project are: 1. An inter-Center Phase II Study of therapy with a nitric oxide-donating combination compared to an angiotensin converting enzyme inhibitor or placebo in preventing renal dysfunction, pulmonary hypertension, stroke and other complications in SCD patients with systemic systolic blood pressure of 120-139 mm Hg. 2. An intra-Center clinical study to determine the prevalence of pulmonary hypertension in Nigerian SCD patients using echocardiographic measurements of the tricuspid regurgitant jet velocity, the contribution of HIV/AIDS and malaria, and the role of genetic polymorphisms in candidate genes that regulate endothelial function and adhesion. 3. A patient services research project to identify the prevalence of developmental problems among infants and toddlers with SCD compared to age and demographically matched controls. 4. A translational research project that seeks to raise levels of HDL and therefore apoA-1 to improve endothelium-dependent vasorelaxation by administration of the NAD precursor, niacin. 5. An Administrative Core. 6. A Clinical Core that includes the adult and pediatric sickle cell clinics at Howard University, the pediatric sickle cell clinic at Children's National Medical Center, the adult sickle cell clinic at NHLBI, and their associated personnel. 7. A Patient Services Core focusing on education, community outreach, genetic counseling and diagnostic testing. 8. A Sickle Cell Scholar Component.

描述（由申请人提供）：拟议的华盛顿地区综合镰状细胞中心包括霍华德大学（美国首都的一所历史悠久的黑人教学机构）、儿童国家医疗中心（儿童国家医疗中心），该中心是为患有镰状细胞病 (SCD) 的儿童提供医疗保健的主要机构NHLBI 的血管医学分部是国际公认的单位，负责 SCD 血管并发症的研究。拟议的中心还包括与尼日利亚扎里亚的艾哈迈杜贝洛大学合作，该机构治疗许多尚未接触过输血或羟基脲的 SCD 患者。拟建中心的主要重点是提高对 SCD 血管并发症的认识、预防和治疗。该项目的组成部分是： 1. 一项中心间 II 期研究，研究与血管紧张素转换酶抑制剂或安慰剂相比，使用一氧化氮捐赠组合治疗可预防全身收缩压为 120-120 的 SCD 患者的肾功能不全、肺动脉高压、中风和其他并发症。 139 毫米汞柱。 2. 一项中心内临床研究，通过超声心动图测量三尖瓣反流射流速度、艾滋病毒/艾滋病和疟疾的影响以及调节内皮细胞的候选基因中遗传多态性的作用来确定尼日利亚 SCD 患者肺动脉高压的患病率。功能和附着力。 3. 一项患者服务研究项目，旨在与年龄和人口统计匹配的对照组相比，确定患有 SCD 的婴儿和幼儿中发育问题的患病率。 4. 一项转化研究项目，旨在通过施用 NAD 前体烟酸来提高 HDL 水平，从而提高 apoA-1 水平，从而改善内皮依赖性血管舒张作用。 5. 行政核心。 6. 临床核心，包括霍华德大学的成人和儿童镰状细胞诊所、儿童国家医疗中心的儿童镰状细胞诊所、NHLBI 的成人镰状细胞诊所及其相关人员。 7. 患者服务核心，重点关注教育、社区外展、遗传咨询和诊断测试。 8. 镰状细胞学者组件。