Estimation and Correction of Ultrasound Beam Aberration Caused by Breast

乳腺引起的超声束像差的估计与校正

• 批准号: 8470094
• 负责人: ROBERT C WAAG
• 金额: $ 32.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470094
• 关键词: Acoustics; Algorithms; Anatomic structures; Behavior; Breast; Breast Diseases; Characteristics; Clinical; Data; Detection; Development; Diagnosis; Dimensions; Electronics; Fatty acid glycerol esters; Financial compensation; Focused Ultrasound Therapy; Generations; Histocompatibility Testing; Histologic; Image; Imaging Techniques; Investigation; Knowledge; Lighting; Link; Location; Magnetic Resonance; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Measurement; Measures; Methods; Modeling; Monitor; Morphology; Performance; Phase; Physiologic pulse; Procedures; Process; Property; Protons; Recurrence; Relaxation; Research; Resolution; Roswell Park Cancer Institute; Scanning; Severities; Severity of illness; Shapes; Signal Transduction; Simulate; Source; Specimen; Speed; Structure; System; Techniques; Testing; Time; Tissue Model; Tissues; Ultrasonic Transducer; Ultrasonic wave; Ultrasonography; Universities; Validation; Variant; Water; attenuation; base; data acquisition; density; design; digital models; image reconstruction; improved; instrument; malignant breast neoplasm; novel; public health relevance; response; simulation; sound; statistics; success; transmission process; two-dimensional; virtual

DESCRIPTION (provided by applicant): The objective of this research is to develop ultrasound propagation algorithms and tissue models that mimic ultrasound scattering behavior in typical breast specimens for use in studying breast imaging techniques, and then to employ these models and algorithms to refine and evaluate adaptive focusing methods that correct for ultrasound beam aberration caused by propagation through breast inhomogeneities. The specific aims are to: 1) acquire high-resolution magnetic resonance imaging data throughout the volume of the breast and segment the data into tissue types with acoustic properties characterized by random processes, 2) calculate acoustic propagation in three dimensions through the modeled volume of the breast to determine the aberration produced by inhomogeneities in the breast, 3) perform pulse-echo measurements of aberration using the same specimens to validate the modeling of the breast and the calculation of aberration, and 4) simulate high-resolution b-scan images by using adaptive focusing that compensates for aberration. The segmented data will be used to develop realistic numerical models for calculations of propagation. Calculations of pulse propagation through the breast models will use three-dimensional k-space and fast multiple methods. Propagation through the models will be used to simulate measurements that are repeatable and easy to alter, allowing for efficient refinement of aberration-correction methods. Aberration will be determined using two new algorithms. In one algorithm, the aberration is estimated using cross spectra of pulse-echo signals obtained from a set of focuses in an isoplanatic region. In the other algorithm, aberration is estimated using cross correlation of echoes obtained from broad-beam illuminations produced by virtual sources. Variations of the parameters that govern these algorithms will be explored to optimize algorithm performance. Simulated point-reflector echoes received through the aberration path will be used to compute the true aberration for comparison with the aberration found using the two algorithms. The true focus achieved in each of the cases will be described by calculations and also by hydrophone measurements. Focus characteristics as well as image resolution will be evaluated with respect to breast morphology in the propagation paths. Arrival time fluctuations, waveform shape changes, and statistics of distortion will be determined for both calculated and measured results. Also, the size of the region over which aberration can be satisfactorily compensated with a single set of parameters will be determined. Focus characteristics and image resolution will be carefully evaluated and critically compared to available geometric and adaptive focusing techniques. Quantitative conclusions about the effects of aberration in ultrasound imaging of the breast and the performance of the two aberration correction algorithms will be developed. As a result of this research, adaptive focusing techniques using aberration correction will yield improved resolution that will significantly increase the capability of ultrasound b-scan imaging to distinguish between normal and diseased breast tissue and to determine the severity of breast disease in circumstances not now possible with ultrasound.

描述（由申请人提供）：这项研究的目的是开发超声传播算法和组织模型，这些模型在典型的乳房标本中模仿超声散射行为，用于研究乳房成像技术，然后采用这些模型和算法来改善并评估通过乳腺外观来纠正超声束的适应性焦点方法，以通过乳腺造成的胸腔来构成乳腺外观。具体目的是：1）在整个乳房的整个体积中获取高分辨率的磁共振成像数据，并将数据分为组织类型，具有以随机过程为特征的声学特性，2）通过模型的乳房来计算三个维度的乳房中的乳房，以确定乳房的乳房模型，以确定乳房模型，均具有脉搏脉冲，3）乳房和畸变的计算，以及4）通过使用补偿像差的自适应聚焦来模拟高分辨率B扫描图像。分段数据将用于开发用于传播计算的现实数值模型。通过乳房模型的脉冲传播计算将使用三维K空间和快速多种方法。通过模型传播将用于模拟可重复且易于更改的测量结果，从而有效地完善了像差校正方法。畸变将使用两种新算法确定。在一种算法中，使用从等星形区域的一组焦点获得的脉冲 - 回声信号的横光估算畸变。在其他算法中，使用从虚拟来源产生的宽光束照明获得的回波的跨相关性来估计畸变。将探索控制这些算法的参数的变化以优化算法性能。通过畸变路径收到的模拟点反射回声将用于计算真正的畸变，以与使用两种算法发现的像差进行比较。在每种情况下实现的真正焦点将通过计算以及水文测量来描述。将评估焦点特征和图像分辨率，以相对于传播路径中的乳房形态进行评估。到达时间波动，波形形状的变化以及计算结果和测量结果将确定失真的统计数据。同样，将确定可以通过一组参数令人满意补偿的区域的大小。将焦点特性和图像分辨率与可用的几何和适应性聚焦技术进行仔细评估和认真评估。关于像畸变在乳房超声成像中的影响以及两种像差校正算法的性能的定量结论。这项研究的结果是，使用像差校正的自适应聚焦技术将产生改进的分辨率，这将显着提高超声B扫描成像的能力，以区分正常和患病的乳房组织，并在超声波上无法确定乳房疾病的严重程度。