6th International Workshop on Seizure Prediction

第六届癫痫发作预测国际研讨会

• 批准号: 8597679
• 负责人: BRUCE J GLUCKMAN
• 金额: $ 2.3万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597679
• 关键词: Address; Advertising; Area; Attention; Biological; Brain; Clinical; Collaborations; Communities; Development; Devices; Educational workshop; Electroencephalography; Electrophysiology (science); Engineering; Epilepsy; Equipment; Funding; Generations; Goals; International; Intervention; Lead; Measures; Metric; Modeling; Neocortex; Neurons; Neurosciences; Neurosciences Research; Neurosurgeon; Organism; Participant; Physiological; Research Personnel; Seizures; Site; Societies; Syndrome; System; Time; Travel; base; cost; interdisciplinary approach; meetings; neurophysiology; novel; novel strategies; public health relevance; symposium; theories; therapy development

DESCRIPTION (provided by applicant): The overall objective of this effort is to convene the Sixth International Workshop on Seizure Prediction, a forum that brings together an international interdisciplinary group involving epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists focused on the development of treatments for epilepsy especially based on closed loop prediction and interventions. While this goal has not changed, the group has recognized that the focus of attention needs to shift away from a biological mechanism-free algorithmic approach to EEG and related electrophysiology recordings, and toward a better understanding of underlying physiological mechanisms as they specifically relate to clinical recordings. At a fundamental level, the goal of seizure prediction is to identif the underlying mechanisms of seizure generation and to engineer systems that will detect those dynamics and provide for intervention. This meeting will focus attention on basic questions at the intersection of engineering, computational and epilepsy neuroscience necessary for predicting and intervening with seizures: how seizures arise in the neocortex, how to identify sites of seizure origination, how seizures spread, and how they terminate. We have identified these topics as key roadblocks to further advances in treatment of pharmacoresistant epilepsy syndromes. Through these questions we will focus attention on bridging clinical and physiological metrics to arrive at new approaches to understand epileptic seizure generation mechanisms across all scales of brain from neuron to organism, and especially close the loop between models of seizure generation and physiological observations.

描述（由申请人提供）：这项工作的总体目标是召集第六届癫痫发作预测的国际研讨会，该论坛汇集了一个涉及癫痫学家，工程师，物理学家，数学家，神经科学家和神经科学家的国际跨学科小组癫痫的治疗尤其是基于闭环预测和干预措施。尽管该目标尚未改变，但该小组已经认识到，注意力的重点需要从无生物机制的脑电图和相关电生理记录中转变，并更好地了解潜在的生理机制，因为它们特别与临床有关录音。在基本层面上，癫痫发作预测的目的是识别癫痫发作的基本机制，以及将检测这些动态并提供干预的工程系统。这次会议将把注意力集中在工程，计算和癫痫神经科学的交集上，以预测和干预癫痫发作所需的必要：新皮层中的癫痫发作，如何识别癫痫发作的位置，癫痫发作的传播方式以及如何终止。我们已经将这些主题确定为关键障碍，以进一步治疗药物抑制癫痫综合征。通过这些问题，我们将注意力集中在桥接临床和生理指标上，以了解新的方法，以了解从神经元到生物体的所有大脑范围内的癫痫发作产生机制，尤其是在癫痫发作产生和生理观察模型之间循环。