UNC Clinical Translation Science Award-K12 Scholars Program (KL2)

北卡罗来纳大学临床翻译科学奖 - K12 学者计划 (KL2)

• 批准号: 8667518
• 负责人: MARSCHALL S. RUNGE
• 金额: --
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-19 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8667518
• 关键词: Award; Basic Science; Caring; Charge; Clinical; Clinical Oncology Supplement (K12); Clinical Pathways; Clinical Research; Clinical Sciences; Commit; Communities; Community Physician; Development; Discipline; Disincentive; Educational Activities; Educational Curriculum; Educational Models; Educational process of instructing; Educational workshop; Ensure; Environment; Faculty; Fostering; Funding; Funding Agency; Future; Goals; Grant; Home environment; Hybrids; Individual; Institutes; Institution; Institutional Policy; Interdisciplinary Study; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Link; Medical; Mentors; Methodology; Metric; Mission; Modeling; NCI Scholars Program; North Carolina; Participant; Policies; Population; Private Sector; Process; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rewards; Role; Schools; Science; Scientist; Secure; Side; Structure; Students; Training; Training Programs; Training and Education; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Work; bench to bedside; career; career development; clinical practice; design; experience; innovation; member; novel; peer; population based; programs; research and development; skills; success

UNC-CH has created an environment in which the training and career development of junior investigators is a very high priority. In the last 10 years, support from the NIH (K30, 53 T32s, and 6 K12s) as well as from a variety of other funding sources has allowed us to establish a career development program that has been employed as a template for the creation of similar programs at other institutions. Our commitment to young investigators is evident in the recruitment and retention of stellar junior scientists, many of whom have gone on to secure mentored K awards (25 K01s, 18 K08s, and 23 K23s). In addition, junior faculty members from UNCCH have received 5 of the 100 K99/ROO grants awarded by the NIH during the past year. Much of this success is attributable to the Office of Research and Career Development, an entity established to support the careers of our junior investigators. Indeed, this Office has become a model for many of our peer institutions. Despite the success we have enjoyed to date, it has become quite clear that if we are to fulfill the mission of both the NIH Roadmap and the TraCS Institute (i.e., accelerating the translation of scientific discoveries from the laboratory to the bedside and then on to the community), we must create a hew training model, one that breaks down the existing single-discipline silo structure, diversifies our research teams, and redefines our traditional metrics of success. We must expand the number and diversity of trainees, drawing individuals from a variety of disciplines, academic levels (undergraduates through faculty), types of science (basic, clinical, population-based), roles on the team (leader, co-investigator, project manager), and venues (UNC-CH, other universities in the state, the community, the private sector). Only in an environment where the educational culture is already quite mature could such a radical institutional aim (i.e., creating truly modern hybrid research teams fully committed to translating scientific discovery),be proposed. The CTSA Roadmap, with the goal of moving new discoveries from the laboratory bench to the bedside and ultimately into clinical practice, presents an opportunity to transform our educational model in novel ways. The goal of this Education, Training, and Career Development (ETCD) Core is to reinvigorate and redirect our current transformational wave by establishing within the TraCS Institute a centralized administrative home for the training and career development of clinical and translational researchers. Under the aegis of this interdisciplinary multi-school institute, we are proposing a variety of new strategies that are designed to train research professionals who are fully committed to clinical and translational research and who can bridge the divide between basic and clinical discovery. Our Core will then help to assemble them into the interdisciplinary research teams that will utilize the resources of the TraCS Institute to pursue the hybrid science that is so . critical if we are to make scientific discovery a tangible part of medical care.

UNC-CH创造了一个环境，在该环境中，初级调查人员的培训和职业发展是一个 优先级。在过去的10年中，NIH（K30，53 T32和6 K12）的支持以及 其他各种资金来源使我们能够建立一个职业发展计划 用作在其他机构创建类似程序的模板。我们对年轻的承诺 调查人员在招募和保留恒星初级科学家方面很明显，其中许多人继续进行 确保指导的K奖（25 K01，18 K08和23 K23）。此外，来自UNCCH的初级教师 在过去的一年中，已收到了NIH授予的100 k99/Roo赠款中的5个。大部分成功 归因于研究与职业发展办公室，这是一个建立的实体，以支持职业 我们的初级调查员。确实，这个办公室已成为我们许多同行机构的典范。 尽管我们迄今为止一直很成功，但很明显，如果我们要履行使命 NIH路线图和TRACS研究所都（即，加速了科学发现的翻译 床边的实验室，然后到达社区），我们必须创建一个HEW培训模型，该模型是 分解现有的单学院筒仓结构，使我们的研究团队多样化，并重新定义我们的 成功的传统指标。我们必须扩大学员的数量和多样性，吸引个人 各种学科，学术水平（通过教师的本科生），科学类型（基本，临床， 基于人群的），团队中的角色（领导者，共同投资者，项目经理）和场地（UNC-CH，其他 该州，社区，私营部门的大学）。仅在教育的环境中 文化已经很成熟，可能是如此激进的机构目标（即创建真正的现代混合研究 建议完全致力于翻译科学发现）。 CTSA路线图，目的是将新发现从实验室长凳转移到床边 最终进入临床实践，为以新颖的方式改变了我们的教育模式的机会。这 这种教育，培训和职业发展（ETCD）核心的目标是重新振奋和重定向我们 当前的变革浪潮通过在TRACS研究所内建立一个集中的行政住所 临床和转化研究人员的培训和职业发展。在这方面 跨学科的多学院研究所，我们提出了各种旨在培训的新策略 完全致力于临床和转化研究的研究专业人员，可以桥接 在基本发现和临床发现之间进行划分。然后，我们的核心将有助于将它们组装成跨学科 将利用TRACS Institute资源的研究团队来追求如此的混合科学。 如果要使科学发现成为医疗保健的切实部分，至关重要。

项目成果

Non-publication of large randomized clinical trials: cross sectional analysis.

• DOI: 10.1136/bmj.f6104
• 发表时间: 2013-10-29
• 期刊: BMJ (Clinical research ed.)
• 作者: Jones CW;Handler L;Crowell KE;Keil LG;Weaver MA;Platts-Mills TF
• 通讯作者: Platts-Mills TF

Effect of comorbidity on risk of venous thromboembolism in patients with renal cell carcinoma.

合并症对肾细胞癌患者静脉血栓栓塞风险的影响。

• DOI: 10.1016/j.urolonc.2013.07.008
• 发表时间: 2014
• 期刊: Urologic oncology
• 作者: Smith,AngelaB;Horvath-Puhó,Erzsébet;Nielsen,MatthewE;Lash,TimothyL;Baron,JohnA;Sørensen,HenrikT
• 通讯作者: Sørensen,HenrikT

Increase in older adults reporting mountaineering-related injury or illness in the United States, 1973-2010.

1973 年至 2010 年，美国报告登山相关伤害或疾病的老年人数量增加。

• DOI: 10.1016/j.wem.2012.08.014
• 发表时间: 2013
• 期刊: Wilderness & environmental medicine
• 影响因子: 1.4
• 作者: Platts-Mills,TimothyF;Hunold,KatherineM
• 通讯作者: Hunold,KatherineM

Exploring youth and caregiver preferences for asthma education video content.

• DOI: 10.3109/02770903.2015.1057847
• 发表时间: 2016
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Geryk LL;Arrindell CC;Sage AJ;Blalock SJ;Reuland DS;Coyne-Beasley T;Lee C;Sleath BL;Carpenter DM
• 通讯作者: Carpenter DM

Comparison of seven-day and repeated 24-hour recall of symptoms in the first 100 days after hematopoietic cell transplantation.

造血细胞移植后前 100 天内 7 天和重复 24 小时症状回忆的比较。

• DOI: 10.1016/j.jpainsymman.2014.06.011
• 发表时间: 2015
• 期刊: Journal of pain and symptom management
• 影响因子: 4.7
• 作者: Wood,WilliamA;Deal,AllisonM;Bennett,AntoniaV;Mitchell,SandraA;Abernethy,AmyP;Basch,Ethan;Bailey,Charlotte;Reeve,BryceB
• 通讯作者: Reeve,BryceB