Biodiversity surveys in Indonesia and discovery of health and energy solutions

印度尼西亚生物多样性调查以及健康和能源解决方案的发现

基本信息

批准号：
8702461
负责人：
Kyria Boundy-Mills
金额：
$ 19.35万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8702461
关键词：
AIDS/HIV problem Academy Address Agreement Animals Area Arthropods Bacteria Biocompatible Materials Biodiversity Biological Factors Biota Birds Cellulases Charge Collection Complex Data Deposition Development Disease Education and Outreach Educational workshop Ensure Enzymes Equipment and supply inventories Ethics Expeditions Federal Government Feedback Forestry Goals Government Officials Group Structure Guidelines Health Human Human Resources Immune System Diseases Indonesia Industry Insecta Institutes Institution International Invertebrates Island Knowledge Lead Lipids Local Government Mammals Metric Microbe Modeling Molds Multimedia Museums Natural Resources Nature Online Systems Organism Participant Pattern Pharmacologic Substance Plant Leaves Plant Roots Plants Policies Principal Investigator Process Production Property Rain Recommendation Recording of previous events Research Resources Sampling San Francisco Schedule Science Scientist Secure Series Shipping Ships Site Soil Solutions Southeastern Asia Specimen Structure Sulawesi Surveys Technology Technology Transfer Telecommunications Therapeutic Therapeutic Agents Time Training Transcription Factor AP-1 United Nations Universities Vascular Plant Vertebrates Work Yeasts addiction base benefit sharing cancer addiction cancer therapy cellulase data sharing design experience forest fungus improved knowledge base material transfer agreement meetings microbial novel novel therapeutics plant fungi preclinical study product development programs screening sound

项目摘要

DESCRIPTION (provided by applicant): The simultaneous study, conservation, and sustainable use of natural resources in tropical biodiversity hotspots require collaborative research partnerships of unprecedented scope and complexity, and the alarming rate at which biodiversity is being lost in many tropical regions has resulted in an urgent need for such efforts. We have assembled a multi-disciplinary, multi-institutional, international team to address the following objectives: 1) undertake surveys of biodiversity present in select taxonomic groups within the tropical forests of southeastern Sulawesi, a poorly studied yet threatened area of high species endemism within the biodiversity hotspot Wallacea; 2) explore the application of micro- and macro-organisms for natural product development for specific human health and bioenergy issues; 3) use the information from biodiversity surveys to develop recommendations for strategies to conserve endangered biomes and associated traditional and scientific knowledge bases; 4) develop and encourage local conservation planning, education, and outreach efforts that are ecologically, economically, and socio-politically sound; and 5) develop strong, equitable partnerships with effective international agreements relating to technology transfer, materials access, and benefit sharing. The project is organized into six Associate Programs: Macroorganism surveys; Microbial surveys; Discovery of energy solutions; Discovery of human health solutions; Conservation research and vertebrate surveys; and Conservation partnerships, training, and ethics. Our team includes scientists from three US Universities: UC Davis (lead), UC Berkeley, and UC San Francisco, and three prominent Indonesian institutions: Indonesian Institute of Science (lead agency), Indonesian Ministry of Forestry, and Bandung Institute of Technology. We will also form partnerships with private companies aimed at the commercial development of natural products for Pharmaceuticals and energy production, and we have secured collaborators from several other leading research institutions (e.g., Bishop Museum). An Indonesian-based Steering Committee, an International Advisory Board, and a web-based telecommunications and data-sharing network will provide critical guidance and interactive feedback loops for all participants throughout the course of the project. The results of this project will make significant contributions to a broad range of issues, including knowledge of patterns of biodiversity in southeast Asia, identification and isolation of natural products with potential therapeutic value to treat globally important diseases and to address human energy needs, development of effective biodiversity conservation strategies and proactive outreach and education programs to promote those strategies, and establishment of models for effective and equitable international collaborative partnerships and ethical and sustainable international sharing of biogenetic resources.

描述（由申请人提供）：热带生物多样性热点地区自然资源的同步研究、保护和可持续利用需要前所未有的范围和复杂性的合作研究伙伴关系，而许多热带地区生物多样性丧失的惊人速度已导致迫切需要这样的努力。我们组建了一个多学科、多机构的国际团队来实现以下目标：1）对苏拉威西东南部热带森林内选定分类群中存在的生物多样性进行调查，这是一个研究不足但受到威胁的高物种特有地区。生物多样性热点华莱士； 2）探索微生物和宏观生物在天然产物开发中的应用，以解决特定的人类健康和生物能源问题； 3) 利用生物多样性调查的信息制定保护濒危生物群落及相关传统和科学知识库的战略建议； 4) 制定和鼓励对生态、经济和社会政治有利的当地保护规划、教育和推广工作； 5) 通过与技术转让、材料获取和惠益分享相关的有效国际协议，发展牢固、公平的伙伴关系。该项目分为六个副计划：宏观生物体调查；微生物调查；发现能源解决方案；发现人类健康解决方案；保护研究和脊椎动物调查；保护伙伴关系、培训和道德。我们的团队包括来自三所美国大学的科学家：加州大学戴维斯分校（牵头机构）、加州大学伯克利分校和加州大学旧金山分校，以及三所著名的印度尼西亚机构：印度尼西亚科学研究所（牵头机构）、印度尼西亚林业部和万隆理工学院。我们还将与致力于药品和能源生产天然产品商业开发的私营公司建立合作伙伴关系，并且我们已经从其他几个领先的研究机构（例如毕夏普博物馆）获得了合作者。位于印度尼西亚的指导委员会、国际咨询委员会以及基于网络的电信和数据共享网络将为整个项目过程中的所有参与者提供关键指导和交互式反馈循环。该项目的成果将为广泛的问题做出重大贡献，包括了解东南亚生物多样性的模式、识别和分离具有治疗全球重要疾病和满足人类能源需求潜在治疗价值的天然产物、开发有效的生物多样性保护战略和积极主动的外联和教育方案，以促进这些战略，并建立有效和公平的国际合作伙伴关系以及道德和可持续的生物遗传资源国际共享的模式。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways.

DOI：
10.1016/j.ejphar.2013.12.016
发表时间：
2014-02-05
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY
影响因子：
5
作者：
Chen, Haixia;Sohn, Johann;Zhang, Likang;Tian, Jingge;Chen, Shuhan;Bjeldanes, Leonard F.
通讯作者：
Bjeldanes, Leonard F.

Manipulation of culture conditions alters lipid content and fatty acid profiles of a wide variety of known and new oleaginous yeast species.

DOI：
10.1016/j.biortech.2013.06.047
发表时间：
2013-09
期刊：
Bioresource technology
影响因子：
11.4
作者：
Sitepu IR;Sestric R;Ignatia L;Levin D;German JB;Gillies LA;Almada LA;Boundy-Mills KL
通讯作者：
Boundy-Mills KL

An improved high-throughput Nile red fluorescence assay for estimating intracellular lipids in a variety of yeast species.

DOI：
10.1016/j.mimet.2012.09.001
发表时间：
2012-11
期刊：
JOURNAL OF MICROBIOLOGICAL METHODS
影响因子：
2.2
作者：
Sitepu, I. R.;Ignatia, L.;Franz, A. K.;Wong, D. M.;Faulina, S. A.;Tsui, M.;Kanti, A.;Boundy-Mills, K.
通讯作者：
Boundy-Mills, K.

Carbon source utilization and inhibitor tolerance of 45 oleaginous yeast species.