Biodiversity surveys in Indonesia and discovery of health and energy solutions

印度尼西亚生物多样性调查以及健康和能源解决方案的发现

基本信息

批准号：
8702461
负责人：
Kyria Boundy-Mills
金额：
$ 19.35万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8702461
关键词：
AIDS/HIV problem Academy Address Agreement Animals Area Arthropods Bacteria Biocompatible Materials Biodiversity Biological Factors Biota Birds Cellulases Charge Collection Complex Data Deposition Development Disease Education and Outreach Educational workshop Ensure Enzymes Equipment and supply inventories Ethics Expeditions Federal Government Feedback Forestry Goals Government Officials Group Structure Guidelines Health Human Human Resources Immune System Diseases Indonesia Industry Insecta Institutes Institution International Invertebrates Island Knowledge Lead Lipids Local Government Mammals Metric Microbe Modeling Molds Multimedia Museums Natural Resources Nature Online Systems Organism Participant Pattern Pharmacologic Substance Plant Leaves Plant Roots Plants Policies Principal Investigator Process Production Property Rain Recommendation Recording of previous events Research Resources Sampling San Francisco Schedule Science Scientist Secure Series Shipping Ships Site Soil Solutions Southeastern Asia Specimen Structure Sulawesi Surveys Technology Technology Transfer Telecommunications Therapeutic Therapeutic Agents Time Training Transcription Factor AP-1 United Nations Universities Vascular Plant Vertebrates Work Yeasts addiction base benefit sharing cancer addiction cancer therapy cellulase data sharing design experience forest fungus improved knowledge base material transfer agreement meetings microbial novel novel therapeutics plant fungi preclinical study product development programs screening sound

项目摘要

DESCRIPTION (provided by applicant): The simultaneous study, conservation, and sustainable use of natural resources in tropical biodiversity hotspots require collaborative research partnerships of unprecedented scope and complexity, and the alarming rate at which biodiversity is being lost in many tropical regions has resulted in an urgent need for such efforts. We have assembled a multi-disciplinary, multi-institutional, international team to address the following objectives: 1) undertake surveys of biodiversity present in select taxonomic groups within the tropical forests of southeastern Sulawesi, a poorly studied yet threatened area of high species endemism within the biodiversity hotspot Wallacea; 2) explore the application of micro- and macro-organisms for natural product development for specific human health and bioenergy issues; 3) use the information from biodiversity surveys to develop recommendations for strategies to conserve endangered biomes and associated traditional and scientific knowledge bases; 4) develop and encourage local conservation planning, education, and outreach efforts that are ecologically, economically, and socio-politically sound; and 5) develop strong, equitable partnerships with effective international agreements relating to technology transfer, materials access, and benefit sharing. The project is organized into six Associate Programs: Macroorganism surveys; Microbial surveys; Discovery of energy solutions; Discovery of human health solutions; Conservation research and vertebrate surveys; and Conservation partnerships, training, and ethics. Our team includes scientists from three US Universities: UC Davis (lead), UC Berkeley, and UC San Francisco, and three prominent Indonesian institutions: Indonesian Institute of Science (lead agency), Indonesian Ministry of Forestry, and Bandung Institute of Technology. We will also form partnerships with private companies aimed at the commercial development of natural products for Pharmaceuticals and energy production, and we have secured collaborators from several other leading research institutions (e.g., Bishop Museum). An Indonesian-based Steering Committee, an International Advisory Board, and a web-based telecommunications and data-sharing network will provide critical guidance and interactive feedback loops for all participants throughout the course of the project. The results of this project will make significant contributions to a broad range of issues, including knowledge of patterns of biodiversity in southeast Asia, identification and isolation of natural products with potential therapeutic value to treat globally important diseases and to address human energy needs, development of effective biodiversity conservation strategies and proactive outreach and education programs to promote those strategies, and establishment of models for effective and equitable international collaborative partnerships and ethical and sustainable international sharing of biogenetic resources.

描述（由申请人提供）：在热带生物多样性热点中的同时研究，保护和可持续使用自然资源需要进行空前的范围和复杂性的协作研究合作伙伴关系，并且在许多热带地区丧失了生物多样性的令人震惊的速度。我们已经组建了一个多学科的多机构国际团队来解决以下目标：1）对Sulawesi东南部的热带森林中精选分类学群体中存在的生物多样性进行调查，这是一个研究不足的生物多样性Hotspot Wallacea内部较高物种宗教领域的知名却受到威胁的地区； 2）探索微生物和宏观生物在自然产品开发中的应用，用于特定的人类健康和生物能源问题； 3）使用来自生物多样性调查的信息，为保护濒临灭绝的生物群体以及相关的传统和科学知识基础制定建议； 4）制定并鼓励在生态，经济和社会政策上既明智的地方，教育和外展工作''； 5）建立与技术转移，材料访问和福利共享有关的有效国际协议建立强大，公平的合作伙伴关系。该项目分为六个助理计划：宏观生物调查；微生物调查；发现能源解决方案；发现人类健康解决方案；保护研究和脊椎动物调查；以及保护伙伴关系，培训和道德规范。我们的团队包括来自美国三所大学的科学家：加州大学戴维斯分校（LEC），加州大学伯克利分校和加州大学旧金山分校，以及三个著名的印度尼西亚机构：印尼科学学院（主要机构），印度尼西亚林业部和万隆技术学院。我们还将与旨在用于制药和能源生产天然产品的商业开发的私营公司建立合作伙伴关系，并且我们从其他几家主要研究机构（例如Bishop Museum）获得了合作者。基于印尼的指导委员会，国际顾问委员会以及基于网络的电信和数据共享网络将为所有项目的所有参与者提供关键的指导和交互式反馈循环。 The results of this project will make significant contributions to a broad range of issues, including knowledge of patterns of biodiversity in southeast Asia, identification and isolation of natural products with potential therapeutic value to treat globally important diseases and to address human energy needs, development of effective biodiversity conservation strategies and proactive outreach and education programs to promote those strategies, and establishment of models for effective and equitable international collaborative partnerships and ethical and sustainable international sharing of生物遗传资源。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways.

DOI：
10.1016/j.ejphar.2013.12.016
发表时间：
2014-02-05
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY
影响因子：
5
作者：
Chen, Haixia;Sohn, Johann;Zhang, Likang;Tian, Jingge;Chen, Shuhan;Bjeldanes, Leonard F.
通讯作者：
Bjeldanes, Leonard F.

Manipulation of culture conditions alters lipid content and fatty acid profiles of a wide variety of known and new oleaginous yeast species.

DOI：
10.1016/j.biortech.2013.06.047
发表时间：
2013-09
期刊：
Bioresource technology
影响因子：
11.4
作者：
Sitepu IR;Sestric R;Ignatia L;Levin D;German JB;Gillies LA;Almada LA;Boundy-Mills KL
通讯作者：
Boundy-Mills KL

An improved high-throughput Nile red fluorescence assay for estimating intracellular lipids in a variety of yeast species.

DOI：
10.1016/j.mimet.2012.09.001
发表时间：
2012-11
期刊：
JOURNAL OF MICROBIOLOGICAL METHODS
影响因子：
2.2
作者：
Sitepu, I. R.;Ignatia, L.;Franz, A. K.;Wong, D. M.;Faulina, S. A.;Tsui, M.;Kanti, A.;Boundy-Mills, K.
通讯作者：
Boundy-Mills, K.

Carbon source utilization and inhibitor tolerance of 45 oleaginous yeast species.