Cardiovascular Evaluation for the SHS Phase V

SHS V 期心血管评估

• 批准号: 8609108
• 负责人: RICHARD B DEVEREUX
• 金额: $ 2万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-10 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609108
• 关键词: 12p; 15 year old; Adult; American Indians; Area; Arterial Fatty Streak; Atherosclerosis; Biology; Blood Vessels; Calories; Cardiac; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Cessation of life; Characteristics; Chromosomes; Clinical; Cohort Studies; Communities; Development; Diabetes Mellitus; Echocardiography; Electrocardiogram; Energy Metabolism; Evaluation; Event; Family; Family Sizes; Family Study; Foundations; Functional disorder; Funding; Generations; Genes; Genetic; Heart; Heart Atrium; Heart Valve Diseases; Heritability; Heterogeneity; Hypertension; Hypertrophy; Individual; Investigation; Ischemia; Joints; Lead; Left; Left Ventricular Ejection Fraction; Left Ventricular Function; Left Ventricular Hypertrophy; Left Ventricular Mass; Measures; Medial; Methods; Myocardial; Myocardial Ischemia; North America; Organ; Overweight; Participant; Pathogenesis; Peripheral arterial disease; Phase; Phenotype; Pilot Projects; Population; Population Study; Prevalence; Progress Reports; Publications; Recruitment Activity; Relative (related person); Research Personnel; Risk Factors; Sampling; Structure; Structure of popliteal artery; Techniques; Thick; Time; Trees; Tribes; Ultrasonography; Ventricular; Work; abstracting; aged; base; cardiovascular risk factor; cohort; computerized; diabetic; diagnostic accuracy; follow-up; genetic linkage; hemodynamics; improved; indexing; member; mortality; non-diabetic; phase 3 study; phase 4 study; pre-clinical; pressure; prognostic; programs; voltage

DESCRIPTION (provided by applicant): Findings in the first 4 Strong Heart Study (SHS) exams (high rates of diabetes [DM] and cardiovascular [CV] events and heritability of arterial cardiac phenotypes [LOD=5.3 for left ventricular (LV) mass index on chromosome 12p]) identify SHS participants as being of unusual importance in understanding CV disease biology. Carotid exams in participants in SHS Phase IV showed substantial progression of atherosclerosis over 4 years and showed heritability of arterial size and stiffness. Phase IV echo's showed near doubling of 'LV hypertrophy and decline in LV function over 8 years from Phase II. Initial 17¿10 months follow-up showed CV events were predicted strongly by discrete carotid plaque but only weakly by intimal-medial thickness (IMT).In SHS Phase V, 3,060 members >15 years old in 3-generation families will be evaluated by carotid and popliteal ultrasound, computerized ECG and echo measures of LV geometry and function. The characteristics of the SHS population and strengths of the investigative groups lead us to focus this renewal to: 1) establish genetic linkage of carotid artery IMT and discrete plaques; 2) assess linkage of LV mass, geometry and newer measures of LV function; 3) examine heritability of ECG measures of cardiac conduction, voltage and repolarization; 4) assess heritability and linkage of popliteal artery IMT and discrete plaque as measures of peripheral arterial disease; 5) assess the separate and joint effects of DM, overweight and hypertension on development of LV hypertrophy and dysfunction over 4 years from the 4thSHS exam; 6) determine the impacts of DM, overweight and hypertension on progression of carotid IMT and discrete plaques since the 4th SHS exam; 7) relate change in ECG measures of LV hypertrophy Andre polarization to changes in echo LV mass and arterial structure and function; 8) assess the prognostic significance of arterial measures made during the 3rd SHS exam and extend analyses of prognostic significance of previously-measured echo and ECG variables; 9) evaluate changes of arterial structure and function in SHS pilot Family Study participants over 8 years and of echo findings over 12 years in cohort members in the SHS Family Study; 10) examine relations of popliteal artery IMT and discrete a thermos to prevalent overt and sub clinical peripheral arterial disease and CV risk factors and 11) evaluate relations of changes in ECG measures of LV hypertrophy, repolarization and ischemia to morbid and mortal events. (End of Abstract)

描述（由申请人提供）： 在第一个强大的心脏研究（SHS）检查（糖尿病[DM]和心血管[CV]事件的高率和ARTIAC表型的遗传力[左心室（LOD）（LOD = 5.3）中，对左心室（LV）12p染色体上的LOD = 5.3的结果（lod = 5.3）中的结果）确定SHS参与者在理解CV疾病学方面具有不寻常的重要性。 SHS IV期参与者的颈动脉检查在4年内显示了动脉粥样硬化的实质性进展，并显示出动脉大小和僵硬的遗传力。 IV阶段ECHO的LV肥大几乎增加了一倍，而LV功能从II期开始了8年。最初的17史10个月的随访显示，通过离散的颈动脉斑块强烈预测了CV事件，但仅通过Intimal-Media厚度（IMT）弱地预测了CV事件。在SHS阶段V中，3,060名成员> 15岁的3代家族的成员将通过Carotid和Popliteal超声，计算机化的ECH和ECHO测量LV GEOMENT和LV GEOMENTY和功能。 SHS人群的特征和调查群体的优势使我们将这种续签集中在：1）建立颈动脉IMT和离散斑块的遗传联系； 2）评估LV质量，几何形状和LV功能的较新测量的连接； 3）检查心脏传导，电压和复极测量的ECG测量的遗传力； 4）评估popliteal动脉IMT和离散斑块的遗传和联系，作为外围人工制品的度量； 5）评估DM，超重和高血压对4THSHS考试后4年的LV肥大和功能障碍的发育的单独和关节作用； 6）确定自第四款SHS考试以来的DM，超重和高血压对颈动脉IMT和离散斑的进展的影响； 7）将LV肥大的ECG测量Andre极化与回声LV质量以及动脉结构和功能的变化相关联； 8）评估在第三款SHS考试期间采取的动脉措施的预后意义，并扩展了先前测量的Echo和ECG变量的预后意义的分析； 9）评估SHS家族研究参与者的动脉结构和功能的变化，以及在SHS家庭研究中的12年以上的12年以上的回声结果； 10）检查popliteal伪像的关系和离散的热水瓶，以使其普遍存在的明显和临床临床外周动脉疾病和简历危险因素以及11）评估LV肥大，复活性和缺血对病态和致命事件的ECG变化的评估关系。 （抽象的结尾）

项目成果

Codesigning a community-based participatory research project to assess tribal perspectives on privacy and health data sharing: A report from the Strong Heart Study.

• DOI: 10.1093/jamia/ocac038
• 发表时间: 2022-05-11
• 期刊: JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
• 影响因子: 6.4
• 作者: Triplett, Cynthia;Fletcher, Burgundy J.;Taitingfong, Riley, I;Zhang, Ying;Ali, Tauqeer;Ohno-Machado, Lucila;Bloss, Cinnamon S.
• 通讯作者: Bloss, Cinnamon S.

Cadmium and cardiovascular risk.

镉和心血管风险。

• DOI: 10.1097/ede.0b013e31829f613c
• 发表时间: 2013
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Tellez-Plaza,Maria;Guallar,Eliseo;Howard,BarbaraV;Navas-Acien,Ana
• 通讯作者: Navas-Acien,Ana

Ethnic differences in arterial wave reflections and normative equations for augmentation index.

动脉波反射的种族差异和增强指数的规范方程。

• DOI: 10.1161/hypertensionaha.110.166348
• 发表时间: 2011-06
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Chirinos JA;Kips JG;Roman MJ;Medina-Lezama J;Li Y;Woodiwiss AJ;Norton GR;Yasmin;Van Bortel L;Wang JG;Cockcroft JR;Devereux RB;Wilkinson IB;Segers P;McEniery CM
• 通讯作者: McEniery CM