Duke CTSA

杜克大学CTSA

• 批准号: 8467106
• 负责人: ROBERT M CALIFF
• 金额: $ 17.98万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467106
• 关键词: Biological; Child health care; Clinical; Clinical Research; Collaborations; Communities; Continuing Education; County; Data; Disease; Effectiveness; Electronics; Elements; Evaluation; Fostering; Funding; Future; Generations; Genomics; Grant; Health; Health Services Research; Health system; Healthcare Systems; Home environment; Human; Institutes; Instruction; Investigation; Joints; Learning; Link; Measurable; Medical; Medicine; Methods; Mission; Modification; Molecular Analysis; Outcome; Output; Phase; Pilot Projects; Population; Research; Research Personnel; Research Project Grants; Resources; System; Systems Biology; Technology; Training; Training and Education; Translational Research; Translations; United States National Institutes of Health; Work; base; biomedical informatics; care delivery; career development; clinical application; comparative effectiveness; effectiveness research; experience; flexibility; global health; improved; innovation; meetings; next generation; novel; public-private partnership; skills; social; tool; translational medicine

PROJECT SUMMARY (See instructions): The mission of the Duke Translational Medicine Institute (DTMI) is to catalyze translation across the continuum from scientific discovery to clinical research to care delivery and global health. We propose to fulfill this mission by achieving four Specific Aims:1) Implement the next phase of the clinical and translational research at Duke, by enhancing its scope, its operational effectiveness, and the number of researchers it serves; 2) Provide DTMI investigators with biomedical informatics tools and methods needed to enhance the operational effectiveness of this next phase of the DTMI; 3) Train the next generation of clinical and translational research leaders and support continuing education to enhance the skills of the current generation of research leaders; 4) Develop methods and approaches for integrating research results into practice and practice outcomes into research. While we succeeded in building a home for clinical and translational researchers in the first funding cycle of the CTSA grant, recent discussions at the NIH and our own assessments have pointed out the need for further transformation of the system. Major emphasis must be placed on measurable output, project management, enterprise portfolio management, and public-private partnerships. These themes were reflected in the work of the DTMI during our first five years, and we are prepared to accelerate this effort by: implementing innovative approaches to pilot projects, creating a translational technology resource network, and supporting novel methods. A global proof of concept network to study human systems biology is a key element of DTMI. All human research projects in Duke Medicine (over 4,100) will be coordinated within the same electronic management system. Innovative elements of the plan include novel public private partnerships, a highly developed project management system, and an innovative approach to integration of medical, financial, operational, environmental, and social data into a geospatially referenced enterprise data warehouse. This powerful system, combined with tools that enable use of the data in concert with the community, has enabled the planning for a county-wide effort to improve health outcomes while enabling health services research and joint investigation of biological, medical, and social causes of health and disease. Special emphasis will be placed on integration of child health and comparative effectiveness research into DTMI, as well as on health studies that foster both community engagement and analysis of molecular and genomic data in populations. The flexible DTMI approach emphasizes constant evaluation and modifications based on a detailed continuous improvement paradigm.

项目摘要（参见说明）：杜克大学转化医学研究所 (DTMI) 的使命是促进从科学发现到临床研究再到护理服务和全球健康的整个过程的转化。我们建议通过实现四个具体目标来完成这一使命：1）通过扩大杜克大学的范围、运营效率和服务的研究人员数量来实施杜克大学下一阶段的临床和转化研究； 2) 为 DTMI 研究人员提供增强 DTMI 下一阶段运作有效性所需的生物医学信息学工具和方法； 3）培训下一代临床和转化研究领导者，并支持继续教育，以提高当代研究领导者的技能； 4）制定将研究成果融入实践、将实践成果融入研究的方法和途径。虽然我们在 CTSA 拨款的第一个资助周期中成功地为临床和转化研究人员建立了一个家园，但最近 NIH 的讨论和我们自己的评估都指出需要进一步改造该系统。必须重点关注可衡量的产出、项目管理、企业组合管理和公私伙伴关系。这些主题反映在 DTMI 前五年的工作中，我们准备通过以下方式加速这一努力：实施试点项目的创新方法、创建转化技术资源网络以及支持新颖的方法。研究人类系统生物学的全球概念验证网络是 DTMI 的关键要素。杜克大学医学中心的所有人类研究项目（超过 4,100 个）都将在同一电子管理系统内进行协调。该计划的创新要素包括新颖的公私合作伙伴关系、高度发达的项目管理系统以及将医疗、财务、运营、环境和社会数据集成到地理空间参考企业数据仓库中的创新方法。这一强大的系统与能够与社区一起使用数据的工具相结合，能够规划全县范围内改善健康结果的努力，同时能够进行卫生服务研究以及对健康问题的生物、医学和社会原因进行联合调查。健康和疾病。将特别强调将儿童健康和比较有效性研究纳入 DTMI，以及促进社区参与和人口分子和基因组数据分析的健康研究。灵活的 DTMI 方法强调基于详细的持续改进范例的持续评估和修改。

项目成果

Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus.

吲哚美辛与布洛芬治疗动脉导管未闭的有效性和安全性比较。

• 发表时间: 2015-12
• 影响因子: 2.5
• 作者: Gulack, Brian C;Laughon, Matthew M;Clark, Reese H;Sankar, Meera N;Hornik, Christoph P;Smith, P Brian
• 通讯作者: Smith, P Brian

High rates of venous thromboembolic events in patients undergoing systemic therapy for urothelial carcinoma: A systematic review and meta-analysis.

接受尿路上皮癌全身治疗的患者静脉血栓栓塞事件发生率较高：系统评价和荟萃分析。

• 发表时间: 2016-09
• 作者: Gopalakrishna, Ajay;Longo, Thomas A;Fantony, Joseph J;Doshi, Uma;Harrison, Michael R;Van Noord, Megan;Inman, Brant A
• 通讯作者: Inman, Brant A