Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

用于 Cor 光谱 CT 成像的铋有机配合物靶向纳米颗粒

• 批准号: 8497716
• 负责人: Gregory M Lanza
• 金额: $ 19.31万
• 依托单位: OCEAN NANOTECH, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8497716
• 关键词: Accident and Emergency department; Acute; Anatomy; Animals; Arkansas; Attenuated; Beds; Biodistribution; Bismuth; Calcium; Canis familiaris; Cardiac; Cardiac Catheterization Procedures; Cardiovascular system; Chest Pain; Clinical; Collaborations; Complement; Complex; Coronary; Coronary heart disease; Coupling; Decision Making; Deposition; Development; Diagnosis; Disease; Drug Formulations; Drug Kinetics; Epitopes; Etiology; Fibrin; Fibrinogen; Floor; Goals; Healthcare; Heart Diseases; Home environment; Hospitals; Human; Human Development; Image; Immune; Individual; Life; Ligands; Lung; Materials Testing; Medical; Modeling; Musculoskeletal; Myocardial; Nanotechnology; Oceans; Oryctolagus cuniculus; Outcome; Patient Transfer; Patients; Peptides; Pharmacodynamics; Phase; Predictive Value; Preparation; Procedures; Process; Production; Proteins; Recording of previous events; Relative (related person); Research; Research Personnel; Risk; Rupture; Safety; Sterility; Stress Tests; Technology; Telemetry; Thrombosis; Thrombus; Toxic effect; Toxicity Tests; Universities; Validation; Washington; X-Ray Computed Tomography; attenuation; cost; evaluation/testing; follow-up; gastrointestinal; heart imaging; improved; in vivo; innovation; molecular imaging; nanomaterials; nanoparticle; novel; prototype; scale up; stability testing

DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal, we hypothesize that a novel thrombus-specific Spectral Computed Tomography (Multicolored CT) nanoparticle (i.e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma. This project, which is led by Ocean NanoTech in collaboration with Washington University, will complete development of a GLP-/GMP-ready 1- fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND. This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs.

描述（由申请人提供）：出现在急诊科（ED）的患者的胸痛提出了一个临床困境：新兴冠状动脉血运重建的转移，通宵进行心脏遥测和压力测试，或通过医疗随访出院。在该提案中，我们假设一种新型的血栓特异性光谱计算机断层扫描（多色CT）纳米颗粒（即Nanok）方法可以直接快速评估ED中的冠状动脉疾病，这可以帮助解决这一临床困境。该项目由Ocean Nanotech与华盛顿大学合作，将完成适用于GLP/GMP准备的1-纤维蛋白Nanok产品候选者，以适应GLP稳定性和毒性测试，以支持FDA IND。这种Nanok平台技术为诊断和治疗急性冠状动脉疾病提供了独特的好处，可以改善医疗保健结果并降低成本。