2013 MECHANISMS OF MEMBRANE TRANSPORT GRC

2013 GRC膜运输机制

• 批准号: 8595476
• 负责人: Nancy Carrasco
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-06 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8595476
• 关键词: Active Ion Transport; Address; Amino Acid Transporter; Area; Binding; Biochemistry; Biophysics; Ca(2+)-Transporting ATPase; Calmodulin; Cardiac; Cells; Cellular biology; Complex; Computing Methodologies; Consultations; Cystic Fibrosis; Data; Development; Disease; Drug effect disorder; Equation; Event; Faculty; Family; Fertilization; Financial Support; Fostering; Funding; Future; Hand; Hormones; Hour; Hypertension; Hypothyroidism; Individual; Ion Channel; Ions; Kinetics; Laboratories; Left; Lotion; Malabsorption Syndromes; Maltose; Medical; Membrane; Membrane Proteins; Membrane Transport Proteins; Mental Depression; Mentors; Metabolism; Minority; Molecular; Molecular Conformation; Movement; Muscle; Neurons; Nutrient; Organism; Participant; Physiological; Physiology; Plants; Play; Population; Postdoctoral Fellow; Potassium Channel; Process; Property; Proteins; Public Health; Publishing; Rage; Recommendation; Recording of previous events; Recruitment Activity; Regulation; Relative (related person); Research; Research Personnel; Resolution; Retinal; Role; Schedule; Scientist; Senior Scientist; Series; Signal Transduction; Sports; Staging; Structure; Students; Therapeutic Agents; Thermodynamics; Time; Transmembrane Transport; Transport Process; Travel; Walking; Woman; Work; absorption; abstracting; base; design; genetic regulatory protein; graduate student; innovation; insight; interest; lactose permease; meetings; melibiose permease; member; novel; novel strategies; novel therapeutics; planetary Atmosphere; posters; programs; public health relevance; sensor; social; success; sugar; symposium; voltage

DESCRIPTION (provided by applicant): We have planned a Gordon Research Conference that, true to the GRC's distinguished history and tradition, will foster productive and stimulating exchanges of ideas aimed at obtaining a mechanistic understanding of membrane transport processes and their regulation. The field of transporters and channels has seen extraordinary progress in recent years, which bodes well for the timing and likely impact of this meeting. High-resolution structures of membrane proteins have been obtained, spurring a strong interest in functional and mechanistic analyses of these and other transporters, and attracting a new crop of young researchers. The central aim of this conference is to illuminate transport mechanisms by integrating structural data and functional findings. This type of integration is a crucial step toward understanding not only the transporters' function but also their rage- lotion and the role of many of these proteins in disease. This meeting will provide an ideal opportunity for younger investigators to interact extensively with top established scientists in the field, a type of interaction that is difficult to achieve in other settings. The areas to be addressed in the presentations at the conference will include physiology, biochemistry, biophysics, and cell biology. One new subject to be introduced will bring a new transformative perspective to the field: a novel approach to identifying and quantitating intermediates in the transport process, which consists of analyzing kinetic and electrophysiological data using first-principles- based equations to yield the relative populations of the molecular conformational and substrate occupancy states that participate in all stages of transport. We will organize a highly innovative session focused on this approach, where we will discuss thermodynamics, kinetics, and conformational states during transport. The session will also address the use of computational methods to pursue the same questions as well as to provide detailed information about the transitions between conformational states. Our conference will highlight cutting-edge discoveries and will gather promising young scientists and many of the most successful investigators in the field today. Therefore, robust financial support is crucial to the success of this meeting, particularly for recruiting young investigators, including graduate students, postdoctoral fellows, and junior faculty members. The impact that a conference like this can have on their future professional lives cannot be overestimated. Given the key physiological roles of membrane transporters and channels in such processes as ion metabolism, in retinal absorption of nutrients, and signal modulation in neurons, many of the topics to be covered are crucial lee relevant in both the basic and medical realms. A better understanding of the underlying mechanisms of membrane transporters and channels is essential not only for the elucidation of the normal physiology of a host of vital molecules, but also for the development of new therapeutic agents and approaches to a wide variety of diseases, including hypertension, depression, hypothyroidism, malabsorption syndromes, and cystic fibrosis.

描述（由申请人提供）：我们计划了一次戈登研究会议，符合GRC的杰出历史和传统，将促进生产和刺激 旨在获得对膜运输过程及其调节的机械理解的思想交流。近年来，运输者和渠道领域取得了非凡的进步，这在这次会议的时机和可能的影响方面非常好。已经获得了膜蛋白的高分辨率结构，激发了对这些和其他转运蛋白的功能和机械分析的浓厚兴趣，并吸引了新的年轻研究人员。这次会议的核心目的是通过整合结构数据和功能结果来阐明运输机制。这种类型的整合是迈向理解转运蛋白功能的关键步骤，而且是其愤怒和许多这些蛋白质在疾病中的作用。这次会议将为年轻的调查人员提供与该领域顶级科学家进行广泛互动的理想机会，这种互动在其他环境中很难实现。会议演讲中要解决的领域将包括生理学，生物化学，生物物理学和细胞生物学。一个要引入的新主题将为该领域带来一个新的变革性观点：一种新的方法来识别和定量运输过程中的中间体，其中包括使用基于第一原质的方程来分析动力学和电生理数据，以产生在所有阶段参与运输阶段的分子构象和底物占用状态的相对种群。我们将组织一个专注于这种方法的高度创新性会议，在运输过程中，我们将讨论热力学，动力学和构象状态。会议还将解决使用计算方法来提出相同问题的使用，并提供有关构象状态之间过渡的详细信息。我们的会议将重点介绍最先进的发现，并将聚集有前途的年轻科学家和当今该领域的许多最成功的调查员。因此，强大的财政支持对于这次会议的成功至关重要，特别是对于包括研究生，博士后研究员和初级教职员工在内的招募年轻调查员。这样的会议可能会对他们未来的职业生活产生影响。鉴于膜转运蛋白和通道在离子代谢，营养视网膜吸收以及神经元中信号调节等过程中的关键生理作用，许多要涵盖的主题在基本和医学领域都是至关重要的。更好地理解膜转运蛋白和通道的潜在机制，不仅对于阐明许多生命分子的正常生理学至关重要，而且对于开发了新的治疗剂和开发新的治疗剂，以及用于多种疾病的方法，包括高血压，抑郁症，抑郁症，抑郁症，抑郁症，非甲状腺功能障碍，甲状腺素症，马babsorsporsyssyss，anddrymessynsciplys和cycibibristy and cycibristy和cycibibristy。