2013 MECHANISMS OF MEMBRANE TRANSPORT GRC

2013 GRC膜运输机制

• 批准号: 8595476
• 负责人: Nancy Carrasco
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-06 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8595476
• 关键词: Active Ion Transport; Address; Amino Acid Transporter; Area; Binding; Biochemistry; Biophysics; Ca(2+)-Transporting ATPase; Calmodulin; Cardiac; Cells; Cellular biology; Complex; Computing Methodologies; Consultations; Cystic Fibrosis; Data; Development; Disease; Drug effect disorder; Equation; Event; Faculty; Family; Fertilization; Financial Support; Fostering; Funding; Future; Hand; Hormones; Hour; Hypertension; Hypothyroidism; Individual; Ion Channel; Ions; Kinetics; Laboratories; Left; Lotion; Malabsorption Syndromes; Maltose; Medical; Membrane; Membrane Proteins; Membrane Transport Proteins; Mental Depression; Mentors; Metabolism; Minority; Molecular; Molecular Conformation; Movement; Muscle; Neurons; Nutrient; Organism; Participant; Physiological; Physiology; Plants; Play; Population; Postdoctoral Fellow; Potassium Channel; Process; Property; Proteins; Public Health; Publishing; Rage; Recommendation; Recording of previous events; Recruitment Activity; Regulation; Relative (related person); Research; Research Personnel; Resolution; Retinal; Role; Schedule; Scientist; Senior Scientist; Series; Signal Transduction; Sports; Staging; Structure; Students; Therapeutic Agents; Thermodynamics; Time; Transmembrane Transport; Transport Process; Travel; Walking; Woman; Work; absorption; abstracting; base; design; genetic regulatory protein; graduate student; innovation; insight; interest; lactose permease; meetings; melibiose permease; member; novel; novel strategies; novel therapeutics; planetary Atmosphere; posters; programs; public health relevance; sensor; social; success; sugar; symposium; voltage

DESCRIPTION (provided by applicant): We have planned a Gordon Research Conference that, true to the GRC's distinguished history and tradition, will foster productive and stimulating exchanges of ideas aimed at obtaining a mechanistic understanding of membrane transport processes and their regulation. The field of transporters and channels has seen extraordinary progress in recent years, which bodes well for the timing and likely impact of this meeting. High-resolution structures of membrane proteins have been obtained, spurring a strong interest in functional and mechanistic analyses of these and other transporters, and attracting a new crop of young researchers. The central aim of this conference is to illuminate transport mechanisms by integrating structural data and functional findings. This type of integration is a crucial step toward understanding not only the transporters' function but also their rage- lotion and the role of many of these proteins in disease. This meeting will provide an ideal opportunity for younger investigators to interact extensively with top established scientists in the field, a type of interaction that is difficult to achieve in other settings. The areas to be addressed in the presentations at the conference will include physiology, biochemistry, biophysics, and cell biology. One new subject to be introduced will bring a new transformative perspective to the field: a novel approach to identifying and quantitating intermediates in the transport process, which consists of analyzing kinetic and electrophysiological data using first-principles- based equations to yield the relative populations of the molecular conformational and substrate occupancy states that participate in all stages of transport. We will organize a highly innovative session focused on this approach, where we will discuss thermodynamics, kinetics, and conformational states during transport. The session will also address the use of computational methods to pursue the same questions as well as to provide detailed information about the transitions between conformational states. Our conference will highlight cutting-edge discoveries and will gather promising young scientists and many of the most successful investigators in the field today. Therefore, robust financial support is crucial to the success of this meeting, particularly for recruiting young investigators, including graduate students, postdoctoral fellows, and junior faculty members. The impact that a conference like this can have on their future professional lives cannot be overestimated. Given the key physiological roles of membrane transporters and channels in such processes as ion metabolism, in retinal absorption of nutrients, and signal modulation in neurons, many of the topics to be covered are crucial lee relevant in both the basic and medical realms. A better understanding of the underlying mechanisms of membrane transporters and channels is essential not only for the elucidation of the normal physiology of a host of vital molecules, but also for the development of new therapeutic agents and approaches to a wide variety of diseases, including hypertension, depression, hypothyroidism, malabsorption syndromes, and cystic fibrosis.

描述（由申请人提供）：我们计划举办一次戈登研究会议，秉承 GRC 的杰出历史和传统，将促进富有成效和激励性的会议 交流思想，旨在获得对膜运输过程及其调节的机械理解。近年来，运输商和渠道领域取得了非凡的进展，这对于本次会议的时机和可能产生的影响来说是个好兆头。膜蛋白的高分辨率结构已经获得，激发了人们对这些转运蛋白和其他转运蛋白的功能和机制分析的浓厚兴趣，并吸引了一批新的年轻研究人员。本次会议的中心目标是通过整合结构数据和功能发现来阐明运输机制。这种类型的整合是了解转运蛋白功能、了解它们的作用以及许多这些蛋白质在疾病中的作用的关键一步。这次会议将为年轻的研究人员提供一个与该领域顶尖科学家广泛互动的理想机会，这种互动在其他环境中很难实现。会议演讲涉及的领域将包括生理学、生物化学、生物物理学和细胞生物学。即将推出的一个新课题将为该领域带来新的变革视角：一种识别和定量运输过程中中间体的新方法，其中包括使用基于第一性原理的方程分析动力学和电生理学数据，以得出相对群体参与运输所有阶段的分子构象和底物占据状态。我们将组织一场高度创新的会议，重点关注这种方法，讨论运输过程中的热力学、动力学和构象状态。该会议还将讨论使用计算方法来解决相同的问题，并提供有关构象状态之间转变的详细信息。我们的会议将重点介绍前沿发现，并将聚集有前途的年轻科学家和当今该领域许多最成功的研究人员。因此，强有力的资金支持对于本次会议的成功至关重要，特别是招募年轻的研究人员，包括研究生、博士后和初级教师。像这样的会议对他们未来职业生涯的影响怎么估计都不为过。鉴于膜转运蛋白和通道在离子代谢、视网膜营养吸收和神经元信号调节等过程中的关键生理作用，要涵盖的许多主题在基础和医学领域都至关重要。更好地了解膜转运蛋白和通道的潜在机制不仅对于阐明许多重要分子的正常生理学至关重要，而且对于开发治疗包括高血压在内的多种疾病的新治疗药物和方法至关重要、抑郁症、甲状腺功能减退症、吸收不良综合征和囊性纤维化。