2011 Mechanisms of Membrane Transport Gordon Research Conference

2011年膜传输机制戈登研究会议

• 批准号: 8128181
• 负责人: Nancy Carrasco
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128181
• 关键词: Animal Model; Antidepressive Agents; Antihypertensive Agents; Area; Attention; Bartter Disease; Behavior; Beryllium; Biochemistry; Blood; Blood Circulation; Blood Pressure; Carrier Proteins; Cellular biology; Clinical; Collaborations; Computer Simulation; Cystic Fibrosis; Data; Development; Disease; Diuretics; Electrophysiology (science); Elements; Employee Strikes; Ensure; Excision; Faculty; Financial Support; Functional disorder; Funding; Future; Generations; Goals; Health; Human; Hypertension; Indium; Intestinal Absorption; Ion Channel; Ions; Kidney; Lead; Life; Link; Malabsorption Syndromes; Membrane; Membrane Proteins; Membrane Transport Proteins; Mission; Molecular; Molecular Genetics; Neurons; New England; Nutrient; Participant; Pharmaceutical Preparations; Physiological; Physiology; Play; Postdoctoral Fellow; Process; Proteins; Publishing; Pump; Recommendation; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Resolution; Role; Schedule; Science; Scientist; Seasons; Selection Criteria; Senior Scientist; Serum; Signal Transduction; Stretching; Structure; Techniques; Technology; Therapeutic Agents; Thinking; Time; Training; Transmembrane Transport; Transport Process; Travel; Universities; Walking; Water Movements; Work; abstracting; base; cohort; college; design; distraction; experience; gastrointestinal system; graduate student; improved; insight; meetings; member; multidisciplinary; novel; planetary Atmosphere; posters; programs; social; structural biology; success; symposium; uptake

DESCRIPTION (provided by applicant): Our objective is to organize and promote a Gordon Research Conference that will be a springboard for multidisciplinary discussion of ideas and technologies related to a mechanistic understanding of membrane transport processes and their regulation. This is a particularly opportune moment for such a meeting. Recent success in obtaining high-resolution structures of membrane proteins from model organisms has inspired the field and encouraged entry of a new generation of investigators. Though new structures continue to emerge at a rapid pace, functional analysis is having a rebirth in the context of these structures; mechanistic analyses guided by transporter structures are transforming our field. Mechanism encompasses both the detailed structure and the dynamic behavior of a transporter or channel; the broad and long term goal of the conference is to understand mechanism by tightly integrating insights from static structures with those from dynamic functional analyses. Understanding fundamental transporter mechanisms is a key step to understanding their physiological functions, their regulation, and their disruption in disease. Accordingly, the specific aims of "Mechanisms of membrane transport" GRC are to take advantage of the unprecedented opportunity to link form with function and encourage productive interactions between young investigators - largely trained in the physical and biophysical sciences - and more established investigators whose experience is in areas such as physiology, cell biology and biochemistry. Such dialogue occurs with difficulty in other settings, but is essential to the professional development of junior investigators and invigorates the portfolio of more senior scientists. This requires that our Conference emphasize the most relevant recent findings, and that we recruit promising young scientists as well as more seasoned investigators. This dual mission has been a guiding criterion in our selection of speakers and our organization of the program. Adequate financial support is essential and especially important for recruiting promising young investigators and ensuring adequate representation of postdoctoral fellows and graduate students. This cohort will soon be leading the field, and we must provide them sufficient financial support to attend a conference that will have a striking impact on their future. This work highly related to human health: transporters and channels are key elements in renal regulation of serum ion levels, intestinal absorption of nutrients, and neuronal modulation of signaling, among a host of other processes. Understanding the fundamental mechanisms of these proteins will lead to better understanding of normal function, of diseases like hypertension, malabsorption syndromes, and cystic fibrosis, and to development of new and improved therapeutic agents. PUBLIC HEALTH RELEVANCE: By regulating the movement of water soluble substrates such as ions and nutrients, transporters and channels play essential roles in both the kidney and digestive systems. Some transport proteins, called ion channels, exist primarily to send electrical signals by moving ions like K+, Ca2+, or Cl- across the membrane, whereas others, such as transporters and pumps, are involved in both signaling and nutrient access/removal. Transporters and channels act in concert as the core elements of the kidney's machinery to regulate serum ion concentrations, which in turn is essential for regulating blood's pressure and composition: dysfunction of key transporters and channels in the kidney leads directly to disorders of blood pressure, including Bartter's syndrome and other diseases. In the gut, transporters allow the selective uptake of nutrients into the bloodstream; dysfunction of these leads to malabsorption syndromes. Conversely, diseases can often be cured or controlled when transporter function is carefully modulated, as by a wide range of drugs in clinical use today (diuretics, antihypertensives, antidepressants and many others). To effectively understand and cure diseases of membrane transport function, we must understand how these transport proteins operate at the molecular level. Advancing this understanding is the goal of the "Mechanisms of Membrane Transport" Gordon Research Conference, which brings together some of the foremost scientists studying transport proteins to present and compare results, discuss new ideas, and establish collaborations.

描述（由申请人提供）：我们的目标是组织和促进戈登研究会议，该会议将是对与膜运输过程的机械理解及其调节有关的思想和技术进行多学科讨论的跳板。这是参加此次会议的特别时机。最近从模型生物获得膜蛋白的高分辨率结构方面的成功启发了该领域，并鼓励了新一代研究者的进入。尽管新结构继续以快速的速度出现，但功能分析在这些结构的背景下重生。运输蛋白结构指导的机械分析正在改变我们的领域。机制包括转运蛋白或通道的详细结构和动态行为；会议的广泛而长期的目标是通过将静态结构的见解与动态功能分析的分析紧密整合到理解机制。了解基本转运蛋白机制是了解其生理功能，调节和对疾病中断的关键步骤。因此，“膜运输机制” GRC的具体目的是利用前所未有的机会与功能联系起来，并鼓励年轻研究者之间的富有成效的互动 - 在物理和生物物理科学方面进行了很大的培训 - 以及更既定的研究人员，以及在生理学，生物学和生物学和生物学的领域中经验的研究人员。这种对话在其他环境中很难发生，但对于初级调查人员的专业发展至关重要，并使得更高级科学家的投资组合充满活力。这要求我们的会议强调最相关的发现，并且我们招募了有前途的年轻科学家以及更多经验丰富的研究人员。这项双重任务一直是我们选择的演讲者和我们的计划组织的指导标准。足够的财政支持至关重要，对于招募有前途的年轻调查员并确保充分代表博士后研究员和研究生而言尤其重要。该队列将很快领导该领域，我们必须为他们提供足够的财政支持，以参加将对他们的未来产生巨大影响的会议。这项工作与人类健康高度相关：转运蛋白和通道是血清离子水平，肠道吸收营养素的肾脏调节中的关键要素，以及信号传导的神经元调节。了解这些蛋白质的基本机制将使人们更好地了解正常功能，诸如高血压，吸收不良综合征和囊性纤维化以及新的和改善的治疗剂等疾病。 公共卫生相关性：通过调节离子和营养物质等水溶性底物的运动，转运蛋白和渠道在肾脏和消化系统中都起着重要作用。某些传输蛋白（称为离子通道）主要是为了通过移动K+，Ca2+或Cl-跨膜的离子发送电信号，而其他转运蛋白（例如转运蛋白和泵）参与了信号传导和养分访问/去除。转运蛋白和通道协同起作用，是调节血清离子浓度的肾脏机械的核心元素，这反过来又对调节血液的压力和成分至关重要：肾脏中关键转运蛋白和通道功能障碍直接导致血压疾病，包括Bartter的综合症和其他疾病。在肠道中，转运蛋白可以选择性地吸收养分进入血液。这些功能障碍导致吸收不良综合征。相反，当仔细调节转运蛋白功能时，通常可以治愈或控制疾病，例如当今临床用途的广泛药物（利尿剂，抗高素质剂，抗抑郁药和许多其他药物）。为了有效理解和治愈膜转运功能的疾病，我们必须了解这些转运蛋白如何在分子水平上运行。促进这种理解是“膜运输机制”戈登研究会议的目标，该会议汇集了一些研究运输蛋白的最重要的科学家，以提出和比较结果，讨论新思想并建立合作。