2011 Mechanisms of Membrane Transport Gordon Research Conference

2011年膜传输机制戈登研究会议

• 批准号: 8128181
• 负责人: Nancy Carrasco
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128181
• 关键词: Animal Model; Antidepressive Agents; Antihypertensive Agents; Area; Attention; Bartter Disease; Behavior; Beryllium; Biochemistry; Blood; Blood Circulation; Blood Pressure; Carrier Proteins; Cellular biology; Clinical; Collaborations; Computer Simulation; Cystic Fibrosis; Data; Development; Disease; Diuretics; Electrophysiology (science); Elements; Employee Strikes; Ensure; Excision; Faculty; Financial Support; Functional disorder; Funding; Future; Generations; Goals; Health; Human; Hypertension; Indium; Intestinal Absorption; Ion Channel; Ions; Kidney; Lead; Life; Link; Malabsorption Syndromes; Membrane; Membrane Proteins; Membrane Transport Proteins; Mission; Molecular; Molecular Genetics; Neurons; New England; Nutrient; Participant; Pharmaceutical Preparations; Physiological; Physiology; Play; Postdoctoral Fellow; Process; Proteins; Publishing; Pump; Recommendation; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Resolution; Role; Schedule; Science; Scientist; Seasons; Selection Criteria; Senior Scientist; Serum; Signal Transduction; Stretching; Structure; Techniques; Technology; Therapeutic Agents; Thinking; Time; Training; Transmembrane Transport; Transport Process; Travel; Universities; Walking; Water Movements; Work; abstracting; base; cohort; college; design; distraction; experience; gastrointestinal system; graduate student; improved; insight; meetings; member; multidisciplinary; novel; planetary Atmosphere; posters; programs; social; structural biology; success; symposium; uptake

DESCRIPTION (provided by applicant): Our objective is to organize and promote a Gordon Research Conference that will be a springboard for multidisciplinary discussion of ideas and technologies related to a mechanistic understanding of membrane transport processes and their regulation. This is a particularly opportune moment for such a meeting. Recent success in obtaining high-resolution structures of membrane proteins from model organisms has inspired the field and encouraged entry of a new generation of investigators. Though new structures continue to emerge at a rapid pace, functional analysis is having a rebirth in the context of these structures; mechanistic analyses guided by transporter structures are transforming our field. Mechanism encompasses both the detailed structure and the dynamic behavior of a transporter or channel; the broad and long term goal of the conference is to understand mechanism by tightly integrating insights from static structures with those from dynamic functional analyses. Understanding fundamental transporter mechanisms is a key step to understanding their physiological functions, their regulation, and their disruption in disease. Accordingly, the specific aims of "Mechanisms of membrane transport" GRC are to take advantage of the unprecedented opportunity to link form with function and encourage productive interactions between young investigators - largely trained in the physical and biophysical sciences - and more established investigators whose experience is in areas such as physiology, cell biology and biochemistry. Such dialogue occurs with difficulty in other settings, but is essential to the professional development of junior investigators and invigorates the portfolio of more senior scientists. This requires that our Conference emphasize the most relevant recent findings, and that we recruit promising young scientists as well as more seasoned investigators. This dual mission has been a guiding criterion in our selection of speakers and our organization of the program. Adequate financial support is essential and especially important for recruiting promising young investigators and ensuring adequate representation of postdoctoral fellows and graduate students. This cohort will soon be leading the field, and we must provide them sufficient financial support to attend a conference that will have a striking impact on their future. This work highly related to human health: transporters and channels are key elements in renal regulation of serum ion levels, intestinal absorption of nutrients, and neuronal modulation of signaling, among a host of other processes. Understanding the fundamental mechanisms of these proteins will lead to better understanding of normal function, of diseases like hypertension, malabsorption syndromes, and cystic fibrosis, and to development of new and improved therapeutic agents. PUBLIC HEALTH RELEVANCE: By regulating the movement of water soluble substrates such as ions and nutrients, transporters and channels play essential roles in both the kidney and digestive systems. Some transport proteins, called ion channels, exist primarily to send electrical signals by moving ions like K+, Ca2+, or Cl- across the membrane, whereas others, such as transporters and pumps, are involved in both signaling and nutrient access/removal. Transporters and channels act in concert as the core elements of the kidney's machinery to regulate serum ion concentrations, which in turn is essential for regulating blood's pressure and composition: dysfunction of key transporters and channels in the kidney leads directly to disorders of blood pressure, including Bartter's syndrome and other diseases. In the gut, transporters allow the selective uptake of nutrients into the bloodstream; dysfunction of these leads to malabsorption syndromes. Conversely, diseases can often be cured or controlled when transporter function is carefully modulated, as by a wide range of drugs in clinical use today (diuretics, antihypertensives, antidepressants and many others). To effectively understand and cure diseases of membrane transport function, we must understand how these transport proteins operate at the molecular level. Advancing this understanding is the goal of the "Mechanisms of Membrane Transport" Gordon Research Conference, which brings together some of the foremost scientists studying transport proteins to present and compare results, discuss new ideas, and establish collaborations.

描述（由申请人提供）：我们的目标是组织和推广戈登研究会议，该会议将成为多学科讨论与膜传输过程及其调节的机械理解相关的想法和技术的跳板。对于这样的会议来说，现在是一个特别合适的时机。最近从模式生物中获得高分辨率膜蛋白结构的成功启发了该领域并鼓励了新一代研究人员的进入。尽管新的结构不断快速出现，但功能分析正在这些结构的背景下重生。以转运体结构为指导的机械分析正在改变我们的领域。机制包括转运蛋白或通道的详细结构和动态行为；会议的广泛和长期目标是通过将静态结构的见解与动态功能分析的见解紧密结合来理解机制。了解基本转运蛋白机制是了解其生理功能、调节及其对疾病的破坏的关键一步。因此，“膜运输机制”GRC 的具体目标是利用前所未有的机会将形式与功能联系起来，并鼓励年轻研究人员（主要受过物理和生物物理科学培训）与经验丰富的资深研究人员之间进行富有成效的互动。在生理学、细胞生物学和生物化学等领域。这种对话在其他环境中很难进行，但对于初级研究人员的专业发展至关重要，并能激发更多资深科学家的活力。这要求我们的会议强调最相关的最新发现，并招募有前途的年轻科学家以及经验丰富的研究人员。这一双重使命一直是我们选择演讲者和组织活动的指导标准。充足的财政支持至关重要，对于招募有前途的年轻研究人员和确保博士后研究员和研究生的充分代表性尤其重要。这群人很快将成为该领域的领先者，我们必须为他们提供足够的财政支持，以参加一次将对他们的未来产生巨大影响的会议。这项工作与人类健康高度相关：转运蛋白和通道是肾脏调节血清离子水平、肠道营养吸收、神经元信号调节以及许多其他过程的关键要素。了解这些蛋白质的基本机制将有助于更好地了解高血压、吸收不良综合征和囊性纤维化等疾病的正常功能，并有助于开发新的和改进的治疗药物。 公共健康相关性：通过调节离子和营养物质等水溶性底物的运动，转运蛋白和通道在肾脏和消化系统中发挥着重要作用。一些转运蛋白（称为离子通道）主要通过跨膜移动 K+、Ca2+ 或 Cl- 等离子来发送电信号，而其他蛋白（例如转运蛋白和泵）则参与信号传导和营养物质的获取/去除。转运蛋白和通道协同作用，作为肾脏调节血清离子浓度的机制的核心要素，而血清离子浓度又对于调节血压和成分至关重要：肾脏中关键转运蛋白和通道的功能障碍直接导致血压紊乱，包括巴特综合症和其他疾病。在肠道中，转运蛋白允许选择性地将营养物质摄取到血液中；这些功能障碍会导致吸收不良综合征。相反，当转运蛋白功能得到仔细调节时，疾病通常可以得到治愈或控制，就像当今临床使用的各种药物（利尿剂、抗高血压药、抗抑郁药等）一样。为了有效地了解和治疗膜转运功能疾病，我们必须了解这些转运蛋白如何在分子水平上发挥作用。促进这种理解是“膜运输机制”戈登研究会议的目标，该会议汇集了一些研究运输蛋白的最顶尖的科学家，展示和比较结果，讨论新想法并建立合作。