Women's Cancer

女性癌症

• 批准号: 8530537
• 负责人: LEVI S. DOWNS
• 金额: $ 0.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8530537
• 关键词: Adjuvant Therapy; Aromatase; Biological Models; Biology; Breast; Breast Cancer Treatment; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Cessation of life; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Cytotoxic Chemotherapy; Detection; Disease; Doctor of Medicine; ERBB2 gene; Functional Imaging; Funding; Gene Amplification; Gene Expression; Gene Expression Profiling; Goals; Gynecologic; Home environment; Immunotherapy; Laboratory Finding; Link; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of ovary; Mentorship; Molecular; Outcome; Pathway interactions; Peer Review; Population; Postmenopause; Prediction of Response to Therapy; Prevention strategy; Production; Publications; Receptor Protein-Tyrosine Kinases; Recruitment Activity; Research; Research Personnel; Research Project Grants; Role; Schools; Screening procedure; Signal Transduction; Staging; Therapeutic; Translating; Translational Research; Woman; base; cancer diagnosis; cancer prevention; clinical practice; improved; innovation; interest; malignant breast neoplasm; member; mortality; programs; steroid hormone receptor; tool; vaccine development

8.6.1 ABSTRACT The Women's Cancer Program, led by Douglas Yee, M.D. and Levi Downs, M.D., has 32 members, representing 13 departments and four schools. As of September 30, 2007, these members have a total of $6.6 million in peer reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 281 publications, of which 18% were intra-programmatic and 17% were interprogrammatic. This program was created by combining the members of the Breast Cancer program with new members interested in gynecologic malignancies. By creating the Women's Cancer program, we strengthened existing collaborations, enhanced the interaction between members performing similarly themed research, provided additional scientific mentorship for clinical investigators, and enhanced our capacity for translational research. The scientific goals of the program are to improve detection and prevention strategies, study mechanisms basic to cancer biology, translate research findings into innovative clinical strategies. To achieve these goals, the program is organized into four research themes: 1) functional imaging for cancer diagnosis, staging, and prediction of response to therapy, 2) angiogensis in breast and ovarian cancer, 3) gene expression, cell signaling, and steroid hormone receptor biology, and 4) translational research in cancer prevention and treatmet.

8.6.1摘要 由M.D. Douglas Yee和M.D.的Levi Down领导的女性癌症计划，有32名成员， 代表13个部门和4所学校。截至2007年9月30日，这些成员总共有 660万美元的同行审查了当前预算期间的资助研究项目。自2003年6月以来 研究产生了281个出版物，其中18％是概括性的，有17％是解释性的。 该计划是通过将乳腺癌计划的成员与 对妇科恶性肿瘤感兴趣的新成员。通过创建女性癌症计划，我们 加强了现有的合作，增强了同样表现的成员之间的互动 主题研究，为临床研究人员提供了更多的科学指导，并增强了我们的 翻译研究的能力。该计划的科学目标是改善检测和 预防策略，癌症生物学基础的研究机制，将研究结果转化为创新 临床策略。为了实现这些目标，该计划被组织为四个研究主题：1） 癌症诊断，分期和对治疗反应的预测的功能成像，2）血管生成 乳腺癌和卵巢癌，3）基因表达，细胞信号传导和类固醇激素受体生物学，4） 癌症预防和治疗方法的转化研究。