PROTON RADIATION THERAPY RESEARCH

质子放射治疗研究

• 批准号: 8336792
• 负责人: THOMAS F DELANEY
• 金额: $ 265.39万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8336792
• 关键词: Address; Anatomy; Applications Grants; Cessation of life; Childhood Medulloblastomas; Childhood Rhabdomyosarcoma; Clinical; Clinical Treatment; Complication; Conduct Clinical Trials; Disease; Disorder by Site; Dose; Environment; Ethics; Failure; Functional disorder; Goals; Hemorrhage; Hospitals; Intensity-Modulated Radiotherapy; Internet; Laboratory Research; Lead; Liver neoplasms; Localized Disease; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Morbidity - disease rate; Motion; Neoplasm Metastasis; Non-Small-Cell Lung Carcinoma; Normal tissue morphology; Organ; Outcome; Pain; Paranasal Sinus Sarcoma; Patients; Photons; Physics; Probability; Proton Radiation; Protons; Public Health; Radiation; Radiation therapy; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Reading; Relative (related person); Reporting; Research; Risk; Roentgen Rays; Role; Safety; Site; Source; Staging; Structure; Symptoms; Techniques; Technology; Testing; Therapeutic; Therapeutic Studies; Time; Tissues; Tumor Tissue; Uncertainty; Vertebral column; acronyms; base; cancer therapy; clinical research site; experience; improved; injured; killings; meetings; operation; programs; proton beam; randomized trial; skull base; stem; tumor

Objectives and Specific Aims The goal of cancer treatment is cure without morbidity. Radiation can be an effective locoregional cancer treatment. While any tumor can be killed with enough radiation, any normal tissue can also be injured with sufficient dose to a given volume. The challenge is to deliver the appropriate dose to only those tissues containing tumor. Protons, with no exit dose beyond the target, irradiate less normal tissue than comparable photon (X-ray) fields. This can improve the therapeutic ratio of cure probability to complication risk. While many patients have been treated with protons with impressive clinical results in a number of disease sites, we believe that research can enable and enhance the use of protons in other disease sites. The objective of this multi-institutional program project is to apply advanced proton radiation planning and delivery techniques to improve outcome for patients with non-small cell lung cancer, liver tumors, pediatric medulloblastoma and rhabdomyosarcoma, spine/skull base sarcomas, and paranasal sinus malignancies. We hypothesize that through better use and understanding of the proton range in tissue, and study and management of motion and anatomic changes in the tumor and normal tissues, we can deliver higher precision proton therapy to further improve target coverage and/or reduce dose to nearby critical structures. To test this hypothesis, we propose four integrated projects: (1) Proton Dose Escalation and Proton vs. Photon Randomized Trials for the Treatment of Nonsmall Cell Lung Cancer, (2)lmproving the Therapeutic Ration of Proton Radiation Therapy in Challenging Clinical Sites, (3) Reducing Range Uncertainties in Proton Radiation Therapy, (4) Achieving What-You-See-ls-What-You-Get in Proton Radiation Therapy. The proton physical interactions sufficient to allow smallerspecific aims are to (1) develop an understanding of safety margins as well as more robust and conformal dose distributions, allowing protons to more nearly meet their full potential, and to verify that these advantages can be reliably achieved; (2) use these advantages in randomized clinical trials of protons vs. photons in lung cancer; and (3) to use these advantages in the proton therapy of a number of tumor sites for which protons are judged to have an increasingly important role and which have proven problematic for clinicians in the past.

目标和特定目标 癌症治疗的目的是治愈而没有发病率。辐射可以是有效的局部癌症治疗。虽然任何肿瘤可以用足够的辐射杀死，但任何正常的组织也可以通过足够剂量受伤至给定的体积。面临的挑战是将适当的剂量递送给只有那些含有肿瘤的组织。质子没有出口剂量以外的出口剂量，比可比的光子（X射线）磁场受照射的正常组织少。这可以提高治疗概率与并发症风险的治疗比率。 尽管许多患者在许多疾病部位都接受了具有令人印象深刻的临床结果的质子治疗，但我们认为研究可以在其他疾病部位实现并增强质子的使用。 这个多机构计划项目的目的是应用先进的质子辐射计划和输送技术，以改善非小细胞肺癌，肝肿瘤，小儿髓母细胞瘤和横纹细胞肉瘤，脊柱/颅骨底部肉瘤和帕拉纳萨鼻鼻窦恶性肿瘤的患者的预后。 我们假设，通过更好地利用和理解组织中质子范围，并研究和管理肿瘤和正常组织的运动和解剖学变化，我们可以提供更高的精度质子治疗，以进一步改善目标覆盖率和/或减少对附近关键结构的剂量。 To test this hypothesis, we propose four integrated projects: (1) Proton Dose Escalation and Proton vs. Photon Randomized Trials for the Treatment of Nonsmall Cell Lung Cancer, (2)lmproving the Therapeutic Ration of Proton Radiation Therapy in Challenging Clinical Sites, (3) Reducing Range Uncertainties in Proton Radiation Therapy, (4) Achieving What-You-See-ls-What-You-Get在质子辐射疗法中。质子的物理相互作用足以允许特定于特异性的目标是（1）对安全边缘以及更健壮和保形剂量分布的理解，使质子更加几乎可以完全满足其全部潜力，并验证这些优势可以可靠地实现； （2）在肺癌中质子与光子的随机临床试验中使用这些优势； （3）在许多肿瘤部位的质子疗法中使用这些优势，质子质子被认为具有越来越重要的作用，并且过去对临床医生的质疑是有问题的。