Does Dietary Antioxidant Predict Aggressiveness of Prostate Cancer?

膳食抗氧化剂是否可以预测前列腺癌的侵袭性？

• 批准号: 8244618
• 负责人: Ock K. Chun
• 金额: $ 8万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-14 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8244618
• 关键词: Accounting; African American; Age; Antioxidants; Behavior; Behavioral; Bioenergetics; Cancer Biology; Cancer Patient; Cessation of life; Chemicals; Data; Demographic Factors; Development; Diagnosis; Diet; Dietary intake; Epidemiologic Studies; Etiology; Failure; Family history of; Food; Health Services Accessibility; Human; Incidence; Intake; Intervention; Life Style; Louisiana; Malignant neoplasm of prostate; Mediating; Mitochondria; Newly Diagnosed; North Carolina; Nutritional; Outcome; Oxidation-Reduction; Oxidative Stress; Pathogenesis; Patients; Pilot Projects; Plasma; Preventive; Principal Investigator; Property; Race; Reactive Oxygen Species; Recruitment Activity; Risk; Role; Screening for Prostate Cancer; Source; Subgroup; Sum; Testing; Tissue Sample; Tissues; United States; Validation; Work; cancer diagnosis; cancer statistics; care seeking; caucasian American; dietary antioxidant; dietary supplements; in vivo; lifestyle factors; men; mortality; novel; oxidative damage; population based; prevent; programs; racial difference; tool; urinary

DESCRIPTION (provided by applicant): Considerable evidence suggests that oxidative stress contributes to the etiology, pathogenesis, and aggressiveness of prostate cancer (PCa). Consequently dietary antioxidants, which inactivate reactive oxygen species and provide protection from oxidative damage, are considered important preventive agents against the development of PCa. However, the association between antioxidants and PCa has not been demonstrated consistently across epidemiological studies that took into account both dietary and supplement intake. The inconsistencies may result in part from failure to account for major sources of antioxidants in human diets that derive from many different chemical forms and confound this association. Dietary total antioxidant capacity (TAC) is a new concept that enables one to estimate the sum of protective properties of dietary antioxidants against oxidative stress. Whether or not dietary TAC estimates correctly reflect in vivo antioxidant status and oxidative stress depends on the completeness and validity of dietary intake data that include accurate food composition data. Our recent studies indicate that dietary TAC levels of Caucasian Americans (CA) are higher than those of African Americans (AA). According to the U.S. Cancer Statistics for 2003-2007, the incidence rates of PCa are 50% higher for AA than CA, while mortality rates are 150% higher for AA. Factors proposed to explain this disparity include racial differences in PCa screening, access to care or care seeking behaviors, and etiologic and pathogenetic factors that influence PCa biology and aggressiveness. The racial disparity in PCa aggressiveness may be in part attributed to racial differences in antioxidant intake. However, limited information is available on the nutritional modulation of PCa aggressiveness. Thus, the objective of the proposed study is to determine the extent to which dietary TAC predicts PCa aggressiveness. The central hypothesis is that validation of a novel TAC tool will enable prediction of the risks of PCa mediated by oxidative stress. Our working hypothesis is that racial differences in PCa aggressiveness are in part the result of racial differences in antioxidant intake. To test the overall hypothesis, our specific aims are to: 1) determine the impact of dietary TAC on aggressiveness of newly diagnosed PCa; 2) determine whether dietary TAC level of PCa patients is associated with antioxidant-redox status in plasma, urinary, and PCa tissue samples; and 3) evaluate major dietary, sociodemographic, and lifestyle factors contributing to racial differences in dietary TAC of PCa patients by utilizing data on newl diagnosed PCa patients recruited through North Carolina-Louisiana Prostate Cancer Project. This project will provide important information on dietary TAC as a modifiable lifestyle factor among men diagnosed with PCa, and the extent to which it differs by race. Identification of dietary effects on PCa aggressiveness would suggest the importance of lifestyle behavioral factors in PCa outcome. Furthermore, the determination of racial differences in dietary behaviors may provide information that could be used to develop appropriate interventions to lower the risk of fatal PCa and reduce racial disparities in PCa mortality. PUBLIC HEALTH RELEVANCE: This pilot study aims to test the hypothesis that racial differences in prostate cancer aggressiveness are in part the result of racial differences in antioxidant intake by utilizing data of newly diagnosed prostate cancer patients recruited through the North Carolina-Louisiana Prostate Cancer Project. The findings from this study can be used to develop appropriate interventions to lower the risk of fatal prostate cancer and reduce racial disparities in prostate cancer mortality.

描述（由申请人提供）：大量证据表明，氧化应激有助于前列腺癌（PCA）的病因，发病机理和攻击性。因此，饮食中抗氧化剂灭活活性氧并提供氧化损伤的保护，被认为是重要的预防剂，以防止PCA的发展。但是，在饮食和补充摄入量都考虑到抗氧化剂与PCA之间的关联并未始终如一地证明。这些不一致可能部分是由于未能说明从许多不同化学形式而产生的人类饮食中的主要来源，并混淆了这种关联。饮食中总抗氧化剂能力（TAC）是一个新概念，可以估算饮食中抗氧化剂抗氧化应激的保护性能的总和。饮食TAC是否正确地反映了体内抗氧化剂状态 氧化应激取决于饮食摄入数据的完整性和有效性，包括精确的食物组成数据。我们最近的研究表明，饮食的TAC水平高加索美国人（CA）高于非裔美国人（AA）。根据2003 - 2007年美国癌症的统计数据，AA的PCA发病率比CA高50％，而AA的死亡率高150％。提议解释这种差异的因素包括PCA筛查的种族差异，获得护理或护理行为的访问以及影响PCA生物学和侵略性的病因和致病因素。 PCA侵略性的种族差异可能部分归因于抗氧化剂摄入量的种族差异。但是，有关PCA侵略性的营养调节的信息有限。因此，拟议的研究的目的是确定饮食TAC预测PCA侵略性的程度。中心假设是，新型TAC工具的验证将使氧化应激介导的PCA风险预测。我们的工作假设是，PCA侵略性的种族差异部分是抗氧化剂摄入种族差异的结果。为了检验总体假设，我们的具体目的是：1）确定饮食TAC对新诊断的PCA侵略性的影响； 2）确定PCA患者的饮食TAC水平是否与血浆，尿和PCA组织样品中的抗氧化剂 - 雷克斯状态有关； 3）评估主要的饮食，社会人口统计学和生活方式因素，从而通过利用通过北卡罗来纳州路易斯安那州北卡罗来纳州前列腺癌项目招募的NEWL诊断的PCA患者的数据来促进PCA患者饮食中的种族差异。该项目将提供有关饮食TAC的重要信息，作为被诊断为PCA的男性的可修改生活方式因素，以及种族有所不同的程度。识别饮食对PCA侵略性的影响将表明生活方式因素在PCA结果中的重要性。此外，饮食行为的种族差异的确定可能会提供可用于制定适当干预措施的信息，以降低致命PCA的风险并降低PCA死亡率的种族差异。 公共卫生相关性：这项试点研究旨在检验以下假设：前列腺癌侵略性的种族差异是通过利用北卡罗来纳州 - 路易斯安那州前列腺癌项目招募的新诊断的前列腺癌患者的抗氧化剂摄入量的种族差异。这项研究的发现可用于制定适当的干预措施，以降低致命前列腺癌的风险并降低前列腺癌死亡率中的种族差异。