Does Dietary Antioxidant Predict Aggressiveness of Prostate Cancer?

膳食抗氧化剂是否可以预测前列腺癌的侵袭性？

• 批准号: 8443794
• 负责人: Ock K. Chun
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-14 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8443794
• 关键词: Accounting; African American; Age; Antioxidants; Behavior; Behavioral; Bioenergetics; Cancer Biology; Cancer Patient; Cessation of life; Chemicals; Data; Demographic Factors; Development; Diagnosis; Diet; Dietary intake; Epidemiologic Studies; Etiology; Failure; Family history of; Food; Health Services Accessibility; Human; Incidence; Intake; Intervention; Life Style; Louisiana; Malignant neoplasm of prostate; Mediating; Mitochondria; Newly Diagnosed; North Carolina; Nutritional; Outcome; Oxidation-Reduction; Oxidative Stress; Pathogenesis; Patients; Pilot Projects; Plasma; Preventive; Principal Investigator; Property; Race; Reactive Oxygen Species; Recruitment Activity; Risk; Role; Screening for Prostate Cancer; Source; Subgroup; Sum; Testing; Tissue Sample; Tissues; United States; Validation; Work; cancer diagnosis; cancer statistics; care seeking; caucasian American; dietary antioxidant; dietary supplements; in vivo; lifestyle factors; men; mortality; novel; oxidative damage; population based; prevent; programs; racial difference; tool; urinary

DESCRIPTION (provided by applicant): Considerable evidence suggests that oxidative stress contributes to the etiology, pathogenesis, and aggressiveness of prostate cancer (PCa). Consequently dietary antioxidants, which inactivate reactive oxygen species and provide protection from oxidative damage, are considered important preventive agents against the development of PCa. However, the association between antioxidants and PCa has not been demonstrated consistently across epidemiological studies that took into account both dietary and supplement intake. The inconsistencies may result in part from failure to account for major sources of antioxidants in human diets that derive from many different chemical forms and confound this association. Dietary total antioxidant capacity (TAC) is a new concept that enables one to estimate the sum of protective properties of dietary antioxidants against oxidative stress. Whether or not dietary TAC estimates correctly reflect in vivo antioxidant status and oxidative stress depends on the completeness and validity of dietary intake data that include accurate food composition data. Our recent studies indicate that dietary TAC levels of Caucasian Americans (CA) are higher than those of African Americans (AA). According to the U.S. Cancer Statistics for 2003-2007, the incidence rates of PCa are 50% higher for AA than CA, while mortality rates are 150% higher for AA. Factors proposed to explain this disparity include racial differences in PCa screening, access to care or care seeking behaviors, and etiologic and pathogenetic factors that influence PCa biology and aggressiveness. The racial disparity in PCa aggressiveness may be in part attributed to racial differences in antioxidant intake. However, limited information is available on the nutritional modulation of PCa aggressiveness. Thus, the objective of the proposed study is to determine the extent to which dietary TAC predicts PCa aggressiveness. The central hypothesis is that validation of a novel TAC tool will enable prediction of the risks of PCa mediated by oxidative stress. Our working hypothesis is that racial differences in PCa aggressiveness are in part the result of racial differences in antioxidant intake. To test the overall hypothesis, our specific aims are to: 1) determine the impact of dietary TAC on aggressiveness of newly diagnosed PCa; 2) determine whether dietary TAC level of PCa patients is associated with antioxidant-redox status in plasma, urinary, and PCa tissue samples; and 3) evaluate major dietary, sociodemographic, and lifestyle factors contributing to racial differences in dietary TAC of PCa patients by utilizing data on newl diagnosed PCa patients recruited through North Carolina-Louisiana Prostate Cancer Project. This project will provide important information on dietary TAC as a modifiable lifestyle factor among men diagnosed with PCa, and the extent to which it differs by race. Identification of dietary effects on PCa aggressiveness would suggest the importance of lifestyle behavioral factors in PCa outcome. Furthermore, the determination of racial differences in dietary behaviors may provide information that could be used to develop appropriate interventions to lower the risk of fatal PCa and reduce racial disparities in PCa mortality.

描述（由申请人提供）：大量证据表明氧化应激有助于前列腺癌（PCa）的病因、发病机制和侵袭性。因此，膳食抗氧化剂可以灭活活性氧并提供免受氧化损伤的保护，被认为是预防 PCa 发展的重要预防剂。然而，在考虑膳食和补充剂摄入量的流行病学研究中，抗氧化剂和 PCa 之间的关联尚未得到一致证明。这种不一致的部分原因可能是未能解释人类饮食中抗氧化剂的主要来源，这些抗氧化剂来自许多不同的化学形式，并混淆了这种关联。膳食总抗氧化能力（TAC）是一个新概念，使人们能够估计膳食抗氧化剂对抗氧化应激的保护特性的总和。饮食 TAC 估算是否正确反映体内抗氧化状态 氧化应激取决于膳食摄入数据的完整性和有效性，其中包括准确的食物成分数据。我们最近的研究表明，白种美国人 (CA) 的膳食 TAC 水平高于非裔美国人 (AA)。根据2003-2007年美国癌症统计，AA的PCa发病率比CA高50%，而AA的死亡率高150%。解释这种差异的因素包括 PCa 筛查的种族差异、获得护理或寻求护理行为的差异，以及影响 PCa 生物学和攻击性的病因和发病因素。 PCa 侵袭性的种族差异可能部分归因于抗氧化剂摄入量的种族差异。然而，关于前列腺癌侵袭性的营养调节的信息有限。因此，本研究的目的是确定膳食 TAC 在多大程度上预测 PCa 侵袭性。中心假设是，验证一种新型 TAC 工具将能够预测氧化应激介导的 PCa 风险。我们的工作假设是前列腺癌攻击性的种族差异部分是由于抗氧化剂摄入量的种族差异造成的。为了检验总体假设，我们的具体目标是：1）确定饮食 TAC 对新诊断 PCa 侵袭性的影响； 2) 确定PCa患者的饮食TAC水平是否与血浆、尿液和PCa组织样本中的抗氧化氧化还原状态相关； 3) 利用北卡罗来纳州-路易斯安那州前列腺癌项目招募的新诊断 PCa 患者的数据，评估导致 PCa 患者饮食 TAC 种族差异的主要饮食、社会人口统计学和生活方式因素。该项目将提供关于饮食 TAC 作为诊断患有 PCa 的男性中可改变的生活方式因素的重要信息，以及不同种族之间的差异程度。饮食对 PCa 侵袭性影响的识别表明生活方式行为因素在 PCa 结果中的重要性。此外，确定饮食行为的种族差异可以提供可用于制定适当干预措施的信息，以降低致命性前列腺癌的风险并减少前列腺癌死亡率的种族差异。

项目成果

Dietary antioxidants and prostate cancer: a review.

• DOI: 10.1080/01635581.2013.806672
• 发表时间: 2013
• 期刊: Nutrition and cancer
• 作者: Vance TM;Su J;Fontham ET;Koo SI;Chun OK
• 通讯作者: Chun OK

Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study.

在一项基于人群的研究中，膳食总抗氧化能力与前列腺癌的侵袭性呈负相关。

• DOI: 10.1080/01635581.2016.1134596
• 发表时间: 2016
• 期刊: Nutrition and cancer
• 作者: Vance,TerrenceM;Wang,Ying;Su,LJoseph;Fontham,ElizabethTH;Steck,SusanE;Arab,Lenore;Bensen,JeannetteT;Mohler,JamesL;Chen,Ming-Hui;Chun,OckK
• 通讯作者: Chun,OckK

Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants.

• DOI: 10.1155/2015/728046
• 发表时间: 2015
• 期刊: Prostate cancer
• 影响因子: 4.2
• 作者: Vance TM;Azabdaftari G;Pop EA;Lee SG;Su LJ;Fontham ET;Bensen JT;Steck SE;Arab L;Mohler JL;Chen MH;Koo SI;Chun OK
• 通讯作者: Chun OK