CELL IMAGING AND MICROSCOPY SHARED RESOURCE

细胞成像和显微镜共享资源

• 批准号: 8512138
• 负责人: Adam I. Marcus
• 金额: $ 7.83万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512138
• 关键词: Animals; Archives; Biological Markers; Budgets; Calendar; Cancer Center Support Grant; Cells; Cellular biology; Clinical; Collaborations; Collection; Consultations; Data; Data Analyses; Development; Diagnostic; Drug Delivery Systems; Employee; Ensure; Fees; Grant; Hour; Housing; Human Resources; Image; Image Analysis; Imaging technology; Institutes; Instruction; Life; Malignant Neoplasms; Microscopy; Mission; Molecular; Nanotechnology; Pharmacology; Publications; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Scanning; Science; Secure; Services; Technology; Training; User Compliance; anticancer research; assay development; cancer cell; cellular imaging; fluorescence imaging; image processing; member; new technology; operation; tumor

PROJECT SUMMARY (See instructions): The Cell Imaging and Microscopy Shared Resource (CIM) provides cellular imaging technologies and services to enhance the programmatic research objectives of the Winship Cancer Institute (Winship). It is centrally located in Winship and houses state-of-the-art technologies including point scanning confocal, live cell confocal, spectral confocal imaging, epifluorescence microscopy, and image processing and analysis. CIM services have supported numerous Winship programmatic initiatives that include cancer cell biology, biomarker development, cancer nanotechnology, tumor diagnostics, drug delivery, and molecular pharmacology. These interactions have resulted in high Impact publications, team science grants, and inter- and intra-programmatic collaborations. Winship members comprise 88% of total CIM usage, with overall usage increasing from 1533 hours in calendar year 2008 to 4332 hours in 2010. CIM personnel provide consultation on experimental setup, execution, and analysis to ensure optimal image acquisition and data analysis. This includes comprehensive training sessions and dally user assistance to ensure that technologies are properly utilized. Alt user image data are archived nightly onto NAS enterprise level RAID protected servers to provide secure data backup. The CIM is a Winship shared resource, and Winship is responsible for oversight, operations, budget, compliance, user fee collection, and employee relations. The CIM Director makes all day-to-day decisions with input from CIM personnel, users, an internal advisory board, and executive oversight committee. The primary objectives of the CIM over the next two years are to expand small animal fluorescence imaging resources, implement a new assay development service, and continue to expand our IT infrastructure. These new technologies along with existing CIM services will enhance Winship's basic, translational, and clinical initiatives of Winship.

项目摘要（请参阅说明）： 细胞成像和显微镜共享资源（CIM）提供了细胞成像技术和服务，以增强Winship Cancer Institute（Winship）的程序化研究目标。它位于Winship中心，并拥有最先进的技术，包括点扫描共聚焦，活细胞共聚焦，光谱共聚焦成像，落叶显微镜以及图像处理和分析。 CIM服务支持包括癌细胞生物学，生物标志物开发，癌症纳米技术，肿瘤诊断，药物输送和分子药理学在内的众多Winship计划计划。这些相互作用导致了高影响力出版物，团队科学补助金以及跨编程内的合作。 Winship成员占CIM总使用量的88％，总体使用率从2008年日历年的1533小时增加到2010年的4332小时。CIM人员提供了有关实验设置，执行和分析的咨询，以确保最佳的图像习得和数据分析。这包括全面的培训课程和Dally用户帮助，以确保正确利用技术。 Alt用户图像数据在NAS Enterprise级别RAID受保护的服务器上归档，以提供安全的数据备份。 CIM是胜利船共享资源，Winship负责监督，运营，预算，合规，收费和员工关系。 CIM主任通过CIM人员，用户，内部顾问委员会和执行监督委员会的意见做出全天决定。在接下来的两年中，CIM的主要目标是扩大小型动物荧光成像资源，实施新的测定开发服务，并继续扩大我们的IT基础设施。这些新技术以及现有的CIM服务将增强Winship的Winship的基本，翻译和临床计划。