Validation of chair-side biochemical screening instruments for dental caries

椅旁龋齿生化筛查仪器的验证

基本信息

批准号：
8298166
负责人：
EVANGELIA MOROU-BERMUDEZ
金额：
$ 15万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-08 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8298166
关键词：
Acids Address Adopted Adult Affect Age Alkalies Area Behavioral Biochemical Biological Biological Process Biology Caries prevention Child Child Support Clinical Clinical Research Communities Cross-Sectional Studies Data Dental Dental General Practice Dental Plaque Dental Technology Dental caries Dentists Detection Development Disease Effectiveness Figs - dietary Foundations Future Generations Goals Gold Health Health Professional Individual Infant Intervention Knowledge Lesion Measures Methodology Methods Modeling Onset of illness Patients Population Population Study Prevalence Preventive Problem Solving Procedures Production Prospective Studies Public Health Quality of life Regression Analysis Research Research Design Risk Risk Assessment Risk Factors Saliva Salivary Sampling School Nursing Screening procedure Side Source Streptococcus mutans Sugar Acids Test Result Testing United States Urea Validation Validity and Reliability Visual Work age group base community intervention cost early childhood ethnic minority population experience health disparity high risk innovation instrument low socioeconomic status meetings novel novel strategies pediatrician post intervention psychosocial research study socioeconomics success tool

项目摘要

DESCRIPTION (provided by applicant): The need to develop an accurate chair-side screening instrument for caries activity and caries risk has been long recognized and extensive research work has been done in this area without much success. Our study takes a new approach in solving this problem. This approach is founded on a novel model, the Caries Risk Pyramid (CRP), which summarizes the available knowledge regarding the biology of dental caries. HYPOTHESIS: Based on the CRP model, we hypothesize that measuring the ability of dental plaque and/or saliva to generate alkali from urea, or other salivary substrates, together with the ability to generate acid from sugars, can provide an accurate estimation of an individual's caries status and possibly future caries risk because they summarize the combined effect of other caries risk factors. OBJECTIVE: In order to test this hypothesis we have developed an array of novel, chair-side tests for measuring acid and alkali generation in plaque and in saliva. The objective of this study is to assess the reliability and validity of these tests as screening tools for dental caries and to explore possible ways of combining the results of these tests in order to accurately identify individuals with caries. To accomplish this objective, a cross-sectional study on 200 adult subjects is proposed. SIGNIFICANCE: The proposed tests are novel because they consider the ability to generate alkali in plaque as a potential caries risk factor, which has not been previously included in existing multivariate risk assessment models. They are of low cost and give faster results compared to available biological caries risk tests. They do not require dental expertise, which makes them suitable for use by non-dental professionals. Once the tests have been validated in adults, our ultimate goal is to validate them in children and infants as screening tools for Early Childhood Caries (ECC), and ultimately as a predictor of future caries risk, either independently, or in combination with other caries risk factors. Another important potential application for the proposed tests would be the comparison of pre- to post- intervention risk in clinical dental practice, in research, and in community interventions.

描述（由申请人提供）：人们很早就认识到需要开发一种准确的椅旁筛查仪器来检测龋齿活动和龋齿风险，并且在该领域进行了广泛的研究工作，但没有取得太大成功。我们的研究采用了一种新方法来解决这个问题。这种方法建立在一种新颖的模型之上，即龋齿风险金字塔（CRP），该模型总结了有关龋齿生物学的现有知识。假设：基于 CRP 模型，我们假设测量牙菌斑和/或唾液从尿素或其他唾液底物产生碱的能力，以及从糖产生酸的能力，可以准确估计个体的龋齿状况和未来可能的龋齿风险，因为它们总结了其他龋齿风险因素的综合影响。目的：为了检验这一假设，我们开发了一系列新颖的椅旁测试，用于测量牙菌斑和唾液中酸和碱的生成。本研究的目的是评估这些测试作为龋齿筛查工具的可靠性和有效性，并探索结合这些测试结果的可能方法，以准确识别患有龋齿的个体。为了实现这一目标，建议对 200 名成人受试者进行横断面研究。意义：所提出的测试是新颖的，因为它们将牙菌斑中产生碱的能力视为潜在的龋齿风险因素，而该因素以前并未包含在现有的多变量风险评估模型中。与现有的生物龋齿风险测试相比，它们成本低廉，并且给出更快的结果。它们不需要牙科专业知识，这使得它们适合非牙科专业人员使用。一旦这些测试在成人中得到验证，我们的最终目标是在儿童和婴儿中验证它们作为早期儿童龋齿 (ECC) 的筛查工具，并最终作为未来龋齿风险的预测因子，无论是独立的还是与其他龋齿结合的风险因素。所提出的测试的另一个重要的潜在应用是比较临床牙科实践、研究和社区干预中干预前和干预后的风险。