Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries

氟化碘清漆预防龋齿的科学依据

• 批准号: 8519157
• 负责人: Peter M Milgrom
• 金额: $ 11.72万
• 依托单位: ADP SILVER DENTAL ARREST, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519157
• 关键词: Acids; Adolescent; Adult; Age; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Biological; Biological Availability; Businesses; Carbohydrates; Caries prevention; Characteristics; Child; Childhood; Chronic; Chronic Disease; Collaborations; Data; Dental; Dental Enamel; Dental Plaque; Dental caries; Diet; Disease; Effectiveness; Esthetics; FDA approved; Fluoride Varnishes; Fluorides; Fostering; Glycolysis Inhibition; Grant; Human; In Vitro; Iodine; Kinetics; Laboratories; Local Anti-Infective Agents; Marketing; Modeling; Modification; Oral; Oral health; Pain; Pharmacologic Substance; Phase; Population; Povidone-Iodine; Prevalence; Property; Reporting; Research; Research Personnel; Silver; Small Business Innovation Research Grant; Sodium Fluoride; Streptococcus mutans; Surgeon; Systemic infection; Testing; Tooth structure; Topical Fluorides; Universities; Varnish; Virulence Factors; Washington; Xerostomia; antimicrobial; bactericide; base; cariogenic bacteria; cost; ethnic disadvantage; ethnic minority population; experience; health disparity; high risk; in vitro Model; in vivo; oral bacteria; pathogen; prevent; public health relevance; remineralization

DESCRIPTION (provided by applicant): Topical fluorides have been the mainstay in the prevention of dental caries for decades. However, topical fluoride alone is not enough to thwart tooth decay in high-risk populations. The purpose of this Phase I application is to determine the technical and scientific feasibility of using a combination povidone-iodine (PVP-I)-5% sodium fluoride (NaF) varnish as a potential commercial product to prevent dental caries. The research will be conducted by the small business firm ADP Silver Dental Arrest, LLC, in collaboration with experienced researchers at the University of Washington Northwest Center to Reduce Oral Health Disparities. The Premier Dental Products Company will prepare the varnish to the specifications of the applicant at no cost to the grant. The Specific Aims of this Phase I SBIR are to: (1) Demonstrate that a new povidone iodine-sodium fluoride varnish has antimicrobial activity and fluoride bioavailability and enamel remineralization ability. (a) Use the in vitro moel developed by Castillo and colleagues to determine the bioavailability of fluoride and iodine release from an experimental povidone-iodine- sodium fluoride varnish; (b) Use an in vitro model of Tanzer and colleagues to assess the additive (indifferent), potentially synergistic, or potentially antagonistic effects of sodium fluoride and povidone-iodine against Streptococcus mutans using the criteria of Eliopoulos and Moellering; (c) Use a slight modification the Featherstone laboratory pH cycling model to test remineralization. (2) Assess the esthetic and organoleptic properties of the new povidone iodine-sodium fluoride varnish. Caries researchers for sometime have suggested strategies that combine an antiseptic with topical fluoride to reduce or eliminate the oral cariogenic bacteria reservoir in addition to topical fluoride which primarily remineralizes teeth enamel. Povidone-iodine is an FDA-approved and widely used bactericidal antiseptic. For the oral flora, iodine has preferential activities against streptococcl species. Moreover, iodine's effectiveness may last as long as six months.

描述（由申请人提供）：数十年来，局部氟化物一直是预防龋齿的主要手段。然而，仅局部使用氟化物不足以阻止高危人群的蛀牙。第一阶段申请的目的是确定使用聚维酮碘 (PVP-I)-5% 氟化钠 (NaF) 清漆组合作为预防龋齿的潜在商业产品的技术和科学可行性。该研究将由小型企业公司 ADP Silver Dental Arrest, LLC 与华盛顿大学西北减少口腔健康差异中心经验丰富的研究人员合作进行。 Premier Dental Products Company 将按照申请人的规格准备清漆，无需支付任何费用。 第一阶段SBIR的具体目标是：（1）证明新型聚维酮碘-氟化钠清漆具有抗菌活性、氟化物生物利用度和牙釉质再矿化能力。 (a) 使用 Castillo 及其同事开发的体外模型来确定实验性聚维酮-碘-氟化钠清漆中氟化物和碘释放的生物利用度； (b) 使用 Tanzer 及其同事的体外模型，按照 Eliopoulos 和 Moellering 的标准，评估氟化钠和聚维酮碘对变形链球菌的加和（无关）、潜在协同或潜在拮抗作用； (c) 使用稍微修改的 Featherstone 实验室 pH 循环模型来测试再矿化。 (2) 评估新型聚维酮碘氟化钠清漆的美学和感官特性。龋齿研究人员有时提出了一些策略，除了主要使牙釉质再矿化的局部氟化物之外，还结合使用防腐剂和局部氟化物来减少或消除口腔致龋细菌库。聚维酮碘是一种经 FDA 批准且广泛使用的杀菌防腐剂。对于口腔菌群，碘对链球菌属具有优先活性。此外，碘的有效性可持续长达六个月。