Training in isotopic techniques for metabolic research

代谢研究同位素技术培训

• 批准号: 8214577
• 负责人: Henri Brunengraber
• 金额: $ 10.8万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8214577
• 关键词: Advisory Committees; Animals; Bioinformatics; Development; Educational Activities; Educational process of instructing; Educational workshop; Faculty; Goals; Hand; Human; Investigation; Isotopes; Laboratories; Metabolic; Metabolism; Mus; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Phenotype; Proteomics; Research; Research Activity; Research Personnel; Running; Scientist; Series; Techniques; Technology; Testing; Texas; Time; Training; Training Activity; United States; United States National Institutes of Health; Universities; Washington; graduate student; literacy; medical schools; member; metabolic abnormality assessment; metabolomics

DESCRIPTION (provided by applicant): This application is presented on behalf of the Mouse Metabolic and Phenotyping Center (MMPC) network () and its Advisory Committee. The MMPC network groups five Centers (located at Case Western Reserve University, University of Cincinnati, University of Texas SouthWestern, University of Washington, Vanderbilt University, Yale University) and a Coordinating and Bioinformatics Unit (located at the Medical College of Georgia). The goal of this five-year project is to expand the educational and training activities of the MMPC network by organizing a series of courses and hand-on workshops on the use of isotopic techniques for metabolic investigations. Although the MMPC network was created to provide phenotyping testing in mice, it is integrated in the wider research and training activities of NIDDK, NHLBI and the NIH. Therefore, the scope of the planned courses and workshops on isotope technology will not be limited to investigations of mouse metabolism. The faculty who will run the courses and workshops have wide expertise in the use of isotopes for metabolic studies in animals and humans. They are also involved in the development of new isotopic, metabolomic and proteomic techniques which will allow major expansion of metabolic investigations conducted from the mouse to the bedside. This project builds on the teaching and training expertise of Dr Robert R. Wolfe, a member of the MMPC External Advisory Committee. Dr Wolfe has created in 1992, and taught eight times with colleagues, a course on the use of isotopes for metabolic studies. This course drew trainees from all over the United States. In October 2007, Dr Wolfe and MMPC faculty joined forces to teach a new version of the isotope course. This new course, which was very well received by about 80 trainees, is the template for the courses to be taught under the present application. In addition, we plan to conduct each year one specialized hand-on workshop in the laboratory of a member of the course faculty.

描述（由申请人提供）： 本申请代表小鼠代谢和表型中心 (MMPC) 网络 () 及其咨询委员会提交。 MMPC 网络由五个中心（位于凯斯西储大学、辛辛那提大学、德克萨斯大学西南大学、华盛顿大学、范德比尔特大学、耶鲁大学）和一个协调和生物信息学单位（位于佐治亚医学院）组成。 这个为期五年的项目的目标是通过组织一系列关于使用同位素技术进行代谢研究的课程和实践研讨会，扩大 MMPC 网络的教育和培训活动。尽管 MMPC 网络的创建是为了在小鼠中提供表型测试，但它已融入 NIDDK、NHLBI 和 NIH 更广泛的研究和培训活动中。因此，计划的同位素技术课程和研讨会的范围将不仅限于小鼠新陈代谢的研究。举办这些课程和研讨会的教师在使用同位素进行动物和人类代谢研究方面拥有广泛的专业知识。他们还参与新同位素、代谢组学和蛋白质组学技术的开发，这些技术将使代谢研究从小鼠到床边进行重大扩展。 该项目以 MMPC 外部咨询委员会成员 Robert R. Wolfe 博士的教学和培训专业知识为基础。 Wolfe 博士于 1992 年创建了一门关于使用同位素进行代谢研究的课程，并与同事一起讲授了八次。该课程吸引了来自美国各地的学员。 2007 年 10 月，Wolfe 博士和 MMPC 教师联手教授新版本的同位素课程。这门新课程受到约 80 名学员的好评，是本申请中教授的课程的模板。此外，我们计划每年在课程教员的实验室中举办一次专门的实践研讨会。