Recruiting and Retaining Young Adults in Behavioral Weight Loss Treatment

招募和留住年轻人进行行为减肥治疗

• 批准号: 8514771
• 负责人: Jessica Gokee LaRose
• 金额: $ 10.63万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-05 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514771
• 关键词: Address; Age; Behavioral; Body Weight decreased; Clinic; Clinical; Data; Data Analyses; Enrollment; Environment; Focus Groups; Goals; Health; Hospitals; Individual; Intervention; Knowledge; Maintenance; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Newsletter; Obesity; Overweight; Participant; Phase; Public Health; Qualitative Research; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Research Ethics; Research Methodology; Research Personnel; Research Training; Resources; Risk Factors; Sampling; Schedule; Testing; Training; United States; Weight Gain; Weight maintenance regimen; Wing; Woman; Work; age group; arm; base; career; design; experience; high risk; improved; medical schools; men; novel marker; pandemic disease; patient oriented research; programs; skills; young adult

DESCRIPTION (provided by applicant): The goal of this Mentored Patient-Oriented Research Career Award (K23) is to allow Dr. Gokee-LaRose to become an independent investigator focused on developing interventions to target modifiable CVD risk factors during the transition into young adulthood. This training plan, through didactic and direct mentored training experiences, will allow her to develop skills and expertise in: 1) design and conduct of randomized clinical trials (with an emphasis on obesity); 2) qualitative research methods, which will enable her to effectively tailor programs for young adults; 3) increased knowledge of CVD risk factors with relevance to young adults and methodology used to assess novel markers in RCTs; and 4) research ethics and the advanced statistical skills needed to analyze data resulting from RCTs. The resources at the Miriam Hospital/ Brown Medical School and close contact with her expert mentor team (Drs. Wing, Jelalian, Morrow, Lewis and Fava) will provide her with the ideal environment to achieve her training and research goals. Young adults between 18 and 25 are at particularly high risk for weight gain and obesity; yet, they are under-represented in standard programs and little is known about how best to recruit and/or retain this group in treatment. Our pilot data indicates significant weight losses can be achieved through a brief, clinic-based program with young adults, and maintained in the short-term. The goal of this proposal is twofold: 1) to conduct formative work aimed at improving recruitment and retention efforts with this age group, and 2) to conduct a randomized clinical trial to test the feasibility and preliminary efficacy of three different approaches to longer-term weight control. In Phase 1, 80 overweight or obese men and women ages 18-25 will participate in focus groups to address recruitment, retention and barriers to treatment. In Phase 2, a new sample of 90 participants will be enrolled in a brief, 10-week BWL program and then randomized to one of three maintenance arms through 12 months. Contact schedule and delivery format will be determined in part by Phase 1; the three arms will be continued face-to-face, a newsletter control, or an alternative form of continued contact. Assessments will take place at baseline, 10 weeks, 6 and 12 months. PUBLIC HEALTH RELEVANCE: Obesity has reached pandemic proportions in the United States, and young adults between 18 and 25 are at particularly high risk; yet to date, standard behavioral weight loss programs have not been successful at reaching this high-risk group. It remains unclear how best to recruit these individuals for treatment initially, or how to retain them in treatment in the longer-term. The proposed research fills this gap, and therefore stands to have substantial clinical and public health implications.

描述（由申请人提供）： 这项以患者为导向的研究职业奖 (K23) 的目标是让 Gokee-LaRose 博士成为一名独立研究者，专注于制定干预措施，以在向青年期过渡期间针对可改变的 CVD 风险因素。该培训计划通过教学和直接指导的培训经验，将使她能够发展以下方面的技能和专业知识：1）设计和进行随机临床试验（重点是肥胖）； 2）定性研究方法，这将使她能够有效地为年轻人量身定制计划； 3) 增加对与年轻人相关的CVD危险因素的了解以及用于评估随机对照试验中新标志物的方法； 4) 研究伦理和分析随机对照试验数据所需的高级统计技能。 Miriam 医院/布朗医学院的资源以及与她的专家导师团队（Drs. Wing、Jelalian、Morrow、Lewis 和 Fava）的密切联系将为她提供实现培训和研究目标的理想环境。 18 至 25 岁之间的年轻人体重增加和肥胖的风险特别高；然而，他们在标准计划中的代表性不足，而且对于如何最好地招募和/或保留这一群体接受治疗知之甚少。我们的试点数据表明，通过针对年轻人的简短的、基于临床的计划可以实现显着的体重减轻，并在短期内维持。该提案的目标有两个：1）开展旨在改善该年龄段的招募和保留工作的形成性工作，2）进行随机临床试验，以测试三种不同长期方法的可行性和初步功效体重控制。在第一阶段，80 名 18-25 岁的超重或肥胖男性和女性将参加焦点小组，以解决招募、保留和治疗障碍的问题。在第二阶段，90 名参与者的新样本将参加为期 10 周的简短 BWL 计划，然后在 12 个月内随机分配到三个维持组之一。联系时间表和交付格式将部分由第一阶段确定；三支队伍将继续面对面、时事通讯控制或其他形式的持续接触。评估将在基线、10 周、6 和 12 个月时进行。 公共卫生相关性：肥胖在美国已达到流行病的程度，18 至 25 岁的年轻人面临的风险尤其高；迄今为止，标准的行为减肥计划尚未成功惠及这一高风险群体。目前尚不清楚如何最好地招募这些人进行最初的治疗，或者如何让他们长期接受治疗。拟议的研究填补了这一空白，因此具有重大的临床和公共卫生影响。