Exploring the Neural Circuitry of Deliberate Self Harm in Adolescents

探索青少年故意自残的神经回路

基本信息

批准号：
8301467
负责人：
Kathryn Regan Cullen
金额：
$ 22.8万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-19 至 2014-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8301467
关键词：
Adjustment Disorders Adolescence Adolescent Age Amygdaloid structure Anterior Anxiety Disorders Behavior Biological Neural Networks Borderline Personality Disorder Brain Brain imaging Brain region Clinical Conscious Control Groups Development Diagnosis Diagnostic Diffusion Magnetic Resonance Imaging Dimensions Disease Early treatment Eating Disorders Emotions Female Adolescents Foundations Fright Functional Magnetic Resonance Imaging Functional disorder Future Goals Laboratories Light Link Longitudinal Studies Major Depressive Disorder Maps Measures Mediating Mental disorders Methods Modeling Neurobiology Neuronal Plasticity Outcome Pain Pattern Pharmaceutical Preparations Pilot Projects Population Prevalence Process Psychiatry Psychopathology Public Health Recording of previous events Research Rest Risk Self-Injurious Behavior Severities Subconscious Substance abuse problem Suicide Suicide attempt Symptoms System Thalamic structure Time United States National Institutes of Health aged base brain behavior cingulate cortex emotion regulation girls improved meetings neural circuit neurobiological mechanism neurodevelopment non-suicidal self injury prevent psychologic relating to nervous system reward processing scaffold self esteem stem tool treatment response treatment strategy young woman

项目摘要

DESCRIPTION (provided by applicant): The goal of this brain imaging study is to examine brain connectivity in adolescent girls with non-suicidal self- injury (NSSI). To date, little is knwn about the neurobiological underpinnings of NSSI. This behavior occurs in a wide range of conditions including major depressive disorder (MDD), borderline personality disorder (BPD), anxiety disorders, substance abuse disorders, adjustment disorders and eating disorders. Conversely, many adolescents with NSSI do not meet criteria for any psychiatric disorders. Thus, the field has begun to consider NSSI not as a symptom of a specific disorder, but as an entity in its own right. Our laboratory has been developing methods to examine the connections within brain networks (connectivity) using diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). These tools allow for the application of systems-based approaches to examining the neural underpinnings of psychopathology, a recent priority in the field. Thus, instead of examining specific brain regions, recent research has been focused on characterizing connectivity within neural circuitry. Examination of brain connectivity is particularly relevant to studying problems that emerge in adolescence given the ongoing maturation of connections within relevant brain systems during this time period. The hypothesis of the current study is that aberrant neural circuitry underlies the tendency to engage in NSSI in adolescents. As we examine brain connectivity in this group, we will explore key psychological dimensions such as emotion regulation (and others) that could mediate the link between circuitry abnormalities and NSSI. In keeping with the NIH initiative RDoC, we focus not on diagnosis but on a specific behavior (i.e., NSSI); to increase homogeneity of the NSSI group we will include several constraints: medication-naive, girls only, a narrow range of age and pubertal development, and no history of SA. This project may represent the first study to examine neural circuitry of NSSI in adolescents, and thus will be a major step forward in uncovering neurobiological mechanisms that underlie NSSI. Elucidating the neural correlates of NSSI is especially important during adolescence; early intervention during a time of increased neuroplasticity could prevent entrenchment of aberrant behavior and promote healthy neurodevelopment. This project will provide the foundation for future longitudinal studies that will examine (a) predictors for course of psychopathology and treatment response, and (2) the impact of treatment on aberrant connectivity patterns in adolescents with NSSI (i.e., mechanisms of successful treatment.) PUBLIC HEALTH RELEVANCE: Deliberate self harm (DSH) occurs frequently in adolescents and poses considerable public health risks. Development of improved identification and treatment strategies depends on improving current understanding of underlying disease mechanisms. Results from the proposed study will yield new information to shed light on the pathophysiology of DSH in adolescence. These results will provide important guidance for future research investigating the impact of treatment on abnormal mechanisms in adolescents with DSH.

描述（由申请人提供）：这项大脑成像研究的目的是检查非自杀自损伤（NSSI）的青少年女孩的大脑连通性。迄今为止，关于NSSI的神经生物学基础的知识很少。这种行为发生在各种疾病中，包括重度抑郁症（MDD），边缘性人格障碍（BPD），焦虑症，药物滥用障碍，调整障碍和饮食失调。相反，许多具有NSSI的青少年不符合任何精神疾病的标准。因此，该领域已开始将NSSI视为特定疾病的症状，而是本身就是一个实体。我们的实验室一直在开发使用扩散张量成像（DTI）和功能磁共振成像（fMRI）检查大脑网络（连通性）（连通性）的方法。这些工具允许应用基于系统的方法来检查心理病理学的神经基础，这是该领域的最新优先级。因此，最近的研究没有检查特定的大脑区域，而是专注于表征神经回路内的连通性。检查大脑连接性与鉴于在此期间相关的大脑系统内的连接持续成熟，研究的问题会在青春期出现。当前研究的假设是，异常的神经回路是在青少年参与NSSI的趋势。当我们检查该组中的大脑连接性时，我们将探索关键的心理维度，例如情绪调节（和其他），这些维度可以介导电路异常与NSSI之间的联系。为了与NIH倡议RDOC保持一致，我们不专注于诊断，而是针对特定行为（即NSSI）。为了增加NSSI集团的同质性，我们将包括一些限制：药物，只有女孩，年龄范围狭窄，没有SA的历史。该项目可能代表了第一个研究NSSI神经回路的研究青少年，因此将是揭示NSSI构成的神经生物学机制的重要一步。阐明NSSI的神经相关性在青春期尤为重要。在增加神经可塑性时期的早期干预可以防止异常行为的根深蒂固并促进健康的神经发育。该项目将为未来的纵向研究奠定基础，该研究将检查（a）心理病理学和治疗反应过程的预测因素，以及（2）治疗对NSSI青少年（即成功治疗机制）的异常连通性模式的影响。公共卫生相关性：故意自我伤害（DSH）经常发生在青少年中，并带来很大的公共卫生风险。改进的鉴定和治疗策略的发展取决于提高对潜在疾病机制的当前理解。拟议的研究的结果将产生新的信息，以阐明青春期DSH的病理生理。这些结果将为未来的研究提供重要的指导，以研究治疗对DSH青少年异常机制的影响。