COBRE III: Center for Cardiovascular Research

COBRE III：心血管研究中心

基本信息

批准号：
8550107
负责人：
Ralph V. Shohet
金额：
$ 105.76万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-24 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8550107
关键词：
Address Affect Award Basic Science Biomedical Research Burn injury Cardiovascular system Centers of Research Excellence Core Facility Disease Educational process of instructing Ethnic group Extramural Activities Faculty Foundations Functional disorder Funding Genomics Goals Grant Growth Hawaii Hawaiian population Heart Diseases Histology Histopathology Institution Investigation Investments Knowledge Laboratories Medical Mentors Molecular Mus Philanthropic Fund Physiology Pilot Projects Population Population Heterogeneity Recruitment Activity Research Research Infrastructure Research Personnel Resources Schools Science Secure Services Solid Students Techniques Training Training Support Underrepresented Minority Underserved Population United States National Institutes of Health Universities Work base health disparity medical schools new technology next generation programs public health relevance response success

项目摘要

DESCRIPTION (provided by applicant): We are submitting this renewal application for the Cardiovascular Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health PAR-10-196. The John A. Burns School of Medicine has established a Center for Cardiovascular Research (OCR), led by Dr. Ralph Shohet, an R01-funded molecular cardiologist. During the NCRR's investment in our Center through two previous cycles of funding, our junior investigators have successfully competed for 6 new R01s and 3 R21s, in addition to NSF, AHA, and local philanthropic funding. During the past five years we recruited two senior faculty and 3 junior faculty to our program using a combination of institutional and COBRE support. We have also established three Core laboratories that provide crucial services for modern biomedical science, in Genomics, Histopathology, and Mouse Physiology. These accomplishments fulfill the initial goals of the Cardiovascular COBRE program to strengthen the biomedical research capacity of the Medical School and the University and enhance the ability of our investigators to compete for independent extramural funding. We plan to build upon the success of the first two COBRE cycles by enhancing these core facilities and placing them on a secure and sustainable financial basis, so that they can continue to support biomedical research at our institution. Our long-term goal is to continue to train and support the cadre of skilled researchers whose studies will ultimately reduce heart disease and eliminate cardiovascular health disparities among the diverse ethnic groups of Hawaii, particularly Native Hawaiians. Our two specific aims are: 1. to maintain the growth and enhance the sustainability of Core services, and 2. to develop a pilot project program that will fund the best ideas of our investigators to the point where they are competitive for extramural support.

描述（由申请人提供）：我们正在向夏威夷大学 (UH) 心血管生物医学卓越研究中心 (COBRE) 提交续期申请，以回应美国国立卫生研究院 PAR-10-196。约翰·A·伯恩斯医学院建立了心血管研究中心 (OCR)，由 R01 资助的分子心脏病学家 Ralph Shohet 博士领导。在 NCRR 通过前两个资助周期对我们中心进行投资期间，除了 NSF、AHA 和当地慈善基金外，我们的初级研究人员还成功竞争了 6 个新的 R01 和 3 个 R21。在过去五年中，我们结合机构和 COBRE 支持招募了 2 名高级教师和 3 名初级教师加入我们的项目。我们还建立了基因组学、组织病理学和小鼠生理学三个核心实验室，为现代生物医学科学提供重要服务。这些成就实现了心血管 COBRE 计划的最初目标，即加强医学院和大学的生物医学研究能力，并提高我们的研究人员竞争独立外部资金的能力。我们计划在前两个 COBRE 周期成功的基础上，加强这些核心设施并将其置于安全和可持续的财务基础上，以便它们能够继续支持我们机构的生物医学研究。我们的长期目标是继续培训和支持熟练的研究人员队伍，他们的研究最终将减少心脏病并消除夏威夷不同种族群体（特别是夏威夷原住民）之间的心血管健康差异。我们的两个具体目标是：1. 保持核心服务的增长并增强其可持续性；2. 制定试点项目计划，为我们研究人员的最佳想法提供资助，使他们在外部支持方面具有竞争力。