COBRE III: Center for Cardiovascular Research

COBRE III：心血管研究中心

基本信息

批准号：
8305804
负责人：
Ralph V. Shohet
金额：
$ 91.63万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-24 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8305804
关键词：
Address Affect Award Basic Science Biomedical Research Burn injury Cardiovascular system Centers of Research Excellence Core Facility Disease Educational process of instructing Ethnic group Extramural Activities Faculty Foundations Functional disorder Funding Genomics Goals Grant Growth Hawaii Hawaiian population Heart Diseases Histology Histopathology Institution Investigation Investments Knowledge Laboratories Medical Mentors Molecular Mus Philanthropic Fund Physiology Pilot Projects Population Population Heterogeneity Recruitment Activity Research Research Infrastructure Research Personnel Resources Schools Science Secure Services Solid Students Techniques Training Training Support Underrepresented Minority Underserved Population United States National Institutes of Health Universities Work base health disparity medical schools new technology next generation programs response success

项目摘要

DESCRIPTION (provided by applicant): We are submitting this renewal application for the Cardiovascular Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health PAR-10-196. The John A. Burns School of Medicine has established a Center for Cardiovascular Research (OCR), led by Dr. Ralph Shohet, an R01-funded molecular cardiologist. During the NCRR's investment in our Center through two previous cycles of funding, our junior investigators have successfully competed for 6 new R01s and 3 R21s, in addition to NSF, AHA, and local philanthropic funding. During the past five years we recruited two senior faculty and 3 junior faculty to our program using a combination of institutional and COBRE support. We have also established three Core laboratories that provide crucial services for modern biomedical science, in Genomics, Histopathology, and Mouse Physiology. These accomplishments fulfill the initial goals of the Cardiovascular COBRE program to strengthen the biomedical research capacity of the Medical School and the University and enhance the ability of our investigators to compete for independent extramural funding. We plan to build upon the success of the first two COBRE cycles by enhancing these core facilities and placing them on a secure and sustainable financial basis, so that they can continue to support biomedical research at our institution. Our long-term goal is to continue to train and support the cadre of skilled researchers whose studies will ultimately reduce heart disease and eliminate cardiovascular health disparities among the diverse ethnic groups of Hawaii, particularly Native Hawaiians. Our two specific aims are: 1. to maintain the growth and enhance the sustainability of Core services, and 2. to develop a pilot project program that will fund the best ideas of our investigators to the point where they are competitive for extramural support. PUBLIC HEALTH RELEVANCE (provided by applicant): With a new campus, new faculty, and renascent administration, our Medical School has embarked on a new direction, developing into a research-centric school that will address the medical problems of our population at a basic level, and provide a new bioscience component to our economy. These Cores provide the capabilities required for modern biomedical science and in some cases are the only such resources in the State.

描述（由申请人提供）：我们正在为夏威夷大学（UH）的生物医学研究卓越中心（COBRE）提交此续签申请，以回应国家卫生研究院10-196。约翰·伯恩斯（John A. Burns）医学院已建立了由R01资助的分子心脏病专家Ralph Shohet博士领导的心血管研究中心（OCR）。在NCRR通过之前的两个资金周期对我们中心的投资期间，我们的初级调查人员除了NSF，AHA和当地的慈善资金外，已经成功竞争了6个新的R01和3 R21。在过去的五年中，我们使用机构和鞋底支持的组合招募了两名高级教师和3名初级教职员工。我们还建立了三个核心实验室，这些实验室为现代生物医学科学，基因组学，组织病理学和小鼠生理学提供重要服务。这些成就实现了心血管鞋底计划的最初目标，以增强医学院和大学的生物医学研究能力，并增强我们调查人员争夺独立壁外资金的能力。我们计划通过加强这些核心设施并将其置于安全可持续的财务基础上，以前两个毛绒周期的成功为基础，以便他们可以继续支持我们机构的生物医学研究。我们的长期目标是继续培训和支持熟练研究人员的干部，他们的研究最终将减少心脏病并消除夏威夷不同种族的心血管健康差异，尤其是夏威夷原住民。我们的两个具体目的是：1。维持增长并增强核心服务的可持续性，以及2。制定试点项目计划，该计划将为调查人员提供最佳想法，以便他们在校外支持方面具有竞争力。公共卫生相关性（由申请人提供）：通过新的校园，新的教职员工和重生的管理，我们的医学院踏上了新的方向，发展成为以研究为中心的学校，该学校将在基本水平上解决我们人口的医疗问题，并为我们的经济提供新的生物科学组成部分。这些核心提供了现代生物医学科学所需的功能，在某些情况下是该州唯一的资源。