Genetic and physiological mechanisms of temperature detection and compensation

温度检测和补偿的遗传和生理机制

• 批准号: 8416054
• 负责人: Piali Sengupta
• 金额: $ 130.83万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416054
• 关键词: Address; Animals; Area; Behavior; Behavioral; Biochemical Reaction; Blood; Carbon Dioxide; Complex; Cues; Detection; Environment; Esthesia; Febrile Convulsions; Financial compensation; Genetic; Goals; Investigation; Life; Literature; Medical; Molecular; Motor; Multiple Sclerosis; Nervous System Physiology; Nervous system structure; Neurons; Output; Pain; Pharmaceutical Preparations; Physiological; Physiological Adaptation; Program Research Project Grants; Recording of previous events; Research; Research Personnel; Stimulus; Syndrome; System; Temperature; Translating; Variant; base; coping; design; experience; fascinate; induced hypothermia; new technology; programs; public health relevance; response; sensor

DESCRIPTION (provided by applicant): All animals live in constantly changing environments and are, therefore, subjected to fluctuations in critical environmental cues such as temperature. Given that all biochemical reactions are temperature sensitive to a certain extent, it is particularly critical for animals to compensate for these temperature changes in order to maintain steady internal conditions. In order to do so, animals must be able to detect small temperature changes and then trigger the appropriate homeostatic compensatory mechanisms. To date, research into the molecular and neuronal basis of temperature detection and thermotransduction, and the physiological mechanisms of temperature adaptation and compensation, have largely been pursued as independent lines of investigation. To obtain a full understanding of how animals respond appropriately to temperature changes, these intellectual issues must be brought together and studied as a whole. In this Program Project grant we bring together researchers experienced in issues of temperature detection and temperature compensation to ask how animals detect temperature changes and translate this information to effect compensatory changes in neuron function to maintain behavioral robustness. A particular strength of this proposal is the synergy among investigators exploring these issues in multiple systems; this diversity will elucidate common underlying principles that can be generalized ID other species. The overall questions being asked here are: 1) What are the molecular mechanisms by which animals detect temperature changes? 2) What are the neuronal mechanisms that encode information about temperature changes? 3) How do motor programs compensate for temperature fluctuations? 4) What defines the limits of the range in which these homeostatic mechanisms operate? 5) What are the common principles of temperature detection and compensation among species?

描述（由申请人提供）：所有动物都生活在不断变化的环境中，因此在诸如温度的关键环境线索中受到波动。鉴于所有生化反应在一定程度上敏感的温度均敏感，因此为动物补偿这些温度变化以维持稳定的内部条件特别重要。为此，动物必须能够检测到较小的温度变化，然后触发适当的稳态补偿机制。迄今为止，对温度检测和热转导的分子和神经元基础的研究以及温度适应和补偿的生理机制已被主要作为独立的研究行为。为了充分了解动物如何对温度变化做出适当的反应，必须将这些智力问题汇集在一起​​并整体研究。在这个计划项目赠款中，我们将研究人员汇集在一起​​，在温度检测和温度补偿问题中经历了经验丰富的研究人员，以询问动物如何检测温度变化并转化此信息以实现神经元功能的补偿性变化，以维持行为鲁棒性。该提案的一个特殊优势是调查人员之间在多个系统中探索这些问题的协同作用。这种多样性将阐明可以概括其他物种的常见基本原则。这里问的总体问题是： 1）哪些动物检测到温度变化的分子机制是什么？ 2）编码有关温度变化的信息的神经元机制是什么？ 3）运动计划如何补偿温度波动？ 4）是什么定义了这些稳态机制运行的范围的限制？ 5）物种之间温度检测和补偿的共同原则是什么？