Simple Automatic Perfusion System for salvage after cardiac arrest

用于心脏骤停后抢救的简单自动灌注系统

基本信息

批准号：
8213652
负责人：
DANIEL Edward MAZUR
金额：
$ 55.36万
依托单位：
MC3, INC.
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-02-01 至 2014-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8213652
关键词：
Age Animal Experiments Animal Model Animal Testing Animals Anticoagulation Attention Blood Blood Vessels Blood flow Blood gas Brain Brain Death Cardiac Death Cardiopulmonary Resuscitation Cattle Cessation of life Characteristics Clinical Research Devices Dimensions Documentation Engineering Evaluation Failure Family suidae Force of Gravity Freezing Gases Glycerol Goals Heart Heart Arrest Hemolysis Hour In Vitro Institute of Medicine (U.S.)Intervention Laboratories Life Mechanics Metabolic Methods Michigan Modeling Organ Organ Donor Organ Transplantation Oxygen Oxygenators Paramedical Personnel Performance Perfusion Phase Positioning Attribute Protocols documentation Pump Renal function Reporting Research Research Project Grants Respiratory physiology Resuscitation Risk Risk Management Running Safety Sampling Solutions Speed System Technology Temperature Testing Transplantation Universities Venous Water Weight analog base blood perfusion design femoral artery improved in vitro testing indexing innovation liver function meetings portability pressure prototype research study response success

项目摘要

DESCRIPTION (provided by applicant): Extracorporeal support (ECPR) improves survival in resuscitation from cardiac arrest from 5% to 30%. Extracorporeal support facilitates the salvage of donor organs after cardiac death (DCD). The Institute of Medicine report states that innovative methods to salvage DCD organs are the highest priority in organ transplantation. However ECS is rarely used for these applications. The limiting factor is the need for a simple automatic perfusion system which is inherently safe, can be initiated by paramedical personnel, and provides full support without operator intervention. MC3 is uniquely positioned to develop such a device. The research team at the University of Michigan has demonstrated that ECPR is feasible and results in 30% healthy survival. The same team has shown that mechanical organ perfusion after death by cardiac arrest (DCD-ECS) restores liver and kidney function to transplantable status. Moreover, after transplantation these DCD-ECS organs are even more successful than organs from heart-beating brain dead donors. The goal of this research project is to design and produce a simple Automatic Perfusion System (APS) for extracorporeal support to facilitate ECPR and organ salvage from donors after cardiac arrest.

描述（由申请人提供）：体外支持 (ECPR) 将心脏骤停复苏的存活率从 5% 提高到 30%。体外支持有助于心源性死亡 (DCD) 后捐献器官的抢救。医学研究所的报告指出，抢救DCD器官的创新方法是器官移植的重中之重。然而，ECS 很少用于这些应用程序。限制因素是需要一个简单的自动灌注系统，该系统本质上是安全的，可以由护理人员启动，并且无需操作员干预即可提供全面支持。 MC3 具有独特的优势来开发此类设备。密歇根大学的研究团队已经证明 ECPR 是可行的，并且可以实现 30% 的健康存活率。该团队还表明，心脏骤停死亡后机械器官灌注（DCD-ECS）可将肝肾功能恢复至可移植状态。此外，移植后这些 DCD-ECS 器官甚至比心跳脑死亡捐献者的器官更成功。该研究项目的目标是设计和生产一种简单的自动灌注系统（APS），用于体外支持，以促进心脏骤停后心肺复苏和捐献者的器官抢救。