2011 Biological Molecules in the Gas Phase and in Solution GRC

2011 气相和溶液中的生物分子 GRC

基本信息

批准号：
8193187
负责人：
DAVID E. CLEMMER
金额：
$ 0.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-15 至 2012-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Support is requested for the Gordon Research Conference on "Biological Molecules in the Gas Phase and in Solution", which will take place during the week of July 31 to August 5, 2011 at Proctor Academy, Andover, New Hampshire. This Gordon Research Conference (GRC) will provide an international forum for discussing fundamental questions related to the structure and dynamics of proteins, peptides, nucleic acids, carbohydrates, and other molecular building blocks of life. One focus of this meeting is the characterization of biological molecules by mass spectrometry and related approaches (including chemical labeling, ion mobility and various dissociation methods). Another emphasis is on the interrogation of biomolecular systems by spectroscopic tools. In addition, the conference will highlight key computational and theoretical contributions. Some of the issues that will be addressed include the following: How do biological molecules behave once they have been deprived of their aqueous environment? How can gas phase methods be employed for obtaining structural information on biological molecules in solution? How do biological molecules interact with water? How do biological molecules behave in solvents other than water? The uniqueness of this meeting stems from its strongly interdisciplinary character, as it brings together experimentalists and theorists working at the interface of chemistry, biology, physics, and medicine. This GRC also provides a perfect opportunity for young scientists to interact with established and emerging leaders in all of these areas. The conference chairs have assembled a cutting-edge program that includes 36 leading scientists, all of whom have confirmed their attendance. In addition to invited oral presentations there will be several poster sessions. The conference program is available on-line at http://www.grc.org/programs.aspx?year=2011&program=gasphase). PUBLIC HEALTH RELEVANCE: New developments in medicine and public health in the 21st Century are likely to depend on an improved understanding of the structure, dynamics, and function of biological systems at the molecular level. The Gordon Research Conference on Biological Molecules in the Gas Phase and in Solution was created in 2001 to address this need. The 2011 meeting, the sixth in the series, will especially focus on identifying the frontier areas in biology that will benefit from collaborative research involving the biomolecular mass spectrometry, optical spectroscopy, and computational chemistry modeling communities.

说明（由申请人提供）：请求支持戈登研究会议“气相和溶液中的生物分子”，该会议将于 2011 年 7 月 31 日至 8 月 5 日这一周在新州安多佛普罗克特学院举行汉普郡。本次戈登研究会议 (GRC) 将提供一个国际论坛，讨论与蛋白质、肽、核酸、碳水化合物和其他生命分子构建模块的结构和动力学相关的基本问题。本次会议的焦点之一是通过质谱和相关方法（包括化学标记、离子淌度和各种解离方法）表征生物分子。另一个重点是通过光谱工具询问生物分子系统。此外，会议还将强调关键的计算和理论贡献。将解决的一些问题包括：生物分子一旦脱离水环境，它们将如何表现？如何采用气相方法获取溶液中生物分子的结构信息？生物分子如何与水相互作用？生物分子在水以外的溶剂中如何表现？这次会议的独特性源于其强烈的跨学科特征，因为它汇集了化学、生物学、物理学和医学交叉领域的实验学家和理论家。该 GRC 还为年轻科学家提供了与所有这些领域的知名和新兴领导者互动的绝佳机会。会议主席们制定了一项前沿计划，其中包括 36 名顶尖科学家，他们均已确认出席。除了受邀的口头报告外，还将举行几次海报会议。会议日程可在线获取：http://www.grc.org/programs.aspx?year=2011&program=gasphase)。公共卫生相关性：21 世纪医学和公共卫生的新发展可能取决于在分子水平上对生物系统的结构、动力学和功能的更好理解。戈登气相和溶液生物分子研究会议于 2001 年成立，旨在满足这一需求。 2011 年会议是该系列的第六次会议，将特别关注确定生物学前沿领域，这些领域将受益于涉及生物分子质谱、光谱和计算化学建模社区的合作研究。